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Severely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis.

Abstract

Information was obtained on stressful life circumstances, using the Life Events and Difficulties Schedule (LEDS) from 39 patients with early multiple sclerosis and 40 matched nonpatient volunteers. The proportion of multiple sclerosis patients who experienced marked life adversity in the year prior to onset of symptoms was significantly higher than for nonpatients in the year before interview (77% vs. 35%). The excess in marked life stress was most evident in the 6 months before onset. Such stressors might explain the timing of symptom exacerbation for some patients with multiple sclerosis, perhaps by perturbing an already unstable neuroimmunological system.

Authors+Show Affiliations

San Diego V.A. Medical Center, Psychiatry Service, CA 92161.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

2709039

Citation

Grant, I, et al. "Severely Threatening Events and Marked Life Difficulties Preceding Onset or Exacerbation of Multiple Sclerosis." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 52, no. 1, 1989, pp. 8-13.
Grant I, Brown GW, Harris T, et al. Severely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1989;52(1):8-13.
Grant, I., Brown, G. W., Harris, T., McDonald, W. I., Patterson, T., & Trimble, M. R. (1989). Severely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry, 52(1), pp. 8-13.
Grant I, et al. Severely Threatening Events and Marked Life Difficulties Preceding Onset or Exacerbation of Multiple Sclerosis. J Neurol Neurosurg Psychiatry. 1989;52(1):8-13. PubMed PMID: 2709039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis. AU - Grant,I, AU - Brown,G W, AU - Harris,T, AU - McDonald,W I, AU - Patterson,T, AU - Trimble,M R, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 8 EP - 13 JF - Journal of neurology, neurosurgery, and psychiatry JO - J. Neurol. Neurosurg. Psychiatry VL - 52 IS - 1 N2 - Information was obtained on stressful life circumstances, using the Life Events and Difficulties Schedule (LEDS) from 39 patients with early multiple sclerosis and 40 matched nonpatient volunteers. The proportion of multiple sclerosis patients who experienced marked life adversity in the year prior to onset of symptoms was significantly higher than for nonpatients in the year before interview (77% vs. 35%). The excess in marked life stress was most evident in the 6 months before onset. Such stressors might explain the timing of symptom exacerbation for some patients with multiple sclerosis, perhaps by perturbing an already unstable neuroimmunological system. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/2709039/Severely_threatening_events_and_marked_life_difficulties_preceding_onset_or_exacerbation_of_multiple_sclerosis_ L2 - http://jnnp.bmj.com/cgi/pmidlookup?view=long&pmid=2709039 DB - PRIME DP - Unbound Medicine ER -