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The Influence of Palatable Diets in Reward System Activation: A Mini Review.
Adv Pharmacol Sci. 2016; 2016:7238679.AP

Abstract

The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. The cafeteria diet is such a palatable diet and has been shown consistently to increase body weight and induce hyperplasia in animal obesity models. Moreover, palatable high-fat foods (such as those of the cafeteria diet) can induce addiction-like deficits in brain reward function and are considered to be an important source of motivation that might drive overeating and contribute to the development of obesity. The mechanism of neural adaptation triggered by palatable foods is similar to those that have been reported for nondrug addictions and long-term drug use. Thus, this review attempts to describe the potential mechanisms that might lead to highly palatable diets, such as the cafeteria diet, triggering addiction, or compulsion through the reward system.

Authors+Show Affiliations

Pharmacology of Pain and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil; Graduate Program in Biological Sciences-Physiology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil; Graduate Program of Pharmacology and Toxicology, Pontifícia Universidade Católica do Rio Grande do Sul, Institute of Toxicology, 90619-900 Porto Alegre, RS, Brazil.Pharmacology of Pain and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil; Graduate Program in Biological Sciences-Physiology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil; Graduate Program of Pharmacology and Toxicology, Pontifícia Universidade Católica do Rio Grande do Sul, Institute of Toxicology, 90619-900 Porto Alegre, RS, Brazil.Pharmacology of Pain and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil; Graduate Program in Biological Sciences-Physiology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27087806

Citation

de Macedo, Isabel Cristina, et al. "The Influence of Palatable Diets in Reward System Activation: a Mini Review." Advances in Pharmacological Sciences, vol. 2016, 2016, p. 7238679.
de Macedo IC, de Freitas JS, da Silva Torres IL. The Influence of Palatable Diets in Reward System Activation: A Mini Review. Adv Pharmacol Sci. 2016;2016:7238679.
de Macedo, I. C., de Freitas, J. S., & da Silva Torres, I. L. (2016). The Influence of Palatable Diets in Reward System Activation: A Mini Review. Advances in Pharmacological Sciences, 2016, 7238679. https://doi.org/10.1155/2016/7238679
de Macedo IC, de Freitas JS, da Silva Torres IL. The Influence of Palatable Diets in Reward System Activation: a Mini Review. Adv Pharmacol Sci. 2016;2016:7238679. PubMed PMID: 27087806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Influence of Palatable Diets in Reward System Activation: A Mini Review. AU - de Macedo,Isabel Cristina, AU - de Freitas,Joice Soares, AU - da Silva Torres,Iraci Lucena, Y1 - 2016/03/20/ PY - 2015/11/03/received PY - 2016/02/12/revised PY - 2016/02/16/accepted PY - 2016/4/19/entrez PY - 2016/4/19/pubmed PY - 2016/4/19/medline SP - 7238679 EP - 7238679 JF - Advances in pharmacological sciences JO - Adv Pharmacol Sci VL - 2016 N2 - The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. The cafeteria diet is such a palatable diet and has been shown consistently to increase body weight and induce hyperplasia in animal obesity models. Moreover, palatable high-fat foods (such as those of the cafeteria diet) can induce addiction-like deficits in brain reward function and are considered to be an important source of motivation that might drive overeating and contribute to the development of obesity. The mechanism of neural adaptation triggered by palatable foods is similar to those that have been reported for nondrug addictions and long-term drug use. Thus, this review attempts to describe the potential mechanisms that might lead to highly palatable diets, such as the cafeteria diet, triggering addiction, or compulsion through the reward system. SN - 1687-6334 UR - https://www.unboundmedicine.com/medline/citation/27087806/full_citation L2 - https://doi.org/10.1155/2016/7238679 DB - PRIME DP - Unbound Medicine ER -
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