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The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis.
Neuroepidemiology. 2016; 46(4):292-300.N

Abstract

BACKGROUND

Parkinson's disease (PD) is a common neurodegenerative disorder. Epidemiological studies on the incidence of PD are important to better understand the risk factors for PD and determine the condition's natural history.

OBJECTIVE

This systematic review and meta-analysis examine the incidence of PD and its variation by age and gender.

METHODS

We searched MEDLINE and EMBASE for epidemiologic studies of PD from 2001 to 2014, as a previously published systematic review included studies published until 2001. Data were analyzed separately for age group and gender, and meta-regression was used to determine whether a significant difference was present between groups.

RESULTS

Twenty-seven studies were included in the analysis. Meta-analysis of international studies showed rising incidence with age in both men and women. Significant heterogeneity was observed in the 80+ group, which may be explained by methodological differences between studies. While males had a higher incidence of PD in all age groups, this difference was only statistically significant for those in the age range 60-69 and 70-79 (p < 0.05).

CONCLUSION

PD incidence generally increases with age, although it may stabilize in those who are 80+.

Authors+Show Affiliations

Department of Clinical Neurosciences, University of Calgary, Calgary, Alta., Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27105081

Citation

Hirsch, Lauren, et al. "The Incidence of Parkinson's Disease: a Systematic Review and Meta-Analysis." Neuroepidemiology, vol. 46, no. 4, 2016, pp. 292-300.
Hirsch L, Jette N, Frolkis A, et al. The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis. Neuroepidemiology. 2016;46(4):292-300.
Hirsch, L., Jette, N., Frolkis, A., Steeves, T., & Pringsheim, T. (2016). The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis. Neuroepidemiology, 46(4), 292-300. https://doi.org/10.1159/000445751
Hirsch L, et al. The Incidence of Parkinson's Disease: a Systematic Review and Meta-Analysis. Neuroepidemiology. 2016;46(4):292-300. PubMed PMID: 27105081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis. AU - Hirsch,Lauren, AU - Jette,Nathalie, AU - Frolkis,Alexandra, AU - Steeves,Thomas, AU - Pringsheim,Tamara, Y1 - 2016/04/23/ PY - 2015/09/22/received PY - 2016/03/11/accepted PY - 2016/4/23/entrez PY - 2016/4/23/pubmed PY - 2018/2/9/medline SP - 292 EP - 300 JF - Neuroepidemiology JO - Neuroepidemiology VL - 46 IS - 4 N2 - BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder. Epidemiological studies on the incidence of PD are important to better understand the risk factors for PD and determine the condition's natural history. OBJECTIVE: This systematic review and meta-analysis examine the incidence of PD and its variation by age and gender. METHODS: We searched MEDLINE and EMBASE for epidemiologic studies of PD from 2001 to 2014, as a previously published systematic review included studies published until 2001. Data were analyzed separately for age group and gender, and meta-regression was used to determine whether a significant difference was present between groups. RESULTS: Twenty-seven studies were included in the analysis. Meta-analysis of international studies showed rising incidence with age in both men and women. Significant heterogeneity was observed in the 80+ group, which may be explained by methodological differences between studies. While males had a higher incidence of PD in all age groups, this difference was only statistically significant for those in the age range 60-69 and 70-79 (p < 0.05). CONCLUSION: PD incidence generally increases with age, although it may stabilize in those who are 80+. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/27105081/The_Incidence_of_Parkinson's_Disease:_A_Systematic_Review_and_Meta_Analysis_ L2 - https://www.karger.com?DOI=10.1159/000445751 DB - PRIME DP - Unbound Medicine ER -