Abstract
After two decades of research on nutrition and dementia there is strong evidence for preventive effects of vitamin E, B vitamins, and n-3 fatty acids and deleterious effects of saturated fat on dementia. Among specific foods with evidence of neuroprotection are green leafy vegetables, other vegetables, berries, and seafood. A number of studies have examined dietary patterns, particularly the Mediterranean diet and DASH (Dietary Approaches to Stop Hypertension), neither of which is tailored to the specific foods and nutrients that have been identified as neuroprotective. A new diet called MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) incorporates many elements of the Mediterranean diet and DASH but with modifications that reflect current evidence for brain neuroprotection. The evidence in support of the relation of various nutrients and the Mediterranean diet to dementia has been inconsistent. The inconsistencies may be explained by inattention to nutrient/food intake levels in the interpretation of study findings and trial design, including a shifting metric among studies for scoring adherence to the Mediterranean diet. Future studies should pay particular attention to levels of intake in the design and analyses of nutritional studies.
TY - JOUR
T1 - Nutrition and risk of dementia: overview and methodological issues.
A1 - Morris,Martha Clare,
PY - 2015/11/10/received
PY - 2016/02/22/revised
PY - 2016/02/25/accepted
PY - 2017/03/01/pmc-release
PY - 2016/4/27/entrez
PY - 2016/4/27/pubmed
PY - 2017/7/15/medline
KW - Alzheimer's disease
KW - cognitive decline
KW - dementia
KW - diet patterns
SP - 31
EP - 7
JF - Annals of the New York Academy of Sciences
JO - Ann N Y Acad Sci
VL - 1367
IS - 1
N2 - After two decades of research on nutrition and dementia there is strong evidence for preventive effects of vitamin E, B vitamins, and n-3 fatty acids and deleterious effects of saturated fat on dementia. Among specific foods with evidence of neuroprotection are green leafy vegetables, other vegetables, berries, and seafood. A number of studies have examined dietary patterns, particularly the Mediterranean diet and DASH (Dietary Approaches to Stop Hypertension), neither of which is tailored to the specific foods and nutrients that have been identified as neuroprotective. A new diet called MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) incorporates many elements of the Mediterranean diet and DASH but with modifications that reflect current evidence for brain neuroprotection. The evidence in support of the relation of various nutrients and the Mediterranean diet to dementia has been inconsistent. The inconsistencies may be explained by inattention to nutrient/food intake levels in the interpretation of study findings and trial design, including a shifting metric among studies for scoring adherence to the Mediterranean diet. Future studies should pay particular attention to levels of intake in the design and analyses of nutritional studies.
SN - 1749-6632
UR - https://www.unboundmedicine.com/medline/citation/27116239/Nutrition_and_risk_of_dementia:_overview_and_methodological_issues_
L2 - https://doi.org/10.1111/nyas.13047
DB - PRIME
DP - Unbound Medicine
ER -