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Relationship between grey matter integrity and executive abilities in aging.
Brain Res 2016; 1642:562-580BR

Abstract

This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18-30 years old) and 43 seniors (60-75 years old) were included. A general executive score was derived from a large battery of neuropsychological tests assessing three major aspects of executive functioning (inhibition, updating and shifting). Age-related grey matter changes were investigated by comparing young and older adults using voxel-based morphometry and voxel-based cortical thickness methods. A widespread difference in grey matter volume was found across many brain regions, whereas cortical thinning was mainly restricted to central areas. Multivariate analyses showed age-related changes in relatively similar brain regions to the respective univariate analyses but appeared more limited. Finally, in the older adult sample, a significant relationship between global executive performance and decreased grey matter volume in anterior (i.e. frontal, insular and cingulate cortex) but also some posterior brain areas (i.e. temporal and parietal cortices) as well as subcortical structures was observed. Results of this study highlight the distribution of age-related effects on grey matter volume and show that cortical atrophy does not appear primarily in "frontal" brain regions. From a cognitive viewpoint, age-related executive functioning seems to be related to grey matter volume but not to cortical thickness. Therefore, our results also highlight the influence of methodological aspects (from preprocessing to statistical analysis) on the pattern of results, which could explain the lack of consensus in literature.

Authors+Show Affiliations

GIGA-Cyclotron Research Centre: In vivo Imaging, University of Liège, Allée du 6 Ao슩t 8, Bât B30, B-4000 Liège, Belgium; Psychology and Neuroscience of Cognition Research Unit, University of Liège, Boulevard du Rectorat 3, Bât B33, B-4000 Liège, Belgium.GIGA-Cyclotron Research Centre: In vivo Imaging, University of Liège, Allée du 6 Ao슩t 8, Bât B30, B-4000 Liège, Belgium.GIGA-Cyclotron Research Centre: In vivo Imaging, University of Liège, Allée du 6 Ao슩t 8, Bât B30, B-4000 Liège, Belgium.GIGA-Cyclotron Research Centre: In vivo Imaging, University of Liège, Allée du 6 Ao슩t 8, Bât B30, B-4000 Liège, Belgium; Psychology and Neuroscience of Cognition Research Unit, University of Liège, Boulevard du Rectorat 3, Bât B33, B-4000 Liège, Belgium. Electronic address: f.collette@ulg.ac.be.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27107940

Citation

Manard, Marine, et al. "Relationship Between Grey Matter Integrity and Executive Abilities in Aging." Brain Research, vol. 1642, 2016, pp. 562-580.
Manard M, Bahri MA, Salmon E, et al. Relationship between grey matter integrity and executive abilities in aging. Brain Res. 2016;1642:562-580.
Manard, M., Bahri, M. A., Salmon, E., & Collette, F. (2016). Relationship between grey matter integrity and executive abilities in aging. Brain Research, 1642, pp. 562-580. doi:10.1016/j.brainres.2016.04.045.
Manard M, et al. Relationship Between Grey Matter Integrity and Executive Abilities in Aging. Brain Res. 2016 07 1;1642:562-580. PubMed PMID: 27107940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between grey matter integrity and executive abilities in aging. AU - Manard,Marine, AU - Bahri,Mohamed Ali, AU - Salmon,Eric, AU - Collette,Fabienne, Y1 - 2016/04/20/ PY - 2015/12/14/received PY - 2016/04/05/revised PY - 2016/04/19/accepted PY - 2016/4/25/entrez PY - 2016/4/25/pubmed PY - 2017/6/29/medline KW - Aging KW - Cerebral cortex KW - Cross-sectional KW - Executive functioning KW - Grey matter KW - Multivariate analysis SP - 562 EP - 580 JF - Brain research JO - Brain Res. VL - 1642 N2 - This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18-30 years old) and 43 seniors (60-75 years old) were included. A general executive score was derived from a large battery of neuropsychological tests assessing three major aspects of executive functioning (inhibition, updating and shifting). Age-related grey matter changes were investigated by comparing young and older adults using voxel-based morphometry and voxel-based cortical thickness methods. A widespread difference in grey matter volume was found across many brain regions, whereas cortical thinning was mainly restricted to central areas. Multivariate analyses showed age-related changes in relatively similar brain regions to the respective univariate analyses but appeared more limited. Finally, in the older adult sample, a significant relationship between global executive performance and decreased grey matter volume in anterior (i.e. frontal, insular and cingulate cortex) but also some posterior brain areas (i.e. temporal and parietal cortices) as well as subcortical structures was observed. Results of this study highlight the distribution of age-related effects on grey matter volume and show that cortical atrophy does not appear primarily in "frontal" brain regions. From a cognitive viewpoint, age-related executive functioning seems to be related to grey matter volume but not to cortical thickness. Therefore, our results also highlight the influence of methodological aspects (from preprocessing to statistical analysis) on the pattern of results, which could explain the lack of consensus in literature. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/27107940/Relationship_between_grey_matter_integrity_and_executive_abilities_in_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(16)30265-7 DB - PRIME DP - Unbound Medicine ER -