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The effect of a vegetarian versus conventional hypocaloric diet on serum concentrations of persistent organic pollutants in patients with type 2 diabetes.
Nutr Metab Cardiovasc Dis 2016; 26(5):430-8NM

Abstract

BACKGROUND AND AIMS

The aim of this study was to explore the effect of a vegetarian versus conventional diet on the serum levels of persistent organic pollutants (POPs) in patients with T2D after 12 weeks of dietary intervention and to assess their relationships with metabolic parameters.

METHODS AND RESULTS

Men and women with T2D were randomly assigned to follow either a vegetarian diet without fish or meat (n = 37) or an isocaloric conventional antidiabetic diet (n = 37). Both diets were energy restricted (minus 500 kcal/day). All foods were provided to the participants. At randomization (week 0) and 12 weeks, the meal test was performed to assess the β-cell function and serum levels of 24 POPs. Dioxins and dioxin-like POPs were analyzed by isotope dilution high-resolution gas chromatography (HRGC) and mass spectrometry after cleanup of the silica and carbon columns. Non-dioxin-like POPs were analyzed by gas chromatography with an electron capture detector (GC-ECD). Statistical analyses used were repeated-measures analysis of variance (ANOVA), a multivariate regression model, and Pearson's correlations. We observed a statistically nonsignificant trend toward increases in the serum levels of most POPs in response to both hypocaloric diets with no differences between groups. In the groups combined, the change in serum concentrations of total POPs was correlated to changes in HbA1c (r = +0.34; p < 0.01), fasting plasma glucose (r = +0.41; p < 0.01) levels, and β-cell function measured as insulin secretion at a reference glucose level (r = -0.37; p < 0.01), independent of the changes in body weight and volume of visceral fat.

CONCLUSION

Short-term hypocaloric vegetarian and conventional diets did not reduce the POP levels, possibly due to mobilization of fat stores. Our findings support the relationship between POPs and diabetes, especially β-cell function.

TRIAL REGISTRATION

ClinicalTrials.gov number, NCT00883038, completed.

Authors+Show Affiliations

Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic. Electronic address: hana.kahleova@gmail.com.Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.State Veterinary Institute Prague, Sidlistni 24, 165 03 Prague, Czech Republic.State Veterinary Institute Prague, Sidlistni 24, 165 03 Prague, Czech Republic.C.N.R. (National Research Council) Institute of Systems Science and Biomedical Engineering, Padua, Italy.Institute of Endocrinology, Narodni 8, 11394 Prague, Czech Republic.Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27107842

Citation

Kahleova, H, et al. "The Effect of a Vegetarian Versus Conventional Hypocaloric Diet On Serum Concentrations of Persistent Organic Pollutants in Patients With Type 2 Diabetes." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 26, no. 5, 2016, pp. 430-8.
Kahleova H, Tonstad S, Rosmus J, et al. The effect of a vegetarian versus conventional hypocaloric diet on serum concentrations of persistent organic pollutants in patients with type 2 diabetes. Nutr Metab Cardiovasc Dis. 2016;26(5):430-8.
Kahleova, H., Tonstad, S., Rosmus, J., Fisar, P., Mari, A., Hill, M., & Pelikanova, T. (2016). The effect of a vegetarian versus conventional hypocaloric diet on serum concentrations of persistent organic pollutants in patients with type 2 diabetes. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 26(5), pp. 430-8. doi:10.1016/j.numecd.2016.01.008.
Kahleova H, et al. The Effect of a Vegetarian Versus Conventional Hypocaloric Diet On Serum Concentrations of Persistent Organic Pollutants in Patients With Type 2 Diabetes. Nutr Metab Cardiovasc Dis. 2016;26(5):430-8. PubMed PMID: 27107842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of a vegetarian versus conventional hypocaloric diet on serum concentrations of persistent organic pollutants in patients with type 2 diabetes. AU - Kahleova,H, AU - Tonstad,S, AU - Rosmus,J, AU - Fisar,P, AU - Mari,A, AU - Hill,M, AU - Pelikanova,T, Y1 - 2016/01/28/ PY - 2015/10/01/received PY - 2015/12/18/revised PY - 2016/01/21/accepted PY - 2016/4/25/entrez PY - 2016/4/25/pubmed PY - 2017/8/2/medline KW - Persistent organic pollutants KW - Type 2 diabetes KW - Vegetarian diet SP - 430 EP - 8 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 26 IS - 5 N2 - BACKGROUND AND AIMS: The aim of this study was to explore the effect of a vegetarian versus conventional diet on the serum levels of persistent organic pollutants (POPs) in patients with T2D after 12 weeks of dietary intervention and to assess their relationships with metabolic parameters. METHODS AND RESULTS: Men and women with T2D were randomly assigned to follow either a vegetarian diet without fish or meat (n = 37) or an isocaloric conventional antidiabetic diet (n = 37). Both diets were energy restricted (minus 500 kcal/day). All foods were provided to the participants. At randomization (week 0) and 12 weeks, the meal test was performed to assess the β-cell function and serum levels of 24 POPs. Dioxins and dioxin-like POPs were analyzed by isotope dilution high-resolution gas chromatography (HRGC) and mass spectrometry after cleanup of the silica and carbon columns. Non-dioxin-like POPs were analyzed by gas chromatography with an electron capture detector (GC-ECD). Statistical analyses used were repeated-measures analysis of variance (ANOVA), a multivariate regression model, and Pearson's correlations. We observed a statistically nonsignificant trend toward increases in the serum levels of most POPs in response to both hypocaloric diets with no differences between groups. In the groups combined, the change in serum concentrations of total POPs was correlated to changes in HbA1c (r = +0.34; p < 0.01), fasting plasma glucose (r = +0.41; p < 0.01) levels, and β-cell function measured as insulin secretion at a reference glucose level (r = -0.37; p < 0.01), independent of the changes in body weight and volume of visceral fat. CONCLUSION: Short-term hypocaloric vegetarian and conventional diets did not reduce the POP levels, possibly due to mobilization of fat stores. Our findings support the relationship between POPs and diabetes, especially β-cell function. TRIAL REGISTRATION: ClinicalTrials.gov number, NCT00883038, completed. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/27107842/The_effect_of_a_vegetarian_versus_conventional_hypocaloric_diet_on_serum_concentrations_of_persistent_organic_pollutants_in_patients_with_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(15)30248-9 DB - PRIME DP - Unbound Medicine ER -