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Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis.
Digestion. 2016; 93(3):221-8.D

Abstract

AIM

To elucidate the prevalence and risk factors of gallstone disease (GD) among patients with liver disease and explore their association with the aetiology and severity of hepatic injury.

METHODS

We analysed 4,832 subjects of hepatic injury induced by one of the following aetiologies: hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, excessive alcohol consumption. The risk factors significantly associated with GD were analysed using stepwise logistic regression analysis, the influence of aetiology and severity of liver disease on the prevalence of GD were assessed by multiple logistic regression analysis adjusting for confounding factors.

RESULTS

Three thousand forty eight patients were of positive HBV surface antigen alone with a prevalence of GD of 18.6%, 526 were tested as positive Anti-HCV alone with a prevalence of GD of 22.4%, and 1,258 were identified with excessive alcohol consumption patterns with a prevalence of GD of 13.5%. In each aetiological category, the prevalence of GD increased by age. Stepwise logistic regression analysis showed that age, female, low-density lipoprotein-cholesterol (LDL-Cho), family history of GD, HBV infection, HCV infection, chronic hepatitis and cirrhosis were independent factors associated with GD. After adjusting for age, LDL-Cho and family history of GD, the prevalence of gallstone disease was significantly associated with HCV-related cirrhosis in both genders, HBV-related cirrhosis in males and alcohol-related cirrhosis in females compared with patients with less severe liver disease [corrected]. After adjusting for gender, age, LDL-Cho and family history of GD, patients with HCV-related cirrhosis (OR 2.66, 95% CI 1.49-3.84) but not HBV-related cirrhosis (OR 1.52, 95% CI 0.73-1.82) were more likely to have GD compared with alcohol-related cirrhosis.

CONCLUSION

HCV infection is positively associated with gallstone formation especially in those with cirrhosis patients.

Authors+Show Affiliations

Department of Gastroenterology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27093174

Citation

Zhang, Fen-Ming, et al. "Hepatitis C Virus Infection Is Positively Associated With Gallstones in Liver Cirrhosis." Digestion, vol. 93, no. 3, 2016, pp. 221-8.
Zhang FM, Chen LH, Chen HT, et al. Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis. Digestion. 2016;93(3):221-8.
Zhang, F. M., Chen, L. H., Chen, H. T., Shan, G. D., Hu, F. L., Yang, M., Chen, W. G., & Xu, G. Q. (2016). Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis. Digestion, 93(3), 221-8. https://doi.org/10.1159/000444252
Zhang FM, et al. Hepatitis C Virus Infection Is Positively Associated With Gallstones in Liver Cirrhosis. Digestion. 2016;93(3):221-8. PubMed PMID: 27093174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis. AU - Zhang,Fen-Ming, AU - Chen,Li-Hua, AU - Chen,Hong-Tan, AU - Shan,Guo-Dong, AU - Hu,Feng-Ling, AU - Yang,Ming, AU - Chen,Wen-Guo, AU - Xu,Guo-Qiang, Y1 - 2016/04/19/ PY - 2015/08/06/received PY - 2016/01/26/accepted PY - 2016/4/20/entrez PY - 2016/4/20/pubmed PY - 2017/3/7/medline SP - 221 EP - 8 JF - Digestion JO - Digestion VL - 93 IS - 3 N2 - AIM: To elucidate the prevalence and risk factors of gallstone disease (GD) among patients with liver disease and explore their association with the aetiology and severity of hepatic injury. METHODS: We analysed 4,832 subjects of hepatic injury induced by one of the following aetiologies: hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, excessive alcohol consumption. The risk factors significantly associated with GD were analysed using stepwise logistic regression analysis, the influence of aetiology and severity of liver disease on the prevalence of GD were assessed by multiple logistic regression analysis adjusting for confounding factors. RESULTS: Three thousand forty eight patients were of positive HBV surface antigen alone with a prevalence of GD of 18.6%, 526 were tested as positive Anti-HCV alone with a prevalence of GD of 22.4%, and 1,258 were identified with excessive alcohol consumption patterns with a prevalence of GD of 13.5%. In each aetiological category, the prevalence of GD increased by age. Stepwise logistic regression analysis showed that age, female, low-density lipoprotein-cholesterol (LDL-Cho), family history of GD, HBV infection, HCV infection, chronic hepatitis and cirrhosis were independent factors associated with GD. After adjusting for age, LDL-Cho and family history of GD, the prevalence of gallstone disease was significantly associated with HCV-related cirrhosis in both genders, HBV-related cirrhosis in males and alcohol-related cirrhosis in females compared with patients with less severe liver disease [corrected]. After adjusting for gender, age, LDL-Cho and family history of GD, patients with HCV-related cirrhosis (OR 2.66, 95% CI 1.49-3.84) but not HBV-related cirrhosis (OR 1.52, 95% CI 0.73-1.82) were more likely to have GD compared with alcohol-related cirrhosis. CONCLUSION: HCV infection is positively associated with gallstone formation especially in those with cirrhosis patients. SN - 1421-9867 UR - https://www.unboundmedicine.com/medline/citation/27093174/Hepatitis_C_Virus_Infection_Is_Positively_Associated_with_Gallstones_in_Liver_Cirrhosis_ L2 - https://www.karger.com?DOI=10.1159/000444252 DB - PRIME DP - Unbound Medicine ER -