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The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin-Beck disease.
Biomarkers. 2016 Jul; 21(5):409-15.B

Abstract

We aimed to verify the levels of IGFBP2 and SOCS3 in cartilage and chondrocytes of Kashin-Beck disease (KBD) patients and the effects of different selenium concentrations on the protein expression levels. Chondrocytes were cultured with sodium selenite in vitro. Immunohistochemistry and western blotting were used to verify the protein expressions. IGFBP2 and SOCS3 were up-regulated in KBD chondrocytes and decreased with increasing selenium concentrations. IGFBP2 expressed highest in the middle zone of KBD cartilage, SOCS3 expressed higher in the middle and deep zone. IGFBP2 and SOCS3 may be the biomarkers for KBD diagnosis and evaluating the effect of selenium supplement.

Authors+Show Affiliations

a School of Public Health, Health Science Center of Xi'an Jiaotong University , Xi'an , PR China and. b Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission , Xi'an , PR China.a School of Public Health, Health Science Center of Xi'an Jiaotong University , Xi'an , PR China and. b Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission , Xi'an , PR China.a School of Public Health, Health Science Center of Xi'an Jiaotong University , Xi'an , PR China and. b Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission , Xi'an , PR China.a School of Public Health, Health Science Center of Xi'an Jiaotong University , Xi'an , PR China and. b Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission , Xi'an , PR China.a School of Public Health, Health Science Center of Xi'an Jiaotong University , Xi'an , PR China and. b Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission , Xi'an , PR China.a School of Public Health, Health Science Center of Xi'an Jiaotong University , Xi'an , PR China and.a School of Public Health, Health Science Center of Xi'an Jiaotong University , Xi'an , PR China and. b Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission , Xi'an , PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27099071

Citation

Wang, Sen, et al. "The Roles of Selenium, Insulin-like Growth Factor Binding Protein 2 and Suppressor of Cytokine Signaling 3 in the Pathogenesis of Kashin-Beck Disease." Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, vol. 21, no. 5, 2016, pp. 409-15.
Wang S, Duan C, Liu H, et al. The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin-Beck disease. Biomarkers. 2016;21(5):409-15.
Wang, S., Duan, C., Liu, H., Shao, W., Wu, C., Han, J., & Guo, X. (2016). The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin-Beck disease. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 21(5), 409-15. https://doi.org/10.3109/1354750X.2016.1141990
Wang S, et al. The Roles of Selenium, Insulin-like Growth Factor Binding Protein 2 and Suppressor of Cytokine Signaling 3 in the Pathogenesis of Kashin-Beck Disease. Biomarkers. 2016;21(5):409-15. PubMed PMID: 27099071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin-Beck disease. AU - Wang,Sen, AU - Duan,Chen, AU - Liu,Huan, AU - Shao,Wanzhen, AU - Wu,Cuiyan, AU - Han,Jing, AU - Guo,Xiong, Y1 - 2016/04/21/ PY - 2016/4/22/entrez PY - 2016/4/22/pubmed PY - 2017/1/24/medline KW - Biomarker KW - IGF-1 signaling pathway KW - IGFBP2 KW - SOCS3 KW - chondrocyte KW - osteoarthropathy SP - 409 EP - 15 JF - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals JO - Biomarkers VL - 21 IS - 5 N2 - We aimed to verify the levels of IGFBP2 and SOCS3 in cartilage and chondrocytes of Kashin-Beck disease (KBD) patients and the effects of different selenium concentrations on the protein expression levels. Chondrocytes were cultured with sodium selenite in vitro. Immunohistochemistry and western blotting were used to verify the protein expressions. IGFBP2 and SOCS3 were up-regulated in KBD chondrocytes and decreased with increasing selenium concentrations. IGFBP2 expressed highest in the middle zone of KBD cartilage, SOCS3 expressed higher in the middle and deep zone. IGFBP2 and SOCS3 may be the biomarkers for KBD diagnosis and evaluating the effect of selenium supplement. SN - 1366-5804 UR - https://www.unboundmedicine.com/medline/citation/27099071/The_roles_of_selenium_insulin_like_growth_factor_binding_protein_2_and_suppressor_of_cytokine_signaling_3_in_the_pathogenesis_of_Kashin_Beck_disease_ L2 - http://www.tandfonline.com/doi/full/10.3109/1354750X.2016.1141990 DB - PRIME DP - Unbound Medicine ER -