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Diagnostic significance of serum galectin-3 levels in heart failure with preserved ejection fraction.
Acta Cardiol. 2016 Apr; 71(2):191-7.AC

Abstract

OBJECTIVE

Galectin-3, reflecting cardiac fibrosis, is a promising biomarker in early detection of heart failure with preserved ejection fraction (HFpEF). We aimed to clarify the clinical utility of galectin-3 levels in the diagnosis of HFpEF and to compare galectin-3 with N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels.

METHODS AND RESULTS

The study included 44 HFpEF patients (mean age 60 ± 6.78 years, 24 men) and 38 control subjects (mean age 57 ± 8.98 years, 20 men). Galectin-3 and NT-proBNP levels were assessed by the ELISA kits. The receiver operating characteristics (ROC) curve was used to examine the diagnostic performance of galectin-3 and NT-proBNP in HFpEF. Galectin-3 and NT-proBNP levels were significantly increased in patients with HFpEF compared to controls [5.35 ng/ml (0.86 – 14.90) vs 0.51 ng/ml (0.15 – 1.71) P < 0.0001, 617.75 ± 271.30 pg/ml vs 66.35 ± 54.01 pg/ml P < 0.0001, respectively]. Galectin-3 correlated with NT-proBNP, left atrial volume index, left ventricular mass index, and E/E’ (r = 0.90, P < 0.0001; r = 0.75, P = 0.0001; r = 0.86, P = 0.0001; r = 0.80, P = 0.0001; respectively). The area under the ROC curve was 0.98 for galectin-3 and 1.0 for NT-proBNP.

CONCLUSIONS

Our results support that, in addition to NT-proBNP, galectin-3 is also a valuable biomarker for the diagnosis of patients with HFpEF.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27090041

Citation

Polat, Veli, et al. "Diagnostic Significance of Serum Galectin-3 Levels in Heart Failure With Preserved Ejection Fraction." Acta Cardiologica, vol. 71, no. 2, 2016, pp. 191-7.
Polat V, Bozcali E, Uygun T, et al. Diagnostic significance of serum galectin-3 levels in heart failure with preserved ejection fraction. Acta Cardiol. 2016;71(2):191-7.
Polat, V., Bozcali, E., Uygun, T., Opan, S., & Karakaya, O. (2016). Diagnostic significance of serum galectin-3 levels in heart failure with preserved ejection fraction. Acta Cardiologica, 71(2), 191-7. https://doi.org/10.2143/AC.71.2.3141849
Polat V, et al. Diagnostic Significance of Serum Galectin-3 Levels in Heart Failure With Preserved Ejection Fraction. Acta Cardiol. 2016;71(2):191-7. PubMed PMID: 27090041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic significance of serum galectin-3 levels in heart failure with preserved ejection fraction. AU - Polat,Veli, AU - Bozcali,Evin, AU - Uygun,Turgut, AU - Opan,Selcuk, AU - Karakaya,Osman, PY - 2016/4/20/entrez PY - 2016/4/20/pubmed PY - 2016/6/3/medline KW - Galectin-3 KW - cardiac fibrosis KW - diagnosis KW - heart failure with preserved ejection fraction SP - 191 EP - 7 JF - Acta cardiologica JO - Acta Cardiol VL - 71 IS - 2 N2 - OBJECTIVE: Galectin-3, reflecting cardiac fibrosis, is a promising biomarker in early detection of heart failure with preserved ejection fraction (HFpEF). We aimed to clarify the clinical utility of galectin-3 levels in the diagnosis of HFpEF and to compare galectin-3 with N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels. METHODS AND RESULTS: The study included 44 HFpEF patients (mean age 60 ± 6.78 years, 24 men) and 38 control subjects (mean age 57 ± 8.98 years, 20 men). Galectin-3 and NT-proBNP levels were assessed by the ELISA kits. The receiver operating characteristics (ROC) curve was used to examine the diagnostic performance of galectin-3 and NT-proBNP in HFpEF. Galectin-3 and NT-proBNP levels were significantly increased in patients with HFpEF compared to controls [5.35 ng/ml (0.86 – 14.90) vs 0.51 ng/ml (0.15 – 1.71) P < 0.0001, 617.75 ± 271.30 pg/ml vs 66.35 ± 54.01 pg/ml P < 0.0001, respectively]. Galectin-3 correlated with NT-proBNP, left atrial volume index, left ventricular mass index, and E/E’ (r = 0.90, P < 0.0001; r = 0.75, P = 0.0001; r = 0.86, P = 0.0001; r = 0.80, P = 0.0001; respectively). The area under the ROC curve was 0.98 for galectin-3 and 1.0 for NT-proBNP. CONCLUSIONS: Our results support that, in addition to NT-proBNP, galectin-3 is also a valuable biomarker for the diagnosis of patients with HFpEF. SN - 0001-5385 UR - https://www.unboundmedicine.com/medline/citation/27090041/Diagnostic_significance_of_serum_galectin_3_levels_in_heart_failure_with_preserved_ejection_fraction_ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -