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Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk.
Mov Disord. 2016 07; 31(7):972-8.MD

Abstract

BACKGROUND

Low vitamin D levels are common among patients with Parkinson's disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. The objective of this study was to prospectively assess the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort.

METHODS

Serum samples were collected in 1990-1992, and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association between serum 25-hydroxyvitamin D concentrations and PD risk, regardless of how serum 25-hydroxyvitamin D was modeled. Compared with participants with serum 25-hydroxyvitamin D < 20 ng/mL, the hazards ratio for PD was 1.05 (95% confidence interval, 0.58-1.90) for 20-30 ng/mL and 1.14 (95% confidence interval, 0.59- 2.23) for ≥30 ng/mL. Similar results were obtained in sensitivity analyses that included white participants only and that were stratified by the length of follow-up.

CONCLUSION

This prospective study lends no support to the hypothesis that vitamin D may reduce the risk of PD. © 2016 International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.Department of Neurology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, USA.Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27090608

Citation

Shrestha, Srishti, et al. "Serum 25-hydroxyvitamin D Concentrations in Mid-adulthood and Parkinson's Disease Risk." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 31, no. 7, 2016, pp. 972-8.
Shrestha S, Lutsey PL, Alonso A, et al. Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk. Mov Disord. 2016;31(7):972-8.
Shrestha, S., Lutsey, P. L., Alonso, A., Huang, X., Mosley, T. H., & Chen, H. (2016). Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk. Movement Disorders : Official Journal of the Movement Disorder Society, 31(7), 972-8. https://doi.org/10.1002/mds.26573
Shrestha S, et al. Serum 25-hydroxyvitamin D Concentrations in Mid-adulthood and Parkinson's Disease Risk. Mov Disord. 2016;31(7):972-8. PubMed PMID: 27090608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk. AU - Shrestha,Srishti, AU - Lutsey,Pamela L, AU - Alonso,Alvaro, AU - Huang,Xuemei, AU - Mosley,Thomas H,Jr AU - Chen,Honglei, Y1 - 2016/04/19/ PY - 2014/09/29/received PY - 2015/12/01/revised PY - 2015/12/30/accepted PY - 2016/4/20/entrez PY - 2016/4/20/pubmed PY - 2017/12/30/medline KW - Parkinson's disease KW - cohort study KW - vitamin D SP - 972 EP - 8 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 31 IS - 7 N2 - BACKGROUND: Low vitamin D levels are common among patients with Parkinson's disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. The objective of this study was to prospectively assess the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort. METHODS: Serum samples were collected in 1990-1992, and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association between serum 25-hydroxyvitamin D concentrations and PD risk, regardless of how serum 25-hydroxyvitamin D was modeled. Compared with participants with serum 25-hydroxyvitamin D < 20 ng/mL, the hazards ratio for PD was 1.05 (95% confidence interval, 0.58-1.90) for 20-30 ng/mL and 1.14 (95% confidence interval, 0.59- 2.23) for ≥30 ng/mL. Similar results were obtained in sensitivity analyses that included white participants only and that were stratified by the length of follow-up. CONCLUSION: This prospective study lends no support to the hypothesis that vitamin D may reduce the risk of PD. © 2016 International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/27090608/Serum_25_hydroxyvitamin_D_concentrations_in_Mid_adulthood_and_Parkinson's_disease_risk_ L2 - https://doi.org/10.1002/mds.26573 DB - PRIME DP - Unbound Medicine ER -