Tags

Type your tag names separated by a space and hit enter

Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis.

Abstract

Vitamin D may be involved in ocular function in older adults, but there is no current consensus on a possible association between circulating concentrations of 25-hydroxyvitamin D (25OHD) and the occurrence of age-related macular degeneration (AMD). Our objective was to systematically review and quantitatively assess the association of circulating 25OHD concentration with AMD. A Medline search was conducted in November 2015, with no date limit, using the MeSH terms "Vitamin D" OR "Vitamin D deficiency" OR "Ergocalciferols" OR 'Cholecalciferol' combined with "Age-related macular degeneration" OR "Macular degeneration" OR "Retinal degeneration" OR "Macula lutea" OR "Retina". Fixed and random-effects meta-analyses were performed to compute (i) standard mean difference in 25OHD concentration between AMD and non-AMD patients; (ii) AMD risk according to circulating 25OHD concentration. Of the 243 retrieved studies, 11 observational studies-10 cross-sectional studies and 1 cohort study-met the selection criteria. The number of participants ranged from 65 to 17,045 (52-100% women), and the number with AMD ranged from 31 to 1440. Circulating 25OHD concentration was 15% lower in AMD compared with non-AMD on average. AMD was inversely associated with the highest 25OHD quintile compared with the lowest (summary odds ratio (OR)=0.83 [95%CI:0.71-0.97]), notably late AMD (summary OR=0.47 [95%CI:0.28-0.79]). Circulating 25OHD<50nmol/L was also associated with late-stage AMD (summary OR=2.18 [95%CI:1.34-3.56]), an association that did not persist when all categories of AMD were considered (summary OR=1.26 [95%CI:0.90-1.76]). In conclusion, this meta-analysis provides evidence that high 25OHD concentrations may be protective against AMD, and that 25OHD concentrations below 50nmol/L are associated with late AMD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neuroscience, Division of Geriatric Medicine and Memory Clinic, Angers University Hospital, UPRES EA 4638, University of Angers, LUNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. Electronic address: CeAnnweiler@chu-angers.fr.

    ,

    Department of Neuroscience, Division of Ophthalmology, Angers University Hospital, Angers, France.

    ,

    Department of Neuroscience, Division of Geriatric Medicine and Memory Clinic, Angers University Hospital, UPRES EA 4638, University of Angers, LUNAM, Angers, France.

    ,

    Department of Neuroscience, Division of Geriatric Medicine and Memory Clinic, Angers University Hospital, UPRES EA 4638, University of Angers, LUNAM, Angers, France.

    ,

    Department of Neuroscience, Division of Ophthalmology, Angers University Hospital, Angers, France.

    ,

    Université d'Angers, Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS)-EA7315, LUNAM, Université d'Angers, Angers F-49000, France; Département de Médecine Physique et de Réadaptation, CHU, Angers F-49933, France.

    Department of Neuroscience, Division of Ophthalmology, Angers University Hospital, Angers, France; Singapore Eye Research Institute, Singapore, Singapore; Singapore National Eye Centre, Singapore, Singapore; Duke-NUS, Neuroscience and Behavioural Disorders, Singapore, Singapore.

    Source

    Maturitas 88: 2016 Jun pg 101-12

    MeSH

    Cross-Sectional Studies
    Humans
    Macular Degeneration
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    27105707

    Citation

    Annweiler, Cedric, et al. "Circulating Vitamin D Concentration and Age-related Macular Degeneration: Systematic Review and Meta-analysis." Maturitas, vol. 88, 2016, pp. 101-12.
    Annweiler C, Drouet M, Duval GT, et al. Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. Maturitas. 2016;88:101-12.
    Annweiler, C., Drouet, M., Duval, G. T., Paré, P. Y., Leruez, S., Dinomais, M., & Milea, D. (2016). Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. Maturitas, 88, pp. 101-12. doi:10.1016/j.maturitas.2016.04.002.
    Annweiler C, et al. Circulating Vitamin D Concentration and Age-related Macular Degeneration: Systematic Review and Meta-analysis. Maturitas. 2016;88:101-12. PubMed PMID: 27105707.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. AU - Annweiler,Cedric, AU - Drouet,Morgane, AU - Duval,Guillaume T, AU - Paré,Pierre-Yves, AU - Leruez,Stephanie, AU - Dinomais,Mickael, AU - Milea,Dan, Y1 - 2016/04/02/ PY - 2016/03/21/received PY - 2016/04/01/accepted PY - 2016/4/24/entrez PY - 2016/4/24/pubmed PY - 2017/5/5/medline KW - Age-related macular degeneration KW - Eye KW - Meta-analysis KW - Neuroendocrinology KW - Older adults KW - Vitamin D SP - 101 EP - 12 JF - Maturitas JO - Maturitas VL - 88 N2 - Vitamin D may be involved in ocular function in older adults, but there is no current consensus on a possible association between circulating concentrations of 25-hydroxyvitamin D (25OHD) and the occurrence of age-related macular degeneration (AMD). Our objective was to systematically review and quantitatively assess the association of circulating 25OHD concentration with AMD. A Medline search was conducted in November 2015, with no date limit, using the MeSH terms "Vitamin D" OR "Vitamin D deficiency" OR "Ergocalciferols" OR 'Cholecalciferol' combined with "Age-related macular degeneration" OR "Macular degeneration" OR "Retinal degeneration" OR "Macula lutea" OR "Retina". Fixed and random-effects meta-analyses were performed to compute (i) standard mean difference in 25OHD concentration between AMD and non-AMD patients; (ii) AMD risk according to circulating 25OHD concentration. Of the 243 retrieved studies, 11 observational studies-10 cross-sectional studies and 1 cohort study-met the selection criteria. The number of participants ranged from 65 to 17,045 (52-100% women), and the number with AMD ranged from 31 to 1440. Circulating 25OHD concentration was 15% lower in AMD compared with non-AMD on average. AMD was inversely associated with the highest 25OHD quintile compared with the lowest (summary odds ratio (OR)=0.83 [95%CI:0.71-0.97]), notably late AMD (summary OR=0.47 [95%CI:0.28-0.79]). Circulating 25OHD<50nmol/L was also associated with late-stage AMD (summary OR=2.18 [95%CI:1.34-3.56]), an association that did not persist when all categories of AMD were considered (summary OR=1.26 [95%CI:0.90-1.76]). In conclusion, this meta-analysis provides evidence that high 25OHD concentrations may be protective against AMD, and that 25OHD concentrations below 50nmol/L are associated with late AMD. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/27105707/Circulating_vitamin_D_concentration_and_age_related_macular_degeneration:_Systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(16)30072-X DB - PRIME DP - Unbound Medicine ER -