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Carcinoid Syndrome-Induced Ventricular Tachycardia.
Case Rep Cardiol. 2016; 2016:9142598.CR

Abstract

Introduction. Carcinoid tumors are rare neuroendocrine malignancies that secrete multiple bioactive substances. These bioactive substances are responsible for the carcinoid syndrome characterized by diarrhea, flushing, syncope, and right-sided valvular heart disease. Previous case reports have described carcinoid syndrome associated with coronary vasospasm and the well-characterized carcinoid heart disease. Case. Our patient is a 73-year-old female with complex past medical history most notable for metastatic carcinoid tumors diagnosed in 2013-05. She initially presented in 2014-09 with syncope and dizziness associated with sinus pause on an event monitor. She received a pacemaker given normal left ventricular function and was discharged. However, she was readmitted with similar symptoms corresponding to multiple episodes of ventricular tachycardia. She was started on high-dose beta blockade and has had no recurrence of arrhythmia over a follow-up period of 12 months. Conclusion. We hypothesize that the patient's ventricular tachycardia was mediated by the multiple bioactive substances secreted by her carcinoid tumors. Her carcinoid tumor biomarkers were elevated and other explanations for arrhythmia were investigated and ruled out. To our knowledge, this is the first case of ventricular tachycardia mediated by carcinoid syndrome and suppressed by beta-blocker. Further investigation into this relationship is needed.

Authors+Show Affiliations

Department of Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.Department of Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA; Department of Medicine, School of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah 21589, Saudi Arabia.Division of Cardiovascular Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.Division of Cardiovascular Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27088017

Citation

Rupp, Austin B., et al. "Carcinoid Syndrome-Induced Ventricular Tachycardia." Case Reports in Cardiology, vol. 2016, 2016, p. 9142598.
Rupp AB, Ahmadjee A, Morshedzadeh JH, et al. Carcinoid Syndrome-Induced Ventricular Tachycardia. Case Rep Cardiol. 2016;2016:9142598.
Rupp, A. B., Ahmadjee, A., Morshedzadeh, J. H., & Ranjan, R. (2016). Carcinoid Syndrome-Induced Ventricular Tachycardia. Case Reports in Cardiology, 2016, 9142598. https://doi.org/10.1155/2016/9142598
Rupp AB, et al. Carcinoid Syndrome-Induced Ventricular Tachycardia. Case Rep Cardiol. 2016;2016:9142598. PubMed PMID: 27088017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carcinoid Syndrome-Induced Ventricular Tachycardia. AU - Rupp,Austin B, AU - Ahmadjee,Abdulmohsin, AU - Morshedzadeh,Jack H, AU - Ranjan,Ravi, Y1 - 2016/03/21/ PY - 2015/11/30/received PY - 2016/02/23/accepted PY - 2016/4/19/entrez PY - 2016/4/19/pubmed PY - 2016/4/19/medline SP - 9142598 EP - 9142598 JF - Case reports in cardiology JO - Case Rep Cardiol VL - 2016 N2 - Introduction. Carcinoid tumors are rare neuroendocrine malignancies that secrete multiple bioactive substances. These bioactive substances are responsible for the carcinoid syndrome characterized by diarrhea, flushing, syncope, and right-sided valvular heart disease. Previous case reports have described carcinoid syndrome associated with coronary vasospasm and the well-characterized carcinoid heart disease. Case. Our patient is a 73-year-old female with complex past medical history most notable for metastatic carcinoid tumors diagnosed in 2013-05. She initially presented in 2014-09 with syncope and dizziness associated with sinus pause on an event monitor. She received a pacemaker given normal left ventricular function and was discharged. However, she was readmitted with similar symptoms corresponding to multiple episodes of ventricular tachycardia. She was started on high-dose beta blockade and has had no recurrence of arrhythmia over a follow-up period of 12 months. Conclusion. We hypothesize that the patient's ventricular tachycardia was mediated by the multiple bioactive substances secreted by her carcinoid tumors. Her carcinoid tumor biomarkers were elevated and other explanations for arrhythmia were investigated and ruled out. To our knowledge, this is the first case of ventricular tachycardia mediated by carcinoid syndrome and suppressed by beta-blocker. Further investigation into this relationship is needed. SN - 2090-6404 UR - https://www.unboundmedicine.com/medline/citation/27088017/Carcinoid_Syndrome_Induced_Ventricular_Tachycardia_ DB - PRIME DP - Unbound Medicine ER -
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