Tags

Type your tag names separated by a space and hit enter

Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals.
Alcohol Alcohol. 2016 Sep; 51(5):549-54.AA

Abstract

BACKGROUND

A single-nucleotide polymorphism (SNP) in GABRA2 (rs279858) may moderate subjective response (SR) to alcohol. Results of studies in non-dependent drinkers examining this GABRA2 SNP on SR have been equivocal. This study examined this SNP's direct and indirect effects on alcohol self-administration in dependent drinkers.

METHOD

The sample consisted of 63 Caucasian, non-treatment-seeking individuals with alcohol dependence. Subjective stimulation was assessed using the Biphasic Alcohol Effects Scale following consumption of an alcoholic priming drink (target breath alcohol content = 0.02 g%). Participants were subsequently offered the opportunity to self-administer up to eight additional drinks.

RESULTS

Controlling for baseline stimulation, T-allele homozygotes, relative to individuals with at least one copy of the C-allele, reported greater initial stimulation, t(58) = 2.011, p = 0.049. Greater stimulation predicted greater subsequent alcohol self-administration, t(57) = 2.522, p = 0.015. Although rs279858 genotype did not directly impact self-administration (t(57) = -0.674, p = 0.503), it did have an indirect effect (95% confidence interval [0.068, 1.576]), such that T-allele homozygotes reported greater stimulation, which in turn predicted greater self-administration.

CONCLUSION

These results suggest that the influence of this SNP on SR differs depending on dose or stage of dependence. This study is the first to demonstrate an indirect effect of rs279858 genotype on drinking through SR. Although C-allele carriers have been shown to have an increased risk for alcohol dependence, in our dependent sample, greater stimulation was found among T-allele homozygotes, suggesting that the influence of SR on developing and maintaining dependence differs based on rs279858 genotype.This study demonstrates an indirect effect of rs279858 genotype on drinking through SR. Although C-allele carriers have an increased risk for alcohol dependence, in our dependent sample, greater stimulation was found among T-allele homozygotes, suggesting that the influence of SR on developing dependence differs based on rs279858 genotype.

Authors+Show Affiliations

Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA antonr@musc.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27117237

Citation

Boyd, Stephen J., et al. "Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP On Alcohol Self-Administrated Among Alcohol-Dependent Individuals." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 51, no. 5, 2016, pp. 549-54.
Boyd SJ, Schacht JP, Prisciandaro JJ, et al. Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol Alcohol. 2016;51(5):549-54.
Boyd, S. J., Schacht, J. P., Prisciandaro, J. J., Voronin, K., & Anton, R. F. (2016). Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol and Alcoholism (Oxford, Oxfordshire), 51(5), 549-54. https://doi.org/10.1093/alcalc/agw024
Boyd SJ, et al. Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP On Alcohol Self-Administrated Among Alcohol-Dependent Individuals. Alcohol Alcohol. 2016;51(5):549-54. PubMed PMID: 27117237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. AU - Boyd,Stephen J, AU - Schacht,Joseph P, AU - Prisciandaro,James J, AU - Voronin,Konstantin, AU - Anton,Raymond F, Y1 - 2016/04/26/ PY - 2015/10/04/received PY - 2016/04/05/accepted PY - 2016/4/28/entrez PY - 2016/4/28/pubmed PY - 2017/1/25/medline SP - 549 EP - 54 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 51 IS - 5 N2 - BACKGROUND: A single-nucleotide polymorphism (SNP) in GABRA2 (rs279858) may moderate subjective response (SR) to alcohol. Results of studies in non-dependent drinkers examining this GABRA2 SNP on SR have been equivocal. This study examined this SNP's direct and indirect effects on alcohol self-administration in dependent drinkers. METHOD: The sample consisted of 63 Caucasian, non-treatment-seeking individuals with alcohol dependence. Subjective stimulation was assessed using the Biphasic Alcohol Effects Scale following consumption of an alcoholic priming drink (target breath alcohol content = 0.02 g%). Participants were subsequently offered the opportunity to self-administer up to eight additional drinks. RESULTS: Controlling for baseline stimulation, T-allele homozygotes, relative to individuals with at least one copy of the C-allele, reported greater initial stimulation, t(58) = 2.011, p = 0.049. Greater stimulation predicted greater subsequent alcohol self-administration, t(57) = 2.522, p = 0.015. Although rs279858 genotype did not directly impact self-administration (t(57) = -0.674, p = 0.503), it did have an indirect effect (95% confidence interval [0.068, 1.576]), such that T-allele homozygotes reported greater stimulation, which in turn predicted greater self-administration. CONCLUSION: These results suggest that the influence of this SNP on SR differs depending on dose or stage of dependence. This study is the first to demonstrate an indirect effect of rs279858 genotype on drinking through SR. Although C-allele carriers have been shown to have an increased risk for alcohol dependence, in our dependent sample, greater stimulation was found among T-allele homozygotes, suggesting that the influence of SR on developing and maintaining dependence differs based on rs279858 genotype.This study demonstrates an indirect effect of rs279858 genotype on drinking through SR. Although C-allele carriers have an increased risk for alcohol dependence, in our dependent sample, greater stimulation was found among T-allele homozygotes, suggesting that the influence of SR on developing dependence differs based on rs279858 genotype. SN - 1464-3502 UR - https://www.unboundmedicine.com/medline/citation/27117237/Alcohol_Induced_Stimulation_Mediates_the_Effect_of_a_GABRA2_SNP_on_Alcohol_Self_Administrated_among_Alcohol_Dependent_Individuals_ L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agw024 DB - PRIME DP - Unbound Medicine ER -