Tags

Type your tag names separated by a space and hit enter

The role of thromboxane A2 (TxA2) in allergic cutaneous reactions and the effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) phenyl]-2-propenoic acid hydrochloride (OKY-046), a TxA2 synthetase inhibitor.
Prostaglandins Leukot Essent Fatty Acids. 1989 Mar; 35(3):125-30.PL

Abstract

To study the role of thromboxane A2 (TxA2) in cutaneous allergic reactions, the effect of (E)-3-[p-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride (OKY-046), a selective TxA2 synthetase inhibitor, on cutaneous reactions in rats and mice was studied. Simultaneously, the effect of 9,11-methanoepoxy-prostaglandin H2 (U-46619), a stable analogue of TxA2, on capillary permeability in mouse and rat skin was investigated. Passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by OKY-046 but not by indomethacin. The inhibitory action of OKY-046 was not influenced by pretreatment with indomethacin. Moreover, prostaglandin I2, which accumulated as a result of the inhibition of TxA2 synthetase, did not affect the PCA. But, the dye leakages caused by histamine, serotonin and leukotriene C4 in mouse ear were clearly inhibited by OKY-046. In addition, OKY-046 inhibited rat reversed cutaneous anaphylaxis, but its inhibitory action was not affected by pretreatment with indomethacin. Contrary to the above results, rat footpad passive Arthus reaction and mouse footpad tuberculin delayed hypersensitivity reaction were not affected by OKY-046. Additionally, U-46619 did not cause an increase of capillary permeability in either mouse and rat skin. These results suggest a slight role of TxA2 in cutaneous allergic reactions in mice and rats and the efficacy of OKY-046 on Type I and II reactions regardless of the inhibition of TxA2 synthetase activity.

Authors+Show Affiliations

Department of Pharmacology, Gifu Pharmaceutical University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2710796

Citation

Nagai, H, et al. "The Role of Thromboxane A2 (TxA2) in Allergic Cutaneous Reactions and the Effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) Phenyl]-2-propenoic Acid Hydrochloride (OKY-046), a TxA2 Synthetase Inhibitor." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 35, no. 3, 1989, pp. 125-30.
Nagai H, Yakuo I, Nakatomi I, et al. The role of thromboxane A2 (TxA2) in allergic cutaneous reactions and the effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) phenyl]-2-propenoic acid hydrochloride (OKY-046), a TxA2 synthetase inhibitor. Prostaglandins Leukot Essent Fatty Acids. 1989;35(3):125-30.
Nagai, H., Yakuo, I., Nakatomi, I., Inagaki, N., & Koda, A. (1989). The role of thromboxane A2 (TxA2) in allergic cutaneous reactions and the effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) phenyl]-2-propenoic acid hydrochloride (OKY-046), a TxA2 synthetase inhibitor. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 35(3), 125-30.
Nagai H, et al. The Role of Thromboxane A2 (TxA2) in Allergic Cutaneous Reactions and the Effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) Phenyl]-2-propenoic Acid Hydrochloride (OKY-046), a TxA2 Synthetase Inhibitor. Prostaglandins Leukot Essent Fatty Acids. 1989;35(3):125-30. PubMed PMID: 2710796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of thromboxane A2 (TxA2) in allergic cutaneous reactions and the effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) phenyl]-2-propenoic acid hydrochloride (OKY-046), a TxA2 synthetase inhibitor. AU - Nagai,H, AU - Yakuo,I, AU - Nakatomi,I, AU - Inagaki,N, AU - Koda,A, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 125 EP - 30 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 35 IS - 3 N2 - To study the role of thromboxane A2 (TxA2) in cutaneous allergic reactions, the effect of (E)-3-[p-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride (OKY-046), a selective TxA2 synthetase inhibitor, on cutaneous reactions in rats and mice was studied. Simultaneously, the effect of 9,11-methanoepoxy-prostaglandin H2 (U-46619), a stable analogue of TxA2, on capillary permeability in mouse and rat skin was investigated. Passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by OKY-046 but not by indomethacin. The inhibitory action of OKY-046 was not influenced by pretreatment with indomethacin. Moreover, prostaglandin I2, which accumulated as a result of the inhibition of TxA2 synthetase, did not affect the PCA. But, the dye leakages caused by histamine, serotonin and leukotriene C4 in mouse ear were clearly inhibited by OKY-046. In addition, OKY-046 inhibited rat reversed cutaneous anaphylaxis, but its inhibitory action was not affected by pretreatment with indomethacin. Contrary to the above results, rat footpad passive Arthus reaction and mouse footpad tuberculin delayed hypersensitivity reaction were not affected by OKY-046. Additionally, U-46619 did not cause an increase of capillary permeability in either mouse and rat skin. These results suggest a slight role of TxA2 in cutaneous allergic reactions in mice and rats and the efficacy of OKY-046 on Type I and II reactions regardless of the inhibition of TxA2 synthetase activity. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/2710796/The_role_of_thromboxane_A2__TxA2__in_allergic_cutaneous_reactions_and_the_effect_of__E__3_[p__1H_imidazol_1_ylmethyl__phenyl]_2_propenoic_acid_hydrochloride__OKY_046__a_TxA2_synthetase_inhibitor_ DB - PRIME DP - Unbound Medicine ER -