Tags

Type your tag names separated by a space and hit enter

Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake.
J Neuroendocrinol. 2016 04; 28(4)JN

Abstract

Central oxytocin (OT) promotes feeding termination in response to homeostatic challenges, such as excessive stomach distension, salt loading and toxicity. OT has also been proposed to affect feeding reward by decreasing the consumption of palatable carbohydrates and sweet tastants. Because the OT receptor (OTR) is expressed in the nucleus accumbens core (AcbC) and shell (AcbSh), a site regulating diverse aspects of eating behaviour, we investigated whether OT acts there to affect appetite in rats. First, we examined whether direct AcbC and AcbSh OT injections affect hunger- and palatability-driven consumption. We found that only AcbC OT infusions decrease deprivation-induced chow intake and reduce the consumption of palatable sucrose and saccharin solutions in nondeprived animals. These effects were abolished by pretreatment with an OTR antagonist, L-368,899, injected in the same site. AcbC OT at an anorexigenic dose did not induce a conditioned taste aversion, which indicates that AcbC OT-driven anorexia is not caused by sickness/malaise. The appetite-specific effect of AcbC OT is supported by the real-time polymerase chain reaction analysis of OTR mRNA in the AcbC, which revealed that food deprivation elevates OTR mRNA expression, whereas saccharin solution intake decreases OTR transcript levels. We also used c-Fos immunohistochemistry as a marker of neuronal activation and found that AcbC OT injection increases activation of the AcbC itself, as well as of two feeding-related sites: the hypothalamic paraventricular and supraoptic nuclei. Finally, considering the fact that OT plays a significant role in social behaviour, we examined whether offering animals a meal in a social setting would modify their hypophagic response to AcbC OT injections. We found that a social context abolishes the anorexigenic effects of AcbC OT. We conclude that OT acting via the AcbC decreases food intake driven by hunger and reward in rats offered a meal in a nonsocial setting.

Authors+Show Affiliations

Department of Biological Sciences, Faculty of Science and Engineering, University of Waikato, Hamilton, New Zealand.Department of Biological Sciences, Faculty of Science and Engineering, University of Waikato, Hamilton, New Zealand.Department of Neuroscience, Uppsala University, Uppsala, Sweden.Department of Neuroscience, Uppsala University, Uppsala, Sweden.Department of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA.Department of Biological Sciences, Faculty of Science and Engineering, University of Waikato, Hamilton, New Zealand. Department of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27114001

Citation

Herisson, F M., et al. "Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake." Journal of Neuroendocrinology, vol. 28, no. 4, 2016.
Herisson FM, Waas JR, Fredriksson R, et al. Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake. J Neuroendocrinol. 2016;28(4).
Herisson, F. M., Waas, J. R., Fredriksson, R., Schiöth, H. B., Levine, A. S., & Olszewski, P. K. (2016). Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake. Journal of Neuroendocrinology, 28(4). https://doi.org/10.1111/jne.12381
Herisson FM, et al. Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake. J Neuroendocrinol. 2016;28(4) PubMed PMID: 27114001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake. AU - Herisson,F M, AU - Waas,J R, AU - Fredriksson,R, AU - Schiöth,H B, AU - Levine,A S, AU - Olszewski,P K, PY - 2015/08/27/received PY - 2016/01/29/revised PY - 2016/02/24/accepted PY - 2016/4/27/entrez PY - 2016/4/27/pubmed PY - 2018/2/9/medline KW - food intake KW - hunger KW - oxytocin KW - reward KW - satiety JF - Journal of neuroendocrinology JO - J Neuroendocrinol VL - 28 IS - 4 N2 - Central oxytocin (OT) promotes feeding termination in response to homeostatic challenges, such as excessive stomach distension, salt loading and toxicity. OT has also been proposed to affect feeding reward by decreasing the consumption of palatable carbohydrates and sweet tastants. Because the OT receptor (OTR) is expressed in the nucleus accumbens core (AcbC) and shell (AcbSh), a site regulating diverse aspects of eating behaviour, we investigated whether OT acts there to affect appetite in rats. First, we examined whether direct AcbC and AcbSh OT injections affect hunger- and palatability-driven consumption. We found that only AcbC OT infusions decrease deprivation-induced chow intake and reduce the consumption of palatable sucrose and saccharin solutions in nondeprived animals. These effects were abolished by pretreatment with an OTR antagonist, L-368,899, injected in the same site. AcbC OT at an anorexigenic dose did not induce a conditioned taste aversion, which indicates that AcbC OT-driven anorexia is not caused by sickness/malaise. The appetite-specific effect of AcbC OT is supported by the real-time polymerase chain reaction analysis of OTR mRNA in the AcbC, which revealed that food deprivation elevates OTR mRNA expression, whereas saccharin solution intake decreases OTR transcript levels. We also used c-Fos immunohistochemistry as a marker of neuronal activation and found that AcbC OT injection increases activation of the AcbC itself, as well as of two feeding-related sites: the hypothalamic paraventricular and supraoptic nuclei. Finally, considering the fact that OT plays a significant role in social behaviour, we examined whether offering animals a meal in a social setting would modify their hypophagic response to AcbC OT injections. We found that a social context abolishes the anorexigenic effects of AcbC OT. We conclude that OT acting via the AcbC decreases food intake driven by hunger and reward in rats offered a meal in a nonsocial setting. SN - 1365-2826 UR - https://www.unboundmedicine.com/medline/citation/27114001/Oxytocin_Acting_in_the_Nucleus_Accumbens_Core_Decreases_Food_Intake_ L2 - https://doi.org/10.1111/jne.12381 DB - PRIME DP - Unbound Medicine ER -