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Transient testicular degeneration in rams fed locoweed (Astragalus lentiginosus).
Vet Hum Toxicol. 1989 Feb; 31(1):42-6.VH

Abstract

Locoweed (Astragalus lentiginosus) fed to mature rams induced transient degenerative changes in the seminiferous, epididymal and vas deferens epithelium. There were changes in behavior and loss of condition in the treatment rams. Observed libido was reduced. Estimated percent abnormal sperm was significantly (P less than 0.05) higher in the locoweed-fed rams than in the controls. Increased retained proximal cytoplasmic droplets, separation of the heads and tails of the spermatozoa, and reduced sperm motility were observed. Serum SGOT (serum glutamic oxaloacetic transaminase) levels were significantly (P less than 0.01) elevated, and WBC (white blood cell) counts were decreased (P less than 0.01). Grossly no changes were observed. Histologically there were advanced lesions of foamy cytoplasmic vacuolation in all tissues taken at necropsy, but particularly in the epithelium of the seminiferous tubules, epididymis and vas deferens. Reduced spermatozoa production was evident. Testicular changes were transient and rams appeared clinically normal 70 days after locoweed feeding was terminated; however, there was slight residual atrophy of the germinal epithelium at necropsy.

Authors+Show Affiliations

USDA/ARS/Poisonous Plant Research Laboratory, Logan, UT 84321.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2711606

Citation

Panter, K E., et al. "Transient Testicular Degeneration in Rams Fed Locoweed (Astragalus Lentiginosus)." Veterinary and Human Toxicology, vol. 31, no. 1, 1989, pp. 42-6.
Panter KE, James LF, Hartley WJ. Transient testicular degeneration in rams fed locoweed (Astragalus lentiginosus). Vet Hum Toxicol. 1989;31(1):42-6.
Panter, K. E., James, L. F., & Hartley, W. J. (1989). Transient testicular degeneration in rams fed locoweed (Astragalus lentiginosus). Veterinary and Human Toxicology, 31(1), 42-6.
Panter KE, James LF, Hartley WJ. Transient Testicular Degeneration in Rams Fed Locoweed (Astragalus Lentiginosus). Vet Hum Toxicol. 1989;31(1):42-6. PubMed PMID: 2711606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transient testicular degeneration in rams fed locoweed (Astragalus lentiginosus). AU - Panter,K E, AU - James,L F, AU - Hartley,W J, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 42 EP - 6 JF - Veterinary and human toxicology JO - Vet Hum Toxicol VL - 31 IS - 1 N2 - Locoweed (Astragalus lentiginosus) fed to mature rams induced transient degenerative changes in the seminiferous, epididymal and vas deferens epithelium. There were changes in behavior and loss of condition in the treatment rams. Observed libido was reduced. Estimated percent abnormal sperm was significantly (P less than 0.05) higher in the locoweed-fed rams than in the controls. Increased retained proximal cytoplasmic droplets, separation of the heads and tails of the spermatozoa, and reduced sperm motility were observed. Serum SGOT (serum glutamic oxaloacetic transaminase) levels were significantly (P less than 0.01) elevated, and WBC (white blood cell) counts were decreased (P less than 0.01). Grossly no changes were observed. Histologically there were advanced lesions of foamy cytoplasmic vacuolation in all tissues taken at necropsy, but particularly in the epithelium of the seminiferous tubules, epididymis and vas deferens. Reduced spermatozoa production was evident. Testicular changes were transient and rams appeared clinically normal 70 days after locoweed feeding was terminated; however, there was slight residual atrophy of the germinal epithelium at necropsy. SN - 0145-6296 UR - https://www.unboundmedicine.com/medline/citation/2711606/Transient_testicular_degeneration_in_rams_fed_locoweed__Astragalus_lentiginosus__ L2 - https://medlineplus.gov/testiculardisorders.html DB - PRIME DP - Unbound Medicine ER -