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Trends in motor neuron disease: association with latitude and air lead levels in Spain.
Neurol Sci. 2016 Aug; 37(8):1271-5.NS

Abstract

Motor neuron diseases (MND) are a group of disorders characterized by motor neuron degeneration. Among them, amyotrophic lateral sclerosis (ALS) is by far the most common in adulthood. This paper assesses the trend and geographical pattern in MND incidence in Spain and the possible air lead levels effect on this pathology. To confirm this concept, we performed a retrospective analysis of the deaths due to MND in Spain during 2000 and 2013, determined the geographical differences, and explored the relationship between MND and the air levels of lead. Overall, between 2000 and 2013, 11,355 people died in Spain because of MND. Disease mortality significantly increased in recent years (2007-2013) when compared with the first time of the period. Spearman's rank correlation coefficient also showed a statistically significant positive trend (CC = 0.824, p = 0.0002). Among people over 65 years, mortality rates were higher in Northern provinces. Moreover, we found a significant association of MND mortality with higher air lead levels (CC = 0.457, p = 0.01). Our study confirms that MND mortality is increasing in Spain, with a significant latitude gradient, which suggests an important role of environmental exposures. This ecological study suggests that air lead levels may be implicated in ALS pathogenesis.

Authors+Show Affiliations

Unit of Legal Medicine, Department of Physiology and Pharmacology, University of Cantabria, Av Cardenal Herrera Oria s/n, 39011, Santander, Spain. ana.santurtun@unican.es.Ticnor SL, Santander, Spain.Neurodegenerative diseases area, Biodonostia Health Research Institute, San Sebastian, Spain.Service of Neurology, University Hospital Marqués de Valdecilla-IDIVAL (CIBERNED), Santander, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27098242

Citation

Santurtún, Ana, et al. "Trends in Motor Neuron Disease: Association With Latitude and Air Lead Levels in Spain." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 37, no. 8, 2016, pp. 1271-5.
Santurtún A, Villar A, Delgado-Alvarado M, et al. Trends in motor neuron disease: association with latitude and air lead levels in Spain. Neurol Sci. 2016;37(8):1271-5.
Santurtún, A., Villar, A., Delgado-Alvarado, M., & Riancho, J. (2016). Trends in motor neuron disease: association with latitude and air lead levels in Spain. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 37(8), 1271-5. https://doi.org/10.1007/s10072-016-2581-2
Santurtún A, et al. Trends in Motor Neuron Disease: Association With Latitude and Air Lead Levels in Spain. Neurol Sci. 2016;37(8):1271-5. PubMed PMID: 27098242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in motor neuron disease: association with latitude and air lead levels in Spain. AU - Santurtún,Ana, AU - Villar,Alejandro, AU - Delgado-Alvarado,Manuel, AU - Riancho,Javier, Y1 - 2016/04/20/ PY - 2016/02/17/received PY - 2016/04/11/accepted PY - 2016/4/22/entrez PY - 2016/4/22/pubmed PY - 2017/1/27/medline KW - ALS KW - Lead KW - Motor neuron disease SP - 1271 EP - 5 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol. Sci. VL - 37 IS - 8 N2 - Motor neuron diseases (MND) are a group of disorders characterized by motor neuron degeneration. Among them, amyotrophic lateral sclerosis (ALS) is by far the most common in adulthood. This paper assesses the trend and geographical pattern in MND incidence in Spain and the possible air lead levels effect on this pathology. To confirm this concept, we performed a retrospective analysis of the deaths due to MND in Spain during 2000 and 2013, determined the geographical differences, and explored the relationship between MND and the air levels of lead. Overall, between 2000 and 2013, 11,355 people died in Spain because of MND. Disease mortality significantly increased in recent years (2007-2013) when compared with the first time of the period. Spearman's rank correlation coefficient also showed a statistically significant positive trend (CC = 0.824, p = 0.0002). Among people over 65 years, mortality rates were higher in Northern provinces. Moreover, we found a significant association of MND mortality with higher air lead levels (CC = 0.457, p = 0.01). Our study confirms that MND mortality is increasing in Spain, with a significant latitude gradient, which suggests an important role of environmental exposures. This ecological study suggests that air lead levels may be implicated in ALS pathogenesis. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/27098242/Trends_in_motor_neuron_disease:_association_with_latitude_and_air_lead_levels_in_Spain_ L2 - https://dx.doi.org/10.1007/s10072-016-2581-2 DB - PRIME DP - Unbound Medicine ER -