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Is outdoor recreational activity an independent predictor of cardiovascular disease mortality - NHANES III?
Nutr Metab Cardiovasc Dis. 2016 08; 26(8):735-42.NM

Abstract

BACKGROUND AND AIMS

To investigate if frequency of outdoor recreational activity (ORA) predicts cardiovascular disease (CVD) mortality, independent of serum 25(OH)D concentration.

METHODS AND RESULTS

Baseline data on ORA and serum 25(OH)D, collected from 11,746 participants aged 30-90 years in the Third National Health and Nutrition Examination Survey during 1988-1994, were linked to the National Death Index for assessment of CVD deaths from baseline through December 2006. CVD mortality as a primary cause of death was assessed during a mean follow up of 12.9 (SD, 4.2) years. There were 1519 CVD deaths during follow up. A strong positive association was observed between frequency of ORA in the last month and serum 25(OH)D (p < 0.001). Compared to participants who did no ORA in the last month, the hazard ratio (HR) of CVD mortality was 0.72 (95% confidence interval 0.58-0.90) for those doing ORA 1-4 times, 0.64 (0.47-0.89) for 5-12 times, 0.70 (0.56-0.89) for 13-30 times and 0.63 (0.47-0.84) for ≥30 times (p-trend < 0.001), in a Cox proportional hazards regression model which included 25(OH)D and CVD risk factors. Serum 25(OH)D was inversely associated with CVD mortality (p-trend, 0.01) in this same model.

CONCLUSIONS

An inverse association between ORA and CVD mortality was observed independent of 25(OH)D. The underlying mechanism for this association may not involve 25(OH)D hence, further studies are warranted to confirm and investigate the underlying mechanism.

Authors+Show Affiliations

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02120, USA; Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, 40202, USA. Electronic address: mdonneyong@partners.org.Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, 40202, USA.Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, 40202, USA.Department of Medicine, University of Louisville, Louisville, KY, 40202, USA.Section of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, Private Bag, 92019, New Zealand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27089974

Citation

Donneyong, M M., et al. "Is Outdoor Recreational Activity an Independent Predictor of Cardiovascular Disease Mortality - NHANES III?" Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 26, no. 8, 2016, pp. 735-42.
Donneyong MM, Taylor KC, Kerber RA, et al. Is outdoor recreational activity an independent predictor of cardiovascular disease mortality - NHANES III? Nutr Metab Cardiovasc Dis. 2016;26(8):735-42.
Donneyong, M. M., Taylor, K. C., Kerber, R. A., Hornung, C. A., & Scragg, R. (2016). Is outdoor recreational activity an independent predictor of cardiovascular disease mortality - NHANES III? Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 26(8), 735-42. https://doi.org/10.1016/j.numecd.2016.02.008
Donneyong MM, et al. Is Outdoor Recreational Activity an Independent Predictor of Cardiovascular Disease Mortality - NHANES III. Nutr Metab Cardiovasc Dis. 2016;26(8):735-42. PubMed PMID: 27089974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is outdoor recreational activity an independent predictor of cardiovascular disease mortality - NHANES III? AU - Donneyong,M M, AU - Taylor,K C, AU - Kerber,R A, AU - Hornung,C A, AU - Scragg,R, Y1 - 2016/03/03/ PY - 2015/07/26/received PY - 2016/02/02/revised PY - 2016/02/05/accepted PY - 2016/4/20/entrez PY - 2016/4/20/pubmed PY - 2017/8/29/medline KW - CVD KW - Outdoor recreational activity KW - Physical activity KW - Vitamin D SP - 735 EP - 42 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 26 IS - 8 N2 - BACKGROUND AND AIMS: To investigate if frequency of outdoor recreational activity (ORA) predicts cardiovascular disease (CVD) mortality, independent of serum 25(OH)D concentration. METHODS AND RESULTS: Baseline data on ORA and serum 25(OH)D, collected from 11,746 participants aged 30-90 years in the Third National Health and Nutrition Examination Survey during 1988-1994, were linked to the National Death Index for assessment of CVD deaths from baseline through December 2006. CVD mortality as a primary cause of death was assessed during a mean follow up of 12.9 (SD, 4.2) years. There were 1519 CVD deaths during follow up. A strong positive association was observed between frequency of ORA in the last month and serum 25(OH)D (p < 0.001). Compared to participants who did no ORA in the last month, the hazard ratio (HR) of CVD mortality was 0.72 (95% confidence interval 0.58-0.90) for those doing ORA 1-4 times, 0.64 (0.47-0.89) for 5-12 times, 0.70 (0.56-0.89) for 13-30 times and 0.63 (0.47-0.84) for ≥30 times (p-trend < 0.001), in a Cox proportional hazards regression model which included 25(OH)D and CVD risk factors. Serum 25(OH)D was inversely associated with CVD mortality (p-trend, 0.01) in this same model. CONCLUSIONS: An inverse association between ORA and CVD mortality was observed independent of 25(OH)D. The underlying mechanism for this association may not involve 25(OH)D hence, further studies are warranted to confirm and investigate the underlying mechanism. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/27089974/Is_outdoor_recreational_activity_an_independent_predictor_of_cardiovascular_disease_mortality___NHANES_III L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(15)30135-6 DB - PRIME DP - Unbound Medicine ER -