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Kerion and Tinea Corporis Caused by Rabbit-Derived Trichophyton interdigitale in Three Siblings and One Consulting Doctor Using β-Tubulin Gene to Identify the Pathogen.
Mycopathologia. 2016 Aug; 181(7-8):539-46.M

Abstract

Trichophyton interdigitale is generally deemed as an anamorph of Arthroderma vanbreuseghemii based on internal transcribed spacer (ITS) sequencing, but recently their anamorph/teleomorph connection should be cautioned based on β-tubulin phylogeny. We report three siblings and one consulting doctor who developed kerion and tinea corporis after contact with domestic rabbits. Seven same strains were isolated from four patients and three regions of a sick rabbit. The ITS and D1/D2 sequences of our isolate were 99 % homologous to A. Vanbreuseghemii, while β-tubulin sequence was 100 % identical to T. interdigitale. Our isolate was identified as T. interdigitale based on maximum likelihood analysis of β-tubulin. Random amplified polymorphic DNA revealed that the band patterns of five isolated strains and another rabbit-derived strain WCH023 were identical for OPF-03 and OPF-12. Skin lesions of all patients resolved completely for 2- to 6-week therapy of oral terbinafine and topical 1 % bifonazole or 1 % terbinafine cream. This study demonstrates that T. interdigitale of rabbit origin can cause various types of human dermatophytosis by mild scratch. Terbinafine may be the first choice for dermatophytosis caused by T. interdigitale.

Authors+Show Affiliations

Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China. ymfan1963@163.com.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

27115611

Citation

Yang, Yan-Ping, et al. "Kerion and Tinea Corporis Caused By Rabbit-Derived Trichophyton Interdigitale in Three Siblings and One Consulting Doctor Using β-Tubulin Gene to Identify the Pathogen." Mycopathologia, vol. 181, no. 7-8, 2016, pp. 539-46.
Yang YP, Sheng P, Liu Z, et al. Kerion and Tinea Corporis Caused by Rabbit-Derived Trichophyton interdigitale in Three Siblings and One Consulting Doctor Using β-Tubulin Gene to Identify the Pathogen. Mycopathologia. 2016;181(7-8):539-46.
Yang, Y. P., Sheng, P., Liu, Z., Li, W., Wang, J. D., Huang, W. M., & Fan, Y. M. (2016). Kerion and Tinea Corporis Caused by Rabbit-Derived Trichophyton interdigitale in Three Siblings and One Consulting Doctor Using β-Tubulin Gene to Identify the Pathogen. Mycopathologia, 181(7-8), 539-46. https://doi.org/10.1007/s11046-016-9998-2
Yang YP, et al. Kerion and Tinea Corporis Caused By Rabbit-Derived Trichophyton Interdigitale in Three Siblings and One Consulting Doctor Using β-Tubulin Gene to Identify the Pathogen. Mycopathologia. 2016;181(7-8):539-46. PubMed PMID: 27115611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kerion and Tinea Corporis Caused by Rabbit-Derived Trichophyton interdigitale in Three Siblings and One Consulting Doctor Using β-Tubulin Gene to Identify the Pathogen. AU - Yang,Yan-Ping, AU - Sheng,Ping, AU - Liu,Zhong, AU - Li,Wen, AU - Wang,Jie-Di, AU - Huang,Wen-Ming, AU - Fan,Yi-Ming, Y1 - 2016/04/26/ PY - 2015/04/27/received PY - 2016/03/02/accepted PY - 2016/4/27/entrez PY - 2016/4/27/pubmed PY - 2017/4/4/medline KW - Arthroderma vanbreuseghemii KW - Kerion KW - Rabbit KW - Tinea corporis KW - Trichophyton interdigitale SP - 539 EP - 46 JF - Mycopathologia JO - Mycopathologia VL - 181 IS - 7-8 N2 - Trichophyton interdigitale is generally deemed as an anamorph of Arthroderma vanbreuseghemii based on internal transcribed spacer (ITS) sequencing, but recently their anamorph/teleomorph connection should be cautioned based on β-tubulin phylogeny. We report three siblings and one consulting doctor who developed kerion and tinea corporis after contact with domestic rabbits. Seven same strains were isolated from four patients and three regions of a sick rabbit. The ITS and D1/D2 sequences of our isolate were 99 % homologous to A. Vanbreuseghemii, while β-tubulin sequence was 100 % identical to T. interdigitale. Our isolate was identified as T. interdigitale based on maximum likelihood analysis of β-tubulin. Random amplified polymorphic DNA revealed that the band patterns of five isolated strains and another rabbit-derived strain WCH023 were identical for OPF-03 and OPF-12. Skin lesions of all patients resolved completely for 2- to 6-week therapy of oral terbinafine and topical 1 % bifonazole or 1 % terbinafine cream. This study demonstrates that T. interdigitale of rabbit origin can cause various types of human dermatophytosis by mild scratch. Terbinafine may be the first choice for dermatophytosis caused by T. interdigitale. SN - 1573-0832 UR - https://www.unboundmedicine.com/medline/citation/27115611/Kerion_and_Tinea_Corporis_Caused_by_Rabbit_Derived_Trichophyton_interdigitale_in_Three_Siblings_and_One_Consulting_Doctor_Using_β_Tubulin_Gene_to_Identify_the_Pathogen_ L2 - https://dx.doi.org/10.1007/s11046-016-9998-2 DB - PRIME DP - Unbound Medicine ER -