Tags

Type your tag names separated by a space and hit enter

The antioxidative property of melatonin against brain ischemia.
Expert Rev Neurother. 2016 07; 16(7):841-8.ER

Abstract

INTRODUCTION

This review briefly summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ tissue damage in neural ischemia-reperfusion injury (stroke), where free radicals are generally considered as being responsible for much of the resulting tissue destruction.

AREA COVERED

Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several of its metabolites such as N(1)-acetyl-N(2)-formyl-5- methoxykynuramine (AFMK) and N(1)-acetyl-5-methoxykynuramine (AMF), are themselves scavengers suggesting that there is a cascade of reactions that greatly increase the efficacy of melatonin. Expert Commentary: However, the mechanisms by which melatonin is protective in such widely diverse areas of the cell and different organs are likely not yet all identified.

Authors+Show Affiliations

a Department of Biological and Environmental Sciences , University of Messina , Messina , Italy.a Department of Biological and Environmental Sciences , University of Messina , Messina , Italy.a Department of Biological and Environmental Sciences , University of Messina , Messina , Italy.a Department of Biological and Environmental Sciences , University of Messina , Messina , Italy. b Department of Pharmacological and Physiological Science , Saint Louis University School of Medicine , St. Louis , MO , USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27108742

Citation

Paterniti, Irene, et al. "The Antioxidative Property of Melatonin Against Brain Ischemia." Expert Review of Neurotherapeutics, vol. 16, no. 7, 2016, pp. 841-8.
Paterniti I, Cordaro M, Esposito E, et al. The antioxidative property of melatonin against brain ischemia. Expert Rev Neurother. 2016;16(7):841-8.
Paterniti, I., Cordaro, M., Esposito, E., & Cuzzocrea, S. (2016). The antioxidative property of melatonin against brain ischemia. Expert Review of Neurotherapeutics, 16(7), 841-8. https://doi.org/10.1080/14737175.2016.1182020
Paterniti I, et al. The Antioxidative Property of Melatonin Against Brain Ischemia. Expert Rev Neurother. 2016;16(7):841-8. PubMed PMID: 27108742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The antioxidative property of melatonin against brain ischemia. AU - Paterniti,Irene, AU - Cordaro,Marika, AU - Esposito,Emanuela, AU - Cuzzocrea,Salvatore, Y1 - 2016/05/09/ PY - 2016/4/26/entrez PY - 2016/4/26/pubmed PY - 2017/6/9/medline KW - Melatonin KW - antioxidant KW - free radicals KW - ischemia-reperfusion injury KW - oxidative stress SP - 841 EP - 8 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 16 IS - 7 N2 - INTRODUCTION: This review briefly summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ tissue damage in neural ischemia-reperfusion injury (stroke), where free radicals are generally considered as being responsible for much of the resulting tissue destruction. AREA COVERED: Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several of its metabolites such as N(1)-acetyl-N(2)-formyl-5- methoxykynuramine (AFMK) and N(1)-acetyl-5-methoxykynuramine (AMF), are themselves scavengers suggesting that there is a cascade of reactions that greatly increase the efficacy of melatonin. Expert Commentary: However, the mechanisms by which melatonin is protective in such widely diverse areas of the cell and different organs are likely not yet all identified. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/27108742/The_antioxidative_property_of_melatonin_against_brain_ischemia_ L2 - https://www.tandfonline.com/doi/full/10.1080/14737175.2016.1182020 DB - PRIME DP - Unbound Medicine ER -