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MicroRNAs underlying memory deficits in neurodegenerative disorders.

Abstract

Neurodegenerative disorders are defined by neuronal loss and often associated with dementia. Understanding the multifactorial nature of cognitive decline is of particular interest. Cell loss is certainly a possibility but also an early imbalance in the complex gene networks involved in learning and memory. The small (~22nt) non-coding microRNAs play a major role in gene expression regulation and have been linked to neuronal survival and cognition. Interestingly, changes in microRNA signatures are associated with neurodegenerative disorders. In this review, we explore the role of three microRNAs, namely miR-132, miR-124 and miR-34, which are dysregulated in major neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Interestingly, these microRNAs have been associated with both memory impairment and neuronal survival, providing a potential common molecular mechanism contributing to dementia.

Authors+Show Affiliations

Axe Neurosciences, Centre de recherche du CHU de Québec, CHUL, Québec, QC, G1V4G2, Canada; Département de psychiatrie et neurosciences, Université Laval, Québec, QC, G1V 0A6, Canada.Axe Neurosciences, Centre de recherche du CHU de Québec, CHUL, Québec, QC, G1V4G2, Canada; Département de psychiatrie et neurosciences, Université Laval, Québec, QC, G1V 0A6, Canada.Axe Neurosciences, Centre de recherche du CHU de Québec, CHUL, Québec, QC, G1V4G2, Canada; Département de psychiatrie et neurosciences, Université Laval, Québec, QC, G1V 0A6, Canada. Electronic address: sebastien.hebert@neurosciences.ulaval.ca.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27117821

Citation

Hernandez-Rapp, Julia, et al. "MicroRNAs Underlying Memory Deficits in Neurodegenerative Disorders." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 73, 2017, pp. 79-86.
Hernandez-Rapp J, Rainone S, Hébert SS. MicroRNAs underlying memory deficits in neurodegenerative disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2017;73:79-86.
Hernandez-Rapp, J., Rainone, S., & Hébert, S. S. (2017). MicroRNAs underlying memory deficits in neurodegenerative disorders. Progress in Neuro-psychopharmacology & Biological Psychiatry, 73, 79-86. https://doi.org/10.1016/j.pnpbp.2016.04.011
Hernandez-Rapp J, Rainone S, Hébert SS. MicroRNAs Underlying Memory Deficits in Neurodegenerative Disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2017 02 6;73:79-86. PubMed PMID: 27117821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNAs underlying memory deficits in neurodegenerative disorders. AU - Hernandez-Rapp,Julia, AU - Rainone,Sara, AU - Hébert,Sébastien S, Y1 - 2016/04/23/ PY - 2016/02/01/received PY - 2016/04/01/revised PY - 2016/04/22/accepted PY - 2016/4/28/pubmed PY - 2017/8/31/medline PY - 2016/4/28/entrez KW - Dementia KW - Neurodegenerative disorders KW - miR-124 KW - miR-132 KW - miR-34 SP - 79 EP - 86 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 73 N2 - Neurodegenerative disorders are defined by neuronal loss and often associated with dementia. Understanding the multifactorial nature of cognitive decline is of particular interest. Cell loss is certainly a possibility but also an early imbalance in the complex gene networks involved in learning and memory. The small (~22nt) non-coding microRNAs play a major role in gene expression regulation and have been linked to neuronal survival and cognition. Interestingly, changes in microRNA signatures are associated with neurodegenerative disorders. In this review, we explore the role of three microRNAs, namely miR-132, miR-124 and miR-34, which are dysregulated in major neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Interestingly, these microRNAs have been associated with both memory impairment and neuronal survival, providing a potential common molecular mechanism contributing to dementia. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/27117821/MicroRNAs_underlying_memory_deficits_in_neurodegenerative_disorders_ DB - PRIME DP - Unbound Medicine ER -