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Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder.
Bipolar Disord 2016; 18(3):300-6BD

Abstract

OBJECTIVES

Dietary deficiency in polyunsaturated fatty acids (PUFAs), including the omega-3 fatty acids eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3), and excesses in omega-6 fatty acids, including linoleic acid (LA; 18:2n-6) and arachidonic acid (AA; 20:4n-6), may be associated with the pathophysiology of bipolar disorder. In an effort to provide clarification regarding the relationship between PUFA biostatus and bipolar disorder, this meta-analysis investigated studies comparing erythrocyte (red blood cell) membrane PUFA composition in patients with bipolar disorder and healthy controls.

METHODS

A meta-analysis was performed on case-control studies comparing erythrocyte PUFA (EPA, DHA, LA and AA) levels in patients with bipolar I disorder and healthy controls. Standardized effect sizes were calculated and combined using a random effects model.

RESULTS

Six eligible case-control studies comprising n = 118 bipolar I patients and n = 147 healthy controls were included in the analysis. Compared with healthy controls, patients with bipolar I disorder exhibited robust erythrocyte DHA deficits (p = 0.0008) and there was a trend for lower EPA (p = 0.086). There were no significant differences in LA (p = 0.42) or AA (p = 0.64).

CONCLUSIONS

Bipolar I disorder is associated with robust erythrocyte DHA deficits. These findings add to a growing body of evidence implicating omega-3 PUFA deficiency in the pathophysiology of bipolar disorder.

Authors+Show Affiliations

Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA.Division of Epidemiology and Biostatistics, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

27087497

Citation

McNamara, Robert K., and Jeffrey A. Welge. "Meta-analysis of Erythrocyte Polyunsaturated Fatty Acid Biostatus in Bipolar Disorder." Bipolar Disorders, vol. 18, no. 3, 2016, pp. 300-6.
McNamara RK, Welge JA. Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. Bipolar Disord. 2016;18(3):300-6.
McNamara, R. K., & Welge, J. A. (2016). Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. Bipolar Disorders, 18(3), pp. 300-6. doi:10.1111/bdi.12386.
McNamara RK, Welge JA. Meta-analysis of Erythrocyte Polyunsaturated Fatty Acid Biostatus in Bipolar Disorder. Bipolar Disord. 2016;18(3):300-6. PubMed PMID: 27087497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. AU - McNamara,Robert K, AU - Welge,Jeffrey A, Y1 - 2016/04/18/ PY - 2015/12/18/received PY - 2016/03/03/revised PY - 2016/03/18/accepted PY - 2016/4/19/entrez PY - 2016/4/19/pubmed PY - 2017/9/25/medline KW - arachidonic acid KW - bipolar disorder KW - omega-3 fatty acids KW - omega-6 fatty acids SP - 300 EP - 6 JF - Bipolar disorders JO - Bipolar Disord VL - 18 IS - 3 N2 - OBJECTIVES: Dietary deficiency in polyunsaturated fatty acids (PUFAs), including the omega-3 fatty acids eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3), and excesses in omega-6 fatty acids, including linoleic acid (LA; 18:2n-6) and arachidonic acid (AA; 20:4n-6), may be associated with the pathophysiology of bipolar disorder. In an effort to provide clarification regarding the relationship between PUFA biostatus and bipolar disorder, this meta-analysis investigated studies comparing erythrocyte (red blood cell) membrane PUFA composition in patients with bipolar disorder and healthy controls. METHODS: A meta-analysis was performed on case-control studies comparing erythrocyte PUFA (EPA, DHA, LA and AA) levels in patients with bipolar I disorder and healthy controls. Standardized effect sizes were calculated and combined using a random effects model. RESULTS: Six eligible case-control studies comprising n = 118 bipolar I patients and n = 147 healthy controls were included in the analysis. Compared with healthy controls, patients with bipolar I disorder exhibited robust erythrocyte DHA deficits (p = 0.0008) and there was a trend for lower EPA (p = 0.086). There were no significant differences in LA (p = 0.42) or AA (p = 0.64). CONCLUSIONS: Bipolar I disorder is associated with robust erythrocyte DHA deficits. These findings add to a growing body of evidence implicating omega-3 PUFA deficiency in the pathophysiology of bipolar disorder. SN - 1399-5618 UR - https://www.unboundmedicine.com/medline/citation/27087497/Meta_analysis_of_erythrocyte_polyunsaturated_fatty_acid_biostatus_in_bipolar_disorder_ L2 - https://doi.org/10.1111/bdi.12386 DB - PRIME DP - Unbound Medicine ER -