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The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: A Systematic Meta-Analytic Review.
Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(4):2168-77.IO

Abstract

PURPOSE

We conducted a meta-analysis of individual studies reporting an association between serum vitamin D levels and AMD.

METHODS

Relevant studies evaluating the association between serum vitamin D levels and AMD risk were identified by systematically searching four electronic literature databases (Ovid Medline, PubMed, EMBASE, and ISI Web of Science) censored by June 2015. Due to the heterogeneity of studies in categorizing serum vitamin D levels, all individual odds ratios (ORs) were recalculated and transferred for an increase of serum vitamin D levels by 10 ng/ml. Summary ORs and 95% confidence intervals (CIs) of AMD risk per 10-unit increase of serum vitamin D were obtained using standard meta-analysis. Publication bias was evaluated using funnel plots and Kendall's rank correlation tests.

RESULTS

Ten individual studies were included and pooled in this meta-analysis. Meta-analysis of studies on AMD risk led to a pooled OR (95% CI) of 0.91 (0.69-1.22) for an increase of 25-hydroxy vitamin D by 10 ng/mL (P = 0.12). No indication for publication bias was found, but substantial heterogeneity was obtained (I2 = 79.7%, P < 0.01). Estimates from subgroup analyses also did not show statistically significant associations of serum vitamin D levels with different stages (early AMD, late AMD, and advanced AMD) and subtypes of AMD (neovascular AMD and nonneovascular AMD; P > 0.05).

CONCLUSIONS

There is no evidence to indicate an inverse association between serum vitamin D levels and any stages and subtypes of AMD risk, but opposite results from the United States and Korea resulted in this nonsignificance. Potential difference across various study designs might exist, based on few studies reporting in heterogeneous manners so far. More studies are needed to further confirm the causality of vitamin D and AMD, especially longitudinal studies.

Authors+Show Affiliations

Eye Center Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China 2Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang, China.Eye Center Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China 2Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang, China.Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

27111565

Citation

Wu, Wei, et al. "The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: a Systematic Meta-Analytic Review." Investigative Ophthalmology & Visual Science, vol. 57, no. 4, 2016, pp. 2168-77.
Wu W, Weng Y, Guo X, et al. The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: A Systematic Meta-Analytic Review. Invest Ophthalmol Vis Sci. 2016;57(4):2168-77.
Wu, W., Weng, Y., Guo, X., Feng, L., Xia, H., Jiang, Z., & Lou, J. (2016). The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: A Systematic Meta-Analytic Review. Investigative Ophthalmology & Visual Science, 57(4), 2168-77. https://doi.org/10.1167/iovs.15-18218
Wu W, et al. The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: a Systematic Meta-Analytic Review. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2168-77. PubMed PMID: 27111565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: A Systematic Meta-Analytic Review. AU - Wu,Wei, AU - Weng,Yan, AU - Guo,Xinnian, AU - Feng,Lingfang, AU - Xia,Hailing, AU - Jiang,Zhaoqiang, AU - Lou,Jianlin, PY - 2016/4/26/entrez PY - 2016/4/26/pubmed PY - 2016/9/3/medline SP - 2168 EP - 77 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 57 IS - 4 N2 - PURPOSE: We conducted a meta-analysis of individual studies reporting an association between serum vitamin D levels and AMD. METHODS: Relevant studies evaluating the association between serum vitamin D levels and AMD risk were identified by systematically searching four electronic literature databases (Ovid Medline, PubMed, EMBASE, and ISI Web of Science) censored by June 2015. Due to the heterogeneity of studies in categorizing serum vitamin D levels, all individual odds ratios (ORs) were recalculated and transferred for an increase of serum vitamin D levels by 10 ng/ml. Summary ORs and 95% confidence intervals (CIs) of AMD risk per 10-unit increase of serum vitamin D were obtained using standard meta-analysis. Publication bias was evaluated using funnel plots and Kendall's rank correlation tests. RESULTS: Ten individual studies were included and pooled in this meta-analysis. Meta-analysis of studies on AMD risk led to a pooled OR (95% CI) of 0.91 (0.69-1.22) for an increase of 25-hydroxy vitamin D by 10 ng/mL (P = 0.12). No indication for publication bias was found, but substantial heterogeneity was obtained (I2 = 79.7%, P < 0.01). Estimates from subgroup analyses also did not show statistically significant associations of serum vitamin D levels with different stages (early AMD, late AMD, and advanced AMD) and subtypes of AMD (neovascular AMD and nonneovascular AMD; P > 0.05). CONCLUSIONS: There is no evidence to indicate an inverse association between serum vitamin D levels and any stages and subtypes of AMD risk, but opposite results from the United States and Korea resulted in this nonsignificance. Potential difference across various study designs might exist, based on few studies reporting in heterogeneous manners so far. More studies are needed to further confirm the causality of vitamin D and AMD, especially longitudinal studies. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/27111565/The_Association_Between_Serum_Vitamin_D_Levels_and_Age_Related_Macular_Degeneration:_A_Systematic_Meta_Analytic_Review_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.15-18218 DB - PRIME DP - Unbound Medicine ER -