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NAFLD and Chronic Kidney Disease.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries and it is now considered a risk factor for cardiovascular disease. Evidence linking NAFLD to the development and progression of chronic kidney disease (CKD) is emerging as a popular area of scientific interest. The rise in simultaneous liver-kidney transplantation as well as the significant cost associated with the presence of chronic kidney disease in the NAFLD population make this entity a worthwhile target for screening and therapeutic intervention. While several cross-sectional and case control studies have been published to substantiate these theories, very little data exists on the underlying cause of NAFLD and CKD. In this review, we will discuss the most recent publications on the diagnosis of NAFLD as well new evidence regarding the pathophysiology of NAFLD and CKD as an inflammatory disorder. These mechanisms include the role of obesity, the renin-angiotensin system, and dysregulation of fructose metabolism and lipogenesis in the development of both disorders. Further investigation of these pathways may lead to novel therapies that aim to target the NAFLD and CKD. However, more prospective studies that include information on both renal and liver histology will be necessary in order to understand the relationship between these diseases.

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  • Authors+Show Affiliations

    ,

    Division of Renal Diseases and Hypertension, University of Colorado Hospital, Aurora, CO 80045, USA. morgan.marcuccilli@ucdenver.edu.

    Division of Renal Diseases and Hypertension, University of Colorado Denver, 13199 East Montview Boulevard, Suite 495, Aurora, CO 80045, USA. michel.chonchol@ucdenver.edu.

    Source

    MeSH

    Animals
    Fructose
    Humans
    Inflammation
    Kidney
    Lipogenesis
    Liver
    Non-alcoholic Fatty Liver Disease
    Renal Insufficiency, Chronic
    Renin-Angiotensin System

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    27089331

    Citation

    Marcuccilli, Morgan, and Michel Chonchol. "NAFLD and Chronic Kidney Disease." International Journal of Molecular Sciences, vol. 17, no. 4, 2016, p. 562.
    Marcuccilli M, Chonchol M. NAFLD and Chronic Kidney Disease. Int J Mol Sci. 2016;17(4):562.
    Marcuccilli, M., & Chonchol, M. (2016). NAFLD and Chronic Kidney Disease. International Journal of Molecular Sciences, 17(4), p. 562. doi:10.3390/ijms17040562.
    Marcuccilli M, Chonchol M. NAFLD and Chronic Kidney Disease. Int J Mol Sci. 2016 Apr 14;17(4):562. PubMed PMID: 27089331.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - NAFLD and Chronic Kidney Disease. AU - Marcuccilli,Morgan, AU - Chonchol,Michel, Y1 - 2016/04/14/ PY - 2016/03/01/received PY - 2016/03/25/revised PY - 2016/03/28/accepted PY - 2016/4/19/entrez PY - 2016/4/19/pubmed PY - 2017/1/7/medline KW - chronic kidney disease KW - inflammation KW - non-alcoholic fatty liver disease KW - non-alcoholic steatohepatitis KW - review SP - 562 EP - 562 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 17 IS - 4 N2 - Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries and it is now considered a risk factor for cardiovascular disease. Evidence linking NAFLD to the development and progression of chronic kidney disease (CKD) is emerging as a popular area of scientific interest. The rise in simultaneous liver-kidney transplantation as well as the significant cost associated with the presence of chronic kidney disease in the NAFLD population make this entity a worthwhile target for screening and therapeutic intervention. While several cross-sectional and case control studies have been published to substantiate these theories, very little data exists on the underlying cause of NAFLD and CKD. In this review, we will discuss the most recent publications on the diagnosis of NAFLD as well new evidence regarding the pathophysiology of NAFLD and CKD as an inflammatory disorder. These mechanisms include the role of obesity, the renin-angiotensin system, and dysregulation of fructose metabolism and lipogenesis in the development of both disorders. Further investigation of these pathways may lead to novel therapies that aim to target the NAFLD and CKD. However, more prospective studies that include information on both renal and liver histology will be necessary in order to understand the relationship between these diseases. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/27089331/full_citation L2 - http://www.mdpi.com/resolver?pii=ijms17040562 DB - PRIME DP - Unbound Medicine ER -