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Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study.
Graefes Arch Clin Exp Ophthalmol. 2016 Sep; 254(9):1841-9.GA

Abstract

PURPOSE

To describe the clinical and visual outcomes of juvenile idiopathic arthritis (JIA)-associated uveitis in adults and to examine risk factors for ongoing inflammation in adulthood.

METHODS

Medical records were reviewed for patients with JIA-associated uveitis who were >16 years old at the final visit (the last visit prior to data collection).

RESULTS

In total, 135 eyes of 77 patients (70 female, 7 male) were included. The mean age of patients at the final visit was 29.72 ± 11.27 years. The number of eyes with visual acuity of ≤20/50 and ≤20/200 at the final visit was 37 (28 %) and 20 (15 %), respectively; at least one ocular complication was present in 72 % of eyes. Band keratopathy was the most frequent complication (42 %), followed by cataract (25 %), posterior synechiae (22 %), maculopathy (22 %), ocular hypertension (13 %), and hypotony (5 %). At the final visit, patients who were >16 years of age at presentation to the Massachusetts Eye Research and Surgery Institution had more ocular complications and a greater degree of vision loss than patients who were ≤16 years of age. Ongoing inflammation at the final visit was noted in 40 patients (52 %). The presence of posterior synechiae, hypotony, cataract at presentation, and a history of cataract surgery prior to presentation were predictive of ongoing inflammation in adulthood in univariate analysis. The presence of hypotony and posterior synechiae at the initial visit were predictive factors in multivariate analysis.

CONCLUSIONS

JIA-associated uveitis may be associated with ongoing inflammation, ocular complications, and severe visual impairment in adulthood. The presence of posterior synechiae and hypotony at the initial visit is predictive of ongoing inflammation.

Authors+Show Affiliations

Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA. Ocular Immunology and Uveitis Foundation, Waltham, MA, USA. Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Istanbul, Turkey.Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA. Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA. Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA. Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA. fosters@uveitis.org. Ocular Immunology and Uveitis Foundation, Waltham, MA, USA. fosters@uveitis.org. Harvard Medical School, Boston, MA, USA. fosters@uveitis.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27084082

Citation

Oray, Merih, et al. "Ocular Morbidities of Juvenile Idiopathic Arthritis-associated Uveitis in Adulthood: Results From a Tertiary Center Study." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 254, no. 9, 2016, pp. 1841-9.
Oray M, Khachatryan N, Ebrahimiadib N, et al. Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study. Graefes Arch Clin Exp Ophthalmol. 2016;254(9):1841-9.
Oray, M., Khachatryan, N., Ebrahimiadib, N., Abu Samra, K., Lee, S., & Foster, C. S. (2016). Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 254(9), 1841-9. https://doi.org/10.1007/s00417-016-3340-z
Oray M, et al. Ocular Morbidities of Juvenile Idiopathic Arthritis-associated Uveitis in Adulthood: Results From a Tertiary Center Study. Graefes Arch Clin Exp Ophthalmol. 2016;254(9):1841-9. PubMed PMID: 27084082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study. AU - Oray,Merih, AU - Khachatryan,Naira, AU - Ebrahimiadib,Nazanin, AU - Abu Samra,Khawla, AU - Lee,Stacey, AU - Foster,C Stephen, Y1 - 2016/04/15/ PY - 2016/02/09/received PY - 2016/03/31/accepted PY - 2016/03/24/revised PY - 2016/4/17/entrez PY - 2016/4/17/pubmed PY - 2017/3/30/medline KW - Anterior uveitis KW - Juvenile idiopathic arthritis KW - Ocular complications SP - 1841 EP - 9 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 254 IS - 9 N2 - PURPOSE: To describe the clinical and visual outcomes of juvenile idiopathic arthritis (JIA)-associated uveitis in adults and to examine risk factors for ongoing inflammation in adulthood. METHODS: Medical records were reviewed for patients with JIA-associated uveitis who were >16 years old at the final visit (the last visit prior to data collection). RESULTS: In total, 135 eyes of 77 patients (70 female, 7 male) were included. The mean age of patients at the final visit was 29.72 ± 11.27 years. The number of eyes with visual acuity of ≤20/50 and ≤20/200 at the final visit was 37 (28 %) and 20 (15 %), respectively; at least one ocular complication was present in 72 % of eyes. Band keratopathy was the most frequent complication (42 %), followed by cataract (25 %), posterior synechiae (22 %), maculopathy (22 %), ocular hypertension (13 %), and hypotony (5 %). At the final visit, patients who were >16 years of age at presentation to the Massachusetts Eye Research and Surgery Institution had more ocular complications and a greater degree of vision loss than patients who were ≤16 years of age. Ongoing inflammation at the final visit was noted in 40 patients (52 %). The presence of posterior synechiae, hypotony, cataract at presentation, and a history of cataract surgery prior to presentation were predictive of ongoing inflammation in adulthood in univariate analysis. The presence of hypotony and posterior synechiae at the initial visit were predictive factors in multivariate analysis. CONCLUSIONS: JIA-associated uveitis may be associated with ongoing inflammation, ocular complications, and severe visual impairment in adulthood. The presence of posterior synechiae and hypotony at the initial visit is predictive of ongoing inflammation. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/27084082/Ocular_morbidities_of_juvenile_idiopathic_arthritis_associated_uveitis_in_adulthood:_results_from_a_tertiary_center_study_ DB - PRIME DP - Unbound Medicine ER -