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Deterioration of trabecular plate-rod and cortical microarchitecture and reduced bone stiffness at distal radius and tibia in postmenopausal women with vertebral fractures.
Bone. 2016 07; 88:39-46.BONE

Abstract

Postmenopausal women with vertebral fractures have abnormal bone microarchitecture at the distal radius and tibia by HR-pQCT, independent of areal BMD. However, whether trabecular plate and rod microarchitecture is altered in women with vertebral fractures is unknown. This study aims to characterize the abnormalities of trabecular plate and rod microarchitecture, cortex, and bone stiffness in postmenopausal women with vertebral fractures. HR-pQCT images of distal radius and tibia were acquired from 45 women with vertebral fractures and 45 control subjects without fractures. Trabecular and cortical compartments were separated by an automatic segmentation algorithm and subjected to individual trabecula segmentation (ITS) analysis for measuring trabecular plate and rod morphology and cortical bone evaluation for measuring cortical thickness and porosity, respectively. Whole bone and trabecular bone stiffness were estimated by finite element analysis. Fracture and control subjects did not differ according to age, race, body mass index, osteoporosis risk factors, or medication use. Women with vertebral fractures had thinner cortices, and larger trabecular area compared to the control group. By ITS analysis, fracture subjects had fewer trabecular plates, less axially aligned trabeculae and less trabecular connectivity at both the radius and the tibia. Fewer trabecular rods were observed at the radius. Whole bone stiffness and trabecular bone stiffness were 18% and 22% lower in women with vertebral fractures at the radius, and 19% and 16% lower at the tibia, compared with controls. The estimated failure load of the radius and tibia were also reduced in the fracture subjects by 13% and 14%, respectively. In summary, postmenopausal women with vertebral fractures had both trabecular and cortical microstructural deterioration at the peripheral skeleton, with a preferential loss of trabecular plates and cortical thinning. These microstructural deficits translated into lower whole bone and trabecular bone stiffness at the radius and tibia. Our results suggest that abnormalities in trabecular plate and rod microstructure may be important mechanisms of vertebral fracture in postmenopausal women.

Authors+Show Affiliations

Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: jw2857@columbia.edu.Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: es2029@cumc.columbia.edu.Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: bz2159@columbia.edu.Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: kn2205@cumc.columbia.edu.Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: yy2407@columbia.edu.Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: es54@cumc.columbia.edu.Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: exg1@columbia.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27083398

Citation

Wang, Ji, et al. "Deterioration of Trabecular Plate-rod and Cortical Microarchitecture and Reduced Bone Stiffness at Distal Radius and Tibia in Postmenopausal Women With Vertebral Fractures." Bone, vol. 88, 2016, pp. 39-46.
Wang J, Stein EM, Zhou B, et al. Deterioration of trabecular plate-rod and cortical microarchitecture and reduced bone stiffness at distal radius and tibia in postmenopausal women with vertebral fractures. Bone. 2016;88:39-46.
Wang, J., Stein, E. M., Zhou, B., Nishiyama, K. K., Yu, Y. E., Shane, E., & Guo, X. E. (2016). Deterioration of trabecular plate-rod and cortical microarchitecture and reduced bone stiffness at distal radius and tibia in postmenopausal women with vertebral fractures. Bone, 88, 39-46. https://doi.org/10.1016/j.bone.2016.04.003
Wang J, et al. Deterioration of Trabecular Plate-rod and Cortical Microarchitecture and Reduced Bone Stiffness at Distal Radius and Tibia in Postmenopausal Women With Vertebral Fractures. Bone. 2016;88:39-46. PubMed PMID: 27083398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deterioration of trabecular plate-rod and cortical microarchitecture and reduced bone stiffness at distal radius and tibia in postmenopausal women with vertebral fractures. AU - Wang,Ji, AU - Stein,Emily M, AU - Zhou,Bin, AU - Nishiyama,Kyle K, AU - Yu,Y Eric, AU - Shane,Elizabeth, AU - Guo,X Edward, Y1 - 2016/04/12/ PY - 2015/09/14/received PY - 2016/03/07/revised PY - 2016/04/04/accepted PY - 2016/4/17/entrez PY - 2016/4/17/pubmed PY - 2017/12/19/medline KW - Bone microarchitecture KW - High-resolution peripheral quantitative computed tomography KW - Individual trabecula segmentation KW - Trabecular plate and rod KW - Vertebral fracture SP - 39 EP - 46 JF - Bone JO - Bone VL - 88 N2 - Postmenopausal women with vertebral fractures have abnormal bone microarchitecture at the distal radius and tibia by HR-pQCT, independent of areal BMD. However, whether trabecular plate and rod microarchitecture is altered in women with vertebral fractures is unknown. This study aims to characterize the abnormalities of trabecular plate and rod microarchitecture, cortex, and bone stiffness in postmenopausal women with vertebral fractures. HR-pQCT images of distal radius and tibia were acquired from 45 women with vertebral fractures and 45 control subjects without fractures. Trabecular and cortical compartments were separated by an automatic segmentation algorithm and subjected to individual trabecula segmentation (ITS) analysis for measuring trabecular plate and rod morphology and cortical bone evaluation for measuring cortical thickness and porosity, respectively. Whole bone and trabecular bone stiffness were estimated by finite element analysis. Fracture and control subjects did not differ according to age, race, body mass index, osteoporosis risk factors, or medication use. Women with vertebral fractures had thinner cortices, and larger trabecular area compared to the control group. By ITS analysis, fracture subjects had fewer trabecular plates, less axially aligned trabeculae and less trabecular connectivity at both the radius and the tibia. Fewer trabecular rods were observed at the radius. Whole bone stiffness and trabecular bone stiffness were 18% and 22% lower in women with vertebral fractures at the radius, and 19% and 16% lower at the tibia, compared with controls. The estimated failure load of the radius and tibia were also reduced in the fracture subjects by 13% and 14%, respectively. In summary, postmenopausal women with vertebral fractures had both trabecular and cortical microstructural deterioration at the peripheral skeleton, with a preferential loss of trabecular plates and cortical thinning. These microstructural deficits translated into lower whole bone and trabecular bone stiffness at the radius and tibia. Our results suggest that abnormalities in trabecular plate and rod microstructure may be important mechanisms of vertebral fracture in postmenopausal women. SN - 1873-2763 UR - https://www.unboundmedicine.com/medline/citation/27083398/Deterioration_of_trabecular_plate_rod_and_cortical_microarchitecture_and_reduced_bone_stiffness_at_distal_radius_and_tibia_in_postmenopausal_women_with_vertebral_fractures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(16)30089-8 DB - PRIME DP - Unbound Medicine ER -