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Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis.
Maturitas 2016; 88:101-12M

Abstract

Vitamin D may be involved in ocular function in older adults, but there is no current consensus on a possible association between circulating concentrations of 25-hydroxyvitamin D (25OHD) and the occurrence of age-related macular degeneration (AMD). Our objective was to systematically review and quantitatively assess the association of circulating 25OHD concentration with AMD. A Medline search was conducted in November 2015, with no date limit, using the MeSH terms "Vitamin D" OR "Vitamin D deficiency" OR "Ergocalciferols" OR 'Cholecalciferol' combined with "Age-related macular degeneration" OR "Macular degeneration" OR "Retinal degeneration" OR "Macula lutea" OR "Retina". Fixed and random-effects meta-analyses were performed to compute (i) standard mean difference in 25OHD concentration between AMD and non-AMD patients; (ii) AMD risk according to circulating 25OHD concentration. Of the 243 retrieved studies, 11 observational studies-10 cross-sectional studies and 1 cohort study-met the selection criteria. The number of participants ranged from 65 to 17,045 (52-100% women), and the number with AMD ranged from 31 to 1440. Circulating 25OHD concentration was 15% lower in AMD compared with non-AMD on average. AMD was inversely associated with the highest 25OHD quintile compared with the lowest (summary odds ratio (OR)=0.83 [95%CI:0.71-0.97]), notably late AMD (summary OR=0.47 [95%CI:0.28-0.79]). Circulating 25OHD<50nmol/L was also associated with late-stage AMD (summary OR=2.18 [95%CI:1.34-3.56]), an association that did not persist when all categories of AMD were considered (summary OR=1.26 [95%CI:0.90-1.76]). In conclusion, this meta-analysis provides evidence that high 25OHD concentrations may be protective against AMD, and that 25OHD concentrations below 50nmol/L are associated with late AMD.

Authors+Show Affiliations

Department of Neuroscience, Division of Geriatric Medicine and Memory Clinic, Angers University Hospital, UPRES EA 4638, University of Angers, LUNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. Electronic address: CeAnnweiler@chu-angers.fr.Department of Neuroscience, Division of Ophthalmology, Angers University Hospital, Angers, France.Department of Neuroscience, Division of Geriatric Medicine and Memory Clinic, Angers University Hospital, UPRES EA 4638, University of Angers, LUNAM, Angers, France.Department of Neuroscience, Division of Geriatric Medicine and Memory Clinic, Angers University Hospital, UPRES EA 4638, University of Angers, LUNAM, Angers, France.Department of Neuroscience, Division of Ophthalmology, Angers University Hospital, Angers, France.Université d'Angers, Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS)-EA7315, LUNAM, Université d'Angers, Angers F-49000, France; Département de Médecine Physique et de Réadaptation, CHU, Angers F-49933, France.Department of Neuroscience, Division of Ophthalmology, Angers University Hospital, Angers, France; Singapore Eye Research Institute, Singapore, Singapore; Singapore National Eye Centre, Singapore, Singapore; Duke-NUS, Neuroscience and Behavioural Disorders, Singapore, Singapore.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27105707

Citation

Annweiler, Cedric, et al. "Circulating Vitamin D Concentration and Age-related Macular Degeneration: Systematic Review and Meta-analysis." Maturitas, vol. 88, 2016, pp. 101-12.
Annweiler C, Drouet M, Duval GT, et al. Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. Maturitas. 2016;88:101-12.
Annweiler, C., Drouet, M., Duval, G. T., Paré, P. Y., Leruez, S., Dinomais, M., & Milea, D. (2016). Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. Maturitas, 88, pp. 101-12. doi:10.1016/j.maturitas.2016.04.002.
Annweiler C, et al. Circulating Vitamin D Concentration and Age-related Macular Degeneration: Systematic Review and Meta-analysis. Maturitas. 2016;88:101-12. PubMed PMID: 27105707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. AU - Annweiler,Cedric, AU - Drouet,Morgane, AU - Duval,Guillaume T, AU - Paré,Pierre-Yves, AU - Leruez,Stephanie, AU - Dinomais,Mickael, AU - Milea,Dan, Y1 - 2016/04/02/ PY - 2016/03/21/received PY - 2016/04/01/accepted PY - 2016/4/24/entrez PY - 2016/4/24/pubmed PY - 2017/5/5/medline KW - Age-related macular degeneration KW - Eye KW - Meta-analysis KW - Neuroendocrinology KW - Older adults KW - Vitamin D SP - 101 EP - 12 JF - Maturitas JO - Maturitas VL - 88 N2 - Vitamin D may be involved in ocular function in older adults, but there is no current consensus on a possible association between circulating concentrations of 25-hydroxyvitamin D (25OHD) and the occurrence of age-related macular degeneration (AMD). Our objective was to systematically review and quantitatively assess the association of circulating 25OHD concentration with AMD. A Medline search was conducted in November 2015, with no date limit, using the MeSH terms "Vitamin D" OR "Vitamin D deficiency" OR "Ergocalciferols" OR 'Cholecalciferol' combined with "Age-related macular degeneration" OR "Macular degeneration" OR "Retinal degeneration" OR "Macula lutea" OR "Retina". Fixed and random-effects meta-analyses were performed to compute (i) standard mean difference in 25OHD concentration between AMD and non-AMD patients; (ii) AMD risk according to circulating 25OHD concentration. Of the 243 retrieved studies, 11 observational studies-10 cross-sectional studies and 1 cohort study-met the selection criteria. The number of participants ranged from 65 to 17,045 (52-100% women), and the number with AMD ranged from 31 to 1440. Circulating 25OHD concentration was 15% lower in AMD compared with non-AMD on average. AMD was inversely associated with the highest 25OHD quintile compared with the lowest (summary odds ratio (OR)=0.83 [95%CI:0.71-0.97]), notably late AMD (summary OR=0.47 [95%CI:0.28-0.79]). Circulating 25OHD<50nmol/L was also associated with late-stage AMD (summary OR=2.18 [95%CI:1.34-3.56]), an association that did not persist when all categories of AMD were considered (summary OR=1.26 [95%CI:0.90-1.76]). In conclusion, this meta-analysis provides evidence that high 25OHD concentrations may be protective against AMD, and that 25OHD concentrations below 50nmol/L are associated with late AMD. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/27105707/Circulating_vitamin_D_concentration_and_age_related_macular_degeneration:_Systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(16)30072-X DB - PRIME DP - Unbound Medicine ER -