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Evaluation of white matter integrity in systemic lupus erythematosus by diffusion tensor magnetic resonance imaging: a study using tract-based spatial statistics.
Neuroradiology. 2016 Aug; 58(8):819-25.N

Abstract

INTRODUCTION

The aim of this study was to evaluate the white matter integrity in brains of patients with systemic lupus erythematosus (SLE) using a voxel-based analyses of diffusion tensor imaging (DTI) data.

METHODS

Fifty-seven patients with SLE were compared to 36 control patients who were matched by gender, age, education, and Mini Mental State Examination score. DTI was performed along 30 noncollinear directions in a 1.5 Tesla scanner. For tract-based spatial statistics (TBSS), a white matter skeleton was created, and a permutation-based inference with 5000 permutations and a threshold of p < 0.05 was used to identify abnormalities in fractional anisotropy (FA). The mean (MD), radial (RD), and axial diffusivities (AD) were also projected onto the mean FA skeleton.

RESULTS

We found a significant decrease of global FA in SLE patients compared to controls. The areas of reduced FA included the right superior corona radiata, the right superior longitudinal fasciculus, the body of the corpus callosum, the right inferior fronto-occipital fasciculus, the right thalamic radiation, and the right uncinate fasciculus. Patients with SLE also had increased AD and RD in several areas. Substantial overlap of areas with increased AD and RD occurred and were spatially much more extensive than the areas of reduced FA.

CONCLUSION

Significant increases of AD values were concordant to those of RD and MD and more extensive than FA changes. Analyzing all diffusivity parameters, using TBSS, can detect more white matter microstructural changes in patients with SLE than analyzing FA alone.

Authors+Show Affiliations

Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil. diogogoulartcorrea@yahoo.com.br. Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, RJ, Brazil. diogogoulartcorrea@yahoo.com.br.Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil. Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil.Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, RJ, Brazil.Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil.Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil. Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, RJ, Brazil.Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil. Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil. Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, RJ, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27114079

Citation

Corrêa, Diogo Goulart, et al. "Evaluation of White Matter Integrity in Systemic Lupus Erythematosus By Diffusion Tensor Magnetic Resonance Imaging: a Study Using Tract-based Spatial Statistics." Neuroradiology, vol. 58, no. 8, 2016, pp. 819-25.
Corrêa DG, Zimmermann N, Pereira DB, et al. Evaluation of white matter integrity in systemic lupus erythematosus by diffusion tensor magnetic resonance imaging: a study using tract-based spatial statistics. Neuroradiology. 2016;58(8):819-25.
Corrêa, D. G., Zimmermann, N., Pereira, D. B., Doring, T. M., Netto, T. M., Ventura, N., Fonseca, R. P., & Gasparetto, E. L. (2016). Evaluation of white matter integrity in systemic lupus erythematosus by diffusion tensor magnetic resonance imaging: a study using tract-based spatial statistics. Neuroradiology, 58(8), 819-25. https://doi.org/10.1007/s00234-016-1688-8
Corrêa DG, et al. Evaluation of White Matter Integrity in Systemic Lupus Erythematosus By Diffusion Tensor Magnetic Resonance Imaging: a Study Using Tract-based Spatial Statistics. Neuroradiology. 2016;58(8):819-25. PubMed PMID: 27114079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of white matter integrity in systemic lupus erythematosus by diffusion tensor magnetic resonance imaging: a study using tract-based spatial statistics. AU - Corrêa,Diogo Goulart, AU - Zimmermann,Nicolle, AU - Pereira,Denis Batista, AU - Doring,Thomas M, AU - Netto,Tania Maria, AU - Ventura,Nina, AU - Fonseca,Rochele Paz, AU - Gasparetto,Emerson Leandro, Y1 - 2016/04/25/ PY - 2016/03/09/received PY - 2016/04/11/accepted PY - 2016/4/27/entrez PY - 2016/4/27/pubmed PY - 2018/2/6/medline KW - Demyelination KW - Diffusion tensor imaging KW - Magnetic resonance imaging KW - Systemic lupus erythematosus KW - Wallerian degeneration SP - 819 EP - 25 JF - Neuroradiology JO - Neuroradiology VL - 58 IS - 8 N2 - INTRODUCTION: The aim of this study was to evaluate the white matter integrity in brains of patients with systemic lupus erythematosus (SLE) using a voxel-based analyses of diffusion tensor imaging (DTI) data. METHODS: Fifty-seven patients with SLE were compared to 36 control patients who were matched by gender, age, education, and Mini Mental State Examination score. DTI was performed along 30 noncollinear directions in a 1.5 Tesla scanner. For tract-based spatial statistics (TBSS), a white matter skeleton was created, and a permutation-based inference with 5000 permutations and a threshold of p < 0.05 was used to identify abnormalities in fractional anisotropy (FA). The mean (MD), radial (RD), and axial diffusivities (AD) were also projected onto the mean FA skeleton. RESULTS: We found a significant decrease of global FA in SLE patients compared to controls. The areas of reduced FA included the right superior corona radiata, the right superior longitudinal fasciculus, the body of the corpus callosum, the right inferior fronto-occipital fasciculus, the right thalamic radiation, and the right uncinate fasciculus. Patients with SLE also had increased AD and RD in several areas. Substantial overlap of areas with increased AD and RD occurred and were spatially much more extensive than the areas of reduced FA. CONCLUSION: Significant increases of AD values were concordant to those of RD and MD and more extensive than FA changes. Analyzing all diffusivity parameters, using TBSS, can detect more white matter microstructural changes in patients with SLE than analyzing FA alone. SN - 1432-1920 UR - https://www.unboundmedicine.com/medline/citation/27114079/Evaluation_of_white_matter_integrity_in_systemic_lupus_erythematosus_by_diffusion_tensor_magnetic_resonance_imaging:_a_study_using_tract_based_spatial_statistics_ L2 - https://dx.doi.org/10.1007/s00234-016-1688-8 DB - PRIME DP - Unbound Medicine ER -