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Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans.
Exp Gerontol 2016; 80:43-50EG

Abstract

Pyrroloquinoline quinone (PQQ) is linked to fundamental biological processes such as mitochondrial biogenesis and lipid metabolism. PQQ may also function as an essential micronutrient during animal development. Recent studies have shown the therapeutic potential of PQQ for several age-related diseases due to its antioxidant capacity. However, whether PQQ can promote longevity is unknown. Here, we investigate the effects of PQQ on oxidative stress resistance as well as lifespan modulation in Caenorhabditis elegans. We find that PQQ enhances resistance to oxidative stress and extends the lifespan of C. elegans at optimal doses. The underlying molecular mechanism involves the increased activities of the primary lifespan extension transcriptional factors DAF-16/FOXO, the conserved oxidative stress-responsive transcription factor SKN-1/Nrf2, and upregulation of daf-16, skn-1 downstream targets including sod-3, hsp16.2, gst-1 and gst-10. Our findings uncover a novel role of PQQ in longevity, supporting PQQ as a possible dietary supplement for overall health improvement.

Authors+Show Affiliations

Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China; Institute of Integrated Traditional Chinese and Medicine and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.Institute of Integrated Traditional Chinese and Medicine and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.Department of Maternal-Fetal Medicine Pregnancy Research Centre, University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville 3052, Australia.Department of Maternal-Fetal Medicine Pregnancy Research Centre, University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville 3052, Australia.Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China. Electronic address: xiashijinhd@163.com.Institute of Integrated Traditional Chinese and Medicine and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: caiwaijiao@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27090484

Citation

Wu, J Z., et al. "Pyrroloquinoline Quinone Enhances the Resistance to Oxidative Stress and Extends Lifespan Upon DAF-16 and SKN-1 Activities in C. Elegans." Experimental Gerontology, vol. 80, 2016, pp. 43-50.
Wu JZ, Huang JH, Khanabdali R, et al. Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans. Exp Gerontol. 2016;80:43-50.
Wu, J. Z., Huang, J. H., Khanabdali, R., Kalionis, B., Xia, S. J., & Cai, W. J. (2016). Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans. Experimental Gerontology, 80, pp. 43-50. doi:10.1016/j.exger.2016.04.008.
Wu JZ, et al. Pyrroloquinoline Quinone Enhances the Resistance to Oxidative Stress and Extends Lifespan Upon DAF-16 and SKN-1 Activities in C. Elegans. Exp Gerontol. 2016;80:43-50. PubMed PMID: 27090484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans. AU - Wu,J Z, AU - Huang,J H, AU - Khanabdali,R, AU - Kalionis,B, AU - Xia,S J, AU - Cai,W J, Y1 - 2016/04/14/ PY - 2015/11/14/received PY - 2016/03/18/revised PY - 2016/04/09/accepted PY - 2016/4/20/entrez PY - 2016/4/20/pubmed PY - 2017/9/29/medline KW - C. elegans KW - IIS signalling KW - Lifespan KW - Oxidative stress KW - Pyrroloquinoline quinone SP - 43 EP - 50 JF - Experimental gerontology JO - Exp. Gerontol. VL - 80 N2 - Pyrroloquinoline quinone (PQQ) is linked to fundamental biological processes such as mitochondrial biogenesis and lipid metabolism. PQQ may also function as an essential micronutrient during animal development. Recent studies have shown the therapeutic potential of PQQ for several age-related diseases due to its antioxidant capacity. However, whether PQQ can promote longevity is unknown. Here, we investigate the effects of PQQ on oxidative stress resistance as well as lifespan modulation in Caenorhabditis elegans. We find that PQQ enhances resistance to oxidative stress and extends the lifespan of C. elegans at optimal doses. The underlying molecular mechanism involves the increased activities of the primary lifespan extension transcriptional factors DAF-16/FOXO, the conserved oxidative stress-responsive transcription factor SKN-1/Nrf2, and upregulation of daf-16, skn-1 downstream targets including sod-3, hsp16.2, gst-1 and gst-10. Our findings uncover a novel role of PQQ in longevity, supporting PQQ as a possible dietary supplement for overall health improvement. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/27090484/Pyrroloquinoline_quinone_enhances_the_resistance_to_oxidative_stress_and_extends_lifespan_upon_DAF_16_and_SKN_1_activities_in_C__elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(16)30097-3 DB - PRIME DP - Unbound Medicine ER -