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Relationship between advanced glycation end-product accumulation and low skeletal muscle mass in Japanese men and women.
Geriatr Gerontol Int 2017; 17(5):785-790GG

Abstract

AIM

The present study aimed to investigate the relationship between advanced glycation end-product accumulation and skeletal muscle mass among middle-aged and older Japanese men and women.

METHODS

A total of 132 participants enrolled in this cross-sectional study. Skin autofluorescence was assessed as a measure of advanced glycation-end products. Appendicular skeletal muscle mass was measured using dual-energy X-ray absorptiometry, and skeletal muscle index was calculated by dividing appendicular skeletal muscle mass by height squared. Participants were divided into two groups (low skeletal muscle index and normal skeletal muscle index) using the Asian Working Group for Sarcopenia's skeletal muscle index criteria for diagnosing sarcopenia. Multivariate logistic regression analysis and the area under the receiver operating characteristic curve were used to determine significant factors associated with low skeletal muscle index.

RESULTS

Participants consisted of 70 men (mean age 57 ± 10 years) and 62 women (mean age 60 ± 11 years). There were 31 and 101 participants in the low and normal skeletal muscle index groups, respectively. Skin autofluorescence was significantly higher in the low skeletal muscle index group compared with the normal skeletal muscle index group (P < 0.01). Skin autofluorescence was a significant independent factor associated with low skeletal muscle index based on multivariate logistic regression analysis (odds ratio 15.7, 95% confidence interval 1.85-133.01; P = 0.012). The cut-off for skin autofluorescence was 2.45 arbitrary units, with a sensitivity of 0.75 and specificity of 0.91.

CONCLUSIONS

Skin autofluorescence was an independent factor associated with low skeletal muscle index among middle-aged and older Japanese men and women. Geriatr Gerontol Int 2017; 17: 785-790.

Authors+Show Affiliations

Department of Shizuoka Physical Therapy, Faculty of Health Science, Tokoha University, Shizuoka, Japan. Anti-aging Center, Ginza Clinic, Tokyo, Japan.Department of Shizuoka Physical Therapy, Faculty of Health Science, Tokoha University, Shizuoka, Japan. Anti-aging Center, Ginza Clinic, Tokyo, Japan.Department of Clinical Laboratory, Ginza Clinic, Tokyo, Japan.Department of Clinical Laboratory, Ginza Clinic, Tokyo, Japan.Department of Clinical Laboratory, Ginza Clinic, Tokyo, Japan.Anti-aging Center, Ginza Clinic, Tokyo, Japan.Department of Internal Medicine, Ginza Hospital, Tokyo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27119258

Citation

Kato, Michitaka, et al. "Relationship Between Advanced Glycation End-product Accumulation and Low Skeletal Muscle Mass in Japanese Men and Women." Geriatrics & Gerontology International, vol. 17, no. 5, 2017, pp. 785-790.
Kato M, Kubo A, Sugioka Y, et al. Relationship between advanced glycation end-product accumulation and low skeletal muscle mass in Japanese men and women. Geriatr Gerontol Int. 2017;17(5):785-790.
Kato, M., Kubo, A., Sugioka, Y., Mitsui, R., Fukuhara, N., Nihei, F., & Takeda, Y. (2017). Relationship between advanced glycation end-product accumulation and low skeletal muscle mass in Japanese men and women. Geriatrics & Gerontology International, 17(5), pp. 785-790. doi:10.1111/ggi.12787.
Kato M, et al. Relationship Between Advanced Glycation End-product Accumulation and Low Skeletal Muscle Mass in Japanese Men and Women. Geriatr Gerontol Int. 2017;17(5):785-790. PubMed PMID: 27119258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between advanced glycation end-product accumulation and low skeletal muscle mass in Japanese men and women. AU - Kato,Michitaka, AU - Kubo,Akira, AU - Sugioka,Yosuke, AU - Mitsui,Rie, AU - Fukuhara,Nobuki, AU - Nihei,Fumi, AU - Takeda,Yoshihiko, Y1 - 2016/04/27/ PY - 2016/01/05/received PY - 2016/02/16/revised PY - 2016/02/24/accepted PY - 2016/4/28/pubmed PY - 2018/4/5/medline PY - 2016/4/28/entrez KW - advanced glycation end-product KW - oxidative stress KW - skeletal muscle mass KW - skin autofluorescence SP - 785 EP - 790 JF - Geriatrics & gerontology international JO - Geriatr Gerontol Int VL - 17 IS - 5 N2 - AIM: The present study aimed to investigate the relationship between advanced glycation end-product accumulation and skeletal muscle mass among middle-aged and older Japanese men and women. METHODS: A total of 132 participants enrolled in this cross-sectional study. Skin autofluorescence was assessed as a measure of advanced glycation-end products. Appendicular skeletal muscle mass was measured using dual-energy X-ray absorptiometry, and skeletal muscle index was calculated by dividing appendicular skeletal muscle mass by height squared. Participants were divided into two groups (low skeletal muscle index and normal skeletal muscle index) using the Asian Working Group for Sarcopenia's skeletal muscle index criteria for diagnosing sarcopenia. Multivariate logistic regression analysis and the area under the receiver operating characteristic curve were used to determine significant factors associated with low skeletal muscle index. RESULTS: Participants consisted of 70 men (mean age 57 ± 10 years) and 62 women (mean age 60 ± 11 years). There were 31 and 101 participants in the low and normal skeletal muscle index groups, respectively. Skin autofluorescence was significantly higher in the low skeletal muscle index group compared with the normal skeletal muscle index group (P < 0.01). Skin autofluorescence was a significant independent factor associated with low skeletal muscle index based on multivariate logistic regression analysis (odds ratio 15.7, 95% confidence interval 1.85-133.01; P = 0.012). The cut-off for skin autofluorescence was 2.45 arbitrary units, with a sensitivity of 0.75 and specificity of 0.91. CONCLUSIONS: Skin autofluorescence was an independent factor associated with low skeletal muscle index among middle-aged and older Japanese men and women. Geriatr Gerontol Int 2017; 17: 785-790. SN - 1447-0594 UR - https://www.unboundmedicine.com/medline/citation/27119258/Relationship_between_advanced_glycation_end_product_accumulation_and_low_skeletal_muscle_mass_in_Japanese_men_and_women_ L2 - https://doi.org/10.1111/ggi.12787 DB - PRIME DP - Unbound Medicine ER -