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Clinical Pattern of Early-Onset Inflammatory Bowel Disease in Saudi Arabia: A Multicenter National Study.
Inflamm Bowel Dis 2016; 22(8):1961-70IB

Abstract

BACKGROUND

The objectives of this multicenter national study were to compare the clinical phenotype of early-onset inflammatory bowel disease (IBD) (EO-IBD) with IBD in older children and to examine whether there is any variability in consanguinity rate and familial aggregation in EO-IBD compared with later onset IBD.

METHODS

A retrospective analysis was performed on children aged 0 to 14 years with IBD in 17 centers located in geographically distinct regions in Saudi Arabia, from 2003 to 2012. Data of patients with EO-IBD (0 to <6 yrs) were compared with those with later onset IBD (6-14 yrs). Moreover, we evaluated differences in clinical pattern of infantile or toddler onset IBD subgroup (0-3 yr) as compared with those presenting in older children.

RESULTS

Of 352 IBD patients identified during the 10-year study period, 76 children (21.6%) younger than 6 years were diagnosed with IBD. Among the Crohn's disease (CD) group, infantile or toddler onset CD subgroup showed a more frequent isolated colonic involvement (L2) than later-onset group (57% versus 20%; P = 0.002). Positive family history was significantly more common in the infantile or toddler onset ulcerative colitis subgroup (29.4% versus 4.2% in later onset ulcerative colitis; P < 0.0001). The consanguinity rate was significantly higher in the infantile or toddler onset CD subgroup as compared with later onset CD group (57.1% versus 25.3%; P = 0.04).

CONCLUSIONS

In conclusion, EO-IBD exhibits a unique clinical phenotype with a strikingly higher familial aggregation in early-onset ulcerative colitis. Our data suggest a significant genetic impact on the onset of CD in the very young children.

Authors+Show Affiliations

*Division of Pediatric Gastroenterology, Children's Specialized Hospital, King Fahad Medical City, University of King Saud Bin Abdulaziz for Health Sciences, Riyadh, Saudi Arabia;†Department of Pediatrics, Gastroenterology Unit, King Saud University, Riyadh, Saudi Arabia;‡Department of Pediatric Gastroenterology, King Abdullah International Medical Research Center, National Guard Hospital-WR, King Saud Bin Abdulaziz University for Health Sceinces, Jeddah, Saudi Arabia;§Section of Pediatric Gastroenterology, Department of Pediatircs, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia;¶Section of Pediatric Gastroenterology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia;**Division of Pediatric Gastroenterology, Department of Pediatrics, Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah, Saudi Arabia; and††Division of Pediatric Gastroenterology, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27104817

Citation

Al-Hussaini, Abdulrahman, et al. "Clinical Pattern of Early-Onset Inflammatory Bowel Disease in Saudi Arabia: a Multicenter National Study." Inflammatory Bowel Diseases, vol. 22, no. 8, 2016, pp. 1961-70.
Al-Hussaini A, El Mouzan M, Hasosah M, et al. Clinical Pattern of Early-Onset Inflammatory Bowel Disease in Saudi Arabia: A Multicenter National Study. Inflamm Bowel Dis. 2016;22(8):1961-70.
Al-Hussaini, A., El Mouzan, M., Hasosah, M., Al-Mehaidib, A., ALSaleem, K., Saadah, O. I., & Al-Edreesi, M. (2016). Clinical Pattern of Early-Onset Inflammatory Bowel Disease in Saudi Arabia: A Multicenter National Study. Inflammatory Bowel Diseases, 22(8), pp. 1961-70. doi:10.1097/MIB.0000000000000796.
Al-Hussaini A, et al. Clinical Pattern of Early-Onset Inflammatory Bowel Disease in Saudi Arabia: a Multicenter National Study. Inflamm Bowel Dis. 2016;22(8):1961-70. PubMed PMID: 27104817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Pattern of Early-Onset Inflammatory Bowel Disease in Saudi Arabia: A Multicenter National Study. AU - Al-Hussaini,Abdulrahman, AU - El Mouzan,Mohammad, AU - Hasosah,Mohammed, AU - Al-Mehaidib,Ali, AU - ALSaleem,Khalid, AU - Saadah,Omar I, AU - Al-Edreesi,Mohammed, PY - 2016/4/23/entrez PY - 2016/4/23/pubmed PY - 2018/2/3/medline SP - 1961 EP - 70 JF - Inflammatory bowel diseases JO - Inflamm. Bowel Dis. VL - 22 IS - 8 N2 - BACKGROUND: The objectives of this multicenter national study were to compare the clinical phenotype of early-onset inflammatory bowel disease (IBD) (EO-IBD) with IBD in older children and to examine whether there is any variability in consanguinity rate and familial aggregation in EO-IBD compared with later onset IBD. METHODS: A retrospective analysis was performed on children aged 0 to 14 years with IBD in 17 centers located in geographically distinct regions in Saudi Arabia, from 2003 to 2012. Data of patients with EO-IBD (0 to <6 yrs) were compared with those with later onset IBD (6-14 yrs). Moreover, we evaluated differences in clinical pattern of infantile or toddler onset IBD subgroup (0-3 yr) as compared with those presenting in older children. RESULTS: Of 352 IBD patients identified during the 10-year study period, 76 children (21.6%) younger than 6 years were diagnosed with IBD. Among the Crohn's disease (CD) group, infantile or toddler onset CD subgroup showed a more frequent isolated colonic involvement (L2) than later-onset group (57% versus 20%; P = 0.002). Positive family history was significantly more common in the infantile or toddler onset ulcerative colitis subgroup (29.4% versus 4.2% in later onset ulcerative colitis; P < 0.0001). The consanguinity rate was significantly higher in the infantile or toddler onset CD subgroup as compared with later onset CD group (57.1% versus 25.3%; P = 0.04). CONCLUSIONS: In conclusion, EO-IBD exhibits a unique clinical phenotype with a strikingly higher familial aggregation in early-onset ulcerative colitis. Our data suggest a significant genetic impact on the onset of CD in the very young children. SN - 1536-4844 UR - https://www.unboundmedicine.com/medline/citation/27104817/Clinical_Pattern_of_Early_Onset_Inflammatory_Bowel_Disease_in_Saudi_Arabia:_A_Multicenter_National_Study_ L2 - https://academic.oup.com/ibdjournal/article-lookup/doi/10.1097/MIB.0000000000000796 DB - PRIME DP - Unbound Medicine ER -