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Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease.
Pharmacol Rep. 2016 Jun; 68(3):507-13.PR

Abstract

Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 2001. It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs. Orbital IgG4-related disease is a recently reported issue that may prove important for the elucidation of the etiology of idiopathic, lymphoplasmacytic or fibrotic disorders of various organs, including the orbits. In this article, we are describing epidemiology and differential diagnostics of IgG4-related orbital disease with particular focus on pseudotumors, MALT lymphomas and lymphocyte/plasma cell infiltrations of the orbit. We are also discussing therapeutic possibilities currently available in the management of the disease.

Authors+Show Affiliations

Department of Oncological and Reconstructive Surgery, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, Poland. Electronic address: olokrista@op.pl.Department of Otolaryngology, Collegium Medicum, Jagiellonian University, Kraków, Poland. Electronic address: skladzien.j@interia.pl.Department of Cardiac and Vascular Surgery and Transplantology, The Institute of Cardiology, Medical College Jagiellonian University, John Paul II Hospital, Kraków, Poland. Electronic address: krzysztofbartus@gmail.com.Department of Otolaryngology, Collegium Medicum, Jagiellonian University, Kraków, Poland. Electronic address: johnka@wp.pl.Department of Otolaryngology, Collegium Medicum, Jagiellonian University, Kraków, Poland. Electronic address: emilabo@gmail.com.Department of Oncological and Reconstructive Surgery, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, Poland. Electronic address: lukaszkrakowczyk@wp.pl.Department of Pain Pharmacology, Institute of Pharmacology, Kraków, Poland. Electronic address: joasia272@onet.eu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27116895

Citation

Oles, Krzysztof, et al. "Characteristics, Diagnosis and Therapeutic Strategies for IgG4-related Orbital Disease." Pharmacological Reports : PR, vol. 68, no. 3, 2016, pp. 507-13.
Oles K, Sładzień J, Bartuś K, et al. Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease. Pharmacol Rep. 2016;68(3):507-13.
Oles, K., Sładzień, J., Bartuś, K., Leszczyńska, J., Bojanowska, E., Krakowczyk, Ł., & Mika, J. (2016). Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease. Pharmacological Reports : PR, 68(3), 507-13. https://doi.org/10.1016/j.pharep.2015.11.011
Oles K, et al. Characteristics, Diagnosis and Therapeutic Strategies for IgG4-related Orbital Disease. Pharmacol Rep. 2016;68(3):507-13. PubMed PMID: 27116895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease. AU - Oles,Krzysztof, AU - Sładzień,Jacek, AU - Bartuś,Krzysztof, AU - Leszczyńska,Joanna, AU - Bojanowska,Emila, AU - Krakowczyk,Łukasz, AU - Mika,Joanna, Y1 - 2015/12/22/ PY - 2015/10/12/received PY - 2015/11/30/revised PY - 2015/11/30/accepted PY - 2016/4/28/entrez PY - 2016/4/28/pubmed PY - 2017/6/28/medline KW - IgG4-related disease KW - Lymphocyte/plasma cell infiltrations KW - MALT lymphomas KW - Orbital pseudotumors SP - 507 EP - 13 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 68 IS - 3 N2 - Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 2001. It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs. Orbital IgG4-related disease is a recently reported issue that may prove important for the elucidation of the etiology of idiopathic, lymphoplasmacytic or fibrotic disorders of various organs, including the orbits. In this article, we are describing epidemiology and differential diagnostics of IgG4-related orbital disease with particular focus on pseudotumors, MALT lymphomas and lymphocyte/plasma cell infiltrations of the orbit. We are also discussing therapeutic possibilities currently available in the management of the disease. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/27116895/Characteristics_diagnosis_and_therapeutic_strategies_for_IgG4_related_orbital_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(15)00368-0 DB - PRIME DP - Unbound Medicine ER -