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Protocol for systematic review and meta-analysis: hop (Humulus lupulus L.) for menopausal vasomotor symptoms.
BMJ Open. 2016 Apr 22; 6(4):e010734.BO

Abstract

INTRODUCTION

Menopause is a critical stage in every woman's life. It can cause a distressing time for women by creating various vasomotor symptoms (VMS). Phytoestrogens can potentially exert various favourable effects and alleviate VMS in postmenopausal women. The hop (Humulus lupulus L.) contains 8-prenylnaringenin (8-PN), the most potent phytoestrogen known to date. The hop is eight times stronger than any other herbal oestrogens. This study aims to conduct a comprehensive systematic review and a meta-analysis survey of the effects of hop in the management of VMS in postmenopausal women.

METHODS

Only randomised controlled clinical trials, with cluster randomisation and crossover, blinded and non-blinded designs, conducted between 2000 and 2015, will be included in this review. Quasi-experimental and observational studies as well as case reports will be excluded. The studies will be selected if their participants were aged 40-60 years, had elevated follicle-stimulating hormone (FSH) levels and/or menstrual irregularities, and experienced discomforting VMS (at least hot flashes or night sweats). The primary outcome will be the rate of response to treatment, such as changes in frequency and intensity of symptoms in the intervention and placebo groups. 'Hop', 'Humulus', 'menopause', 'vasomotor', 'hot flashes', 'phytoestrogen' and 'night sweats' will be used as search key words. Prior to their inclusion in the review, the selected papers will be assessed by two independent reviewers for methodological validity. Any disagreements will be resolved through a third reviewer. The risk of bias will be independently determined using the Cochrane Risk of Bias Tool. The quality of the papers will be assessed based on the CONSORT checklist.

ETHICS AND DISSEMINATION

Results will be disseminated through traditional academic literature. Dissemination of results will occur by peer-reviewed publications. The results of our project can help reproductive health researchers when evaluating the discomforts of research procedures described in study protocols or when designing a study. Information on experiences of menopausal women involved in previous studies may also help in future research. The expected dissemination actions are effective treatment in designing strategies that aim to develop women's health and healthcare providers when offering treatment for women with vasomotor symptoms.

Authors+Show Affiliations

Students' Research Office, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Midwifery and Reproductive Health, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

27105715

Citation

Abdi, Fatemeh, et al. "Protocol for Systematic Review and Meta-analysis: Hop (Humulus Lupulus L.) for Menopausal Vasomotor Symptoms." BMJ Open, vol. 6, no. 4, 2016, pp. e010734.
Abdi F, Kazemi F, Ramezani Tehrani F, et al. Protocol for systematic review and meta-analysis: hop (Humulus lupulus L.) for menopausal vasomotor symptoms. BMJ Open. 2016;6(4):e010734.
Abdi, F., Kazemi, F., Ramezani Tehrani, F., & Roozbeh, N. (2016). Protocol for systematic review and meta-analysis: hop (Humulus lupulus L.) for menopausal vasomotor symptoms. BMJ Open, 6(4), e010734. https://doi.org/10.1136/bmjopen-2015-010734
Abdi F, et al. Protocol for Systematic Review and Meta-analysis: Hop (Humulus Lupulus L.) for Menopausal Vasomotor Symptoms. BMJ Open. 2016 Apr 22;6(4):e010734. PubMed PMID: 27105715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protocol for systematic review and meta-analysis: hop (Humulus lupulus L.) for menopausal vasomotor symptoms. AU - Abdi,Fatemeh, AU - Kazemi,Farideh, AU - Ramezani Tehrani,Fahimeh, AU - Roozbeh,Nasibeh, Y1 - 2016/04/22/ PY - 2016/4/24/entrez PY - 2016/4/24/pubmed PY - 2017/1/4/medline SP - e010734 EP - e010734 JF - BMJ open JO - BMJ Open VL - 6 IS - 4 N2 - INTRODUCTION: Menopause is a critical stage in every woman's life. It can cause a distressing time for women by creating various vasomotor symptoms (VMS). Phytoestrogens can potentially exert various favourable effects and alleviate VMS in postmenopausal women. The hop (Humulus lupulus L.) contains 8-prenylnaringenin (8-PN), the most potent phytoestrogen known to date. The hop is eight times stronger than any other herbal oestrogens. This study aims to conduct a comprehensive systematic review and a meta-analysis survey of the effects of hop in the management of VMS in postmenopausal women. METHODS: Only randomised controlled clinical trials, with cluster randomisation and crossover, blinded and non-blinded designs, conducted between 2000 and 2015, will be included in this review. Quasi-experimental and observational studies as well as case reports will be excluded. The studies will be selected if their participants were aged 40-60 years, had elevated follicle-stimulating hormone (FSH) levels and/or menstrual irregularities, and experienced discomforting VMS (at least hot flashes or night sweats). The primary outcome will be the rate of response to treatment, such as changes in frequency and intensity of symptoms in the intervention and placebo groups. 'Hop', 'Humulus', 'menopause', 'vasomotor', 'hot flashes', 'phytoestrogen' and 'night sweats' will be used as search key words. Prior to their inclusion in the review, the selected papers will be assessed by two independent reviewers for methodological validity. Any disagreements will be resolved through a third reviewer. The risk of bias will be independently determined using the Cochrane Risk of Bias Tool. The quality of the papers will be assessed based on the CONSORT checklist. ETHICS AND DISSEMINATION: Results will be disseminated through traditional academic literature. Dissemination of results will occur by peer-reviewed publications. The results of our project can help reproductive health researchers when evaluating the discomforts of research procedures described in study protocols or when designing a study. Information on experiences of menopausal women involved in previous studies may also help in future research. The expected dissemination actions are effective treatment in designing strategies that aim to develop women's health and healthcare providers when offering treatment for women with vasomotor symptoms. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/27105715/Protocol_for_systematic_review_and_meta_analysis:_hop__Humulus_lupulus_L___for_menopausal_vasomotor_symptoms_ DB - PRIME DP - Unbound Medicine ER -