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Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents.
Int Arch Occup Environ Health 2016; 89(6):911-21IA

Abstract

PURPOSE

The study was conducted to explore the mechanisms linking traffic-related air pollution and cardio-metabolic risk.

METHODS

The participants included 371 men and women aged from 45 to 75 in an urban residential area in Shanghai, China. The participants were divided into four categories (≤50, 51-100, 101-200 and >200 m) according to the residential distance to major road. Additionally, the personal fine particulate matter (PM2.5) was measured from 8:00 am to 6:00 pm to assess the PM2.5 exposure in general residents. Then, the continuous subclinical measurements and biological effects related to cardio-metabolic disorders were detected. The generalized linear regression analysis was applied for estimating the adjusted hazards ratio for cardio-metabolic disorders relative to traffic-related air pollution.

RESULTS

The average personal PM2.5 is 111.1 μg/m(3) in the participants living within 50 m to major road, which is significantly higher than the personal PM2.5 (68.2 μg/m(3)) in the participants living more than 200 m away from the major road. The participants living within 50 m to major road compared with those living more than 200 m away have 1.15 times higher of heart rate (HR), 1.95 times higher of fasting insulin, 1.30 times higher of homeostasis model assessment of insulin resistance (HOMA-IR), 1.56 times higher of low-density lipoprotein cholesterol (LDL-C), 8.39 times higher of interleukin 6 (IL-6), 4.30 times higher of augmentation index (AI), 1.60 times higher of systolic blood pressure (SBP) and 1.91 times higher of diastolic blood pressure (DBP). Contrary to the increase in above biological effects, there were 1.06 times lower of low frequency (LF), 1.05 times lower of high frequency (HF), 2.54 times lower of IL-10, 4.61 times lower of nitric oxide (NO), 1.19 times lower of superoxide dismutase (SOD) and 1.85 times lower of total antioxidant capacity (T-AOC). There was no clear exposure-response relationship can be observed in the fasting glucose, LF/HF, cholesterol and high-density lipoprotein (HDL).

CONCLUSION

Long-term exposure to traffic-related air pollution may contribute to the development or exacerbation of cardio-metabolic disorders. The mechanisms linking air pollution and cardio-metabolic disorders may be associated with the increased systemic inflammation and oxidative stress, reduced insulin sensitivity and elevated arterial stiffness and blood pressure.

Authors+Show Affiliations

Department of Environmental Health, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, 331 Building 8, 130 Dong'an Road, Shanghai, 200032, China.Department of Environmental Health, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, 331 Building 8, 130 Dong'an Road, Shanghai, 200032, China.Department of Environmental Health, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, 331 Building 8, 130 Dong'an Road, Shanghai, 200032, China.Department of Environmental Health, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, 331 Building 8, 130 Dong'an Road, Shanghai, 200032, China.Department of Environmental Health, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, 331 Building 8, 130 Dong'an Road, Shanghai, 200032, China.Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Environmental Health, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, 331 Building 8, 130 Dong'an Road, Shanghai, 200032, China.Department of Environmental Health, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, 331 Building 8, 130 Dong'an Road, Shanghai, 200032, China. jinzhuozhao@fudan.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27084335

Citation

Jiang, Shuo, et al. "Traffic-related Air Pollution Is Associated With Cardio-metabolic Biomarkers in General Residents." International Archives of Occupational and Environmental Health, vol. 89, no. 6, 2016, pp. 911-21.
Jiang S, Bo L, Gong C, et al. Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents. Int Arch Occup Environ Health. 2016;89(6):911-21.
Jiang, S., Bo, L., Gong, C., Du, X., Kan, H., Xie, Y., ... Zhao, J. (2016). Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents. International Archives of Occupational and Environmental Health, 89(6), pp. 911-21. doi:10.1007/s00420-016-1129-3.
Jiang S, et al. Traffic-related Air Pollution Is Associated With Cardio-metabolic Biomarkers in General Residents. Int Arch Occup Environ Health. 2016;89(6):911-21. PubMed PMID: 27084335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents. AU - Jiang,Shuo, AU - Bo,Liang, AU - Gong,Changyi, AU - Du,Xihao, AU - Kan,Haidong, AU - Xie,Yuquan, AU - Song,Weimin, AU - Zhao,Jinzhuo, Y1 - 2016/04/15/ PY - 2016/01/05/received PY - 2016/04/07/accepted PY - 2016/4/17/entrez PY - 2016/4/17/pubmed PY - 2017/7/15/medline KW - Cardio-metabolic disorders KW - Fine particulate matter KW - Traffic-related air pollution SP - 911 EP - 21 JF - International archives of occupational and environmental health JO - Int Arch Occup Environ Health VL - 89 IS - 6 N2 - PURPOSE: The study was conducted to explore the mechanisms linking traffic-related air pollution and cardio-metabolic risk. METHODS: The participants included 371 men and women aged from 45 to 75 in an urban residential area in Shanghai, China. The participants were divided into four categories (≤50, 51-100, 101-200 and >200 m) according to the residential distance to major road. Additionally, the personal fine particulate matter (PM2.5) was measured from 8:00 am to 6:00 pm to assess the PM2.5 exposure in general residents. Then, the continuous subclinical measurements and biological effects related to cardio-metabolic disorders were detected. The generalized linear regression analysis was applied for estimating the adjusted hazards ratio for cardio-metabolic disorders relative to traffic-related air pollution. RESULTS: The average personal PM2.5 is 111.1 μg/m(3) in the participants living within 50 m to major road, which is significantly higher than the personal PM2.5 (68.2 μg/m(3)) in the participants living more than 200 m away from the major road. The participants living within 50 m to major road compared with those living more than 200 m away have 1.15 times higher of heart rate (HR), 1.95 times higher of fasting insulin, 1.30 times higher of homeostasis model assessment of insulin resistance (HOMA-IR), 1.56 times higher of low-density lipoprotein cholesterol (LDL-C), 8.39 times higher of interleukin 6 (IL-6), 4.30 times higher of augmentation index (AI), 1.60 times higher of systolic blood pressure (SBP) and 1.91 times higher of diastolic blood pressure (DBP). Contrary to the increase in above biological effects, there were 1.06 times lower of low frequency (LF), 1.05 times lower of high frequency (HF), 2.54 times lower of IL-10, 4.61 times lower of nitric oxide (NO), 1.19 times lower of superoxide dismutase (SOD) and 1.85 times lower of total antioxidant capacity (T-AOC). There was no clear exposure-response relationship can be observed in the fasting glucose, LF/HF, cholesterol and high-density lipoprotein (HDL). CONCLUSION: Long-term exposure to traffic-related air pollution may contribute to the development or exacerbation of cardio-metabolic disorders. The mechanisms linking air pollution and cardio-metabolic disorders may be associated with the increased systemic inflammation and oxidative stress, reduced insulin sensitivity and elevated arterial stiffness and blood pressure. SN - 1432-1246 UR - https://www.unboundmedicine.com/medline/citation/27084335/Traffic_related_air_pollution_is_associated_with_cardio_metabolic_biomarkers_in_general_residents_ L2 - https://dx.doi.org/10.1007/s00420-016-1129-3 DB - PRIME DP - Unbound Medicine ER -