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[The solutibility of local anaesthetics in cerebrospinal fluid and the dependency of the process on the hydrogene ion concentration (author's transl)].
Anaesthesist. 1978 May; 27(5):suppl 32-7.A

Abstract

Reports on in vitro precipitation of local anesthetics suggested the possibility of a damaging effect on nervous tissue with spinal anesthesia. The present assays showed that the solubility of local anesthetics in aqueous media decreases with rising pH-levels. The partial pressure of CO2 determines the pH-level of the cerebrospinal fluid, the level ranging at about 7.35 + 0.011 (95% range: 7.327-7.371). The solubilities calculated for a pH of 7.371 (at 37 degrees C) are as follows: Bupivacaine.HCl 0.83+/-0.10 mh/ml Carticaine.HCl 27 +/-2.8 mg/ml Lidocaine.HCl 24 +/-1.3 mg/ml Mepivacaine.HCl 14.8 +/- 0.2 mg/ml Tetracaine.HCl 1.4 +/- 0.12 mg/ml.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

27123

Citation

Dudziak, R, and M Uihlein. "[The Solutibility of Local Anaesthetics in Cerebrospinal Fluid and the Dependency of the Process On the Hydrogene Ion Concentration (author's Transl)]." Der Anaesthesist, vol. 27, no. 5, 1978, pp. suppl 32-7.
Dudziak R, Uihlein M. [The solutibility of local anaesthetics in cerebrospinal fluid and the dependency of the process on the hydrogene ion concentration (author's transl)]. Anaesthesist. 1978;27(5):suppl 32-7.
Dudziak, R., & Uihlein, M. (1978). [The solutibility of local anaesthetics in cerebrospinal fluid and the dependency of the process on the hydrogene ion concentration (author's transl)]. Der Anaesthesist, 27(5), suppl 32-7.
Dudziak R, Uihlein M. [The Solutibility of Local Anaesthetics in Cerebrospinal Fluid and the Dependency of the Process On the Hydrogene Ion Concentration (author's Transl)]. Anaesthesist. 1978;27(5):suppl 32-7. PubMed PMID: 27123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The solutibility of local anaesthetics in cerebrospinal fluid and the dependency of the process on the hydrogene ion concentration (author's transl)]. AU - Dudziak,R, AU - Uihlein,M, PY - 1978/5/1/pubmed PY - 1978/5/1/medline PY - 1978/5/1/entrez SP - suppl 32 EP - 7 JF - Der Anaesthesist JO - Anaesthesist VL - 27 IS - 5 N2 - Reports on in vitro precipitation of local anesthetics suggested the possibility of a damaging effect on nervous tissue with spinal anesthesia. The present assays showed that the solubility of local anesthetics in aqueous media decreases with rising pH-levels. The partial pressure of CO2 determines the pH-level of the cerebrospinal fluid, the level ranging at about 7.35 + 0.011 (95% range: 7.327-7.371). The solubilities calculated for a pH of 7.371 (at 37 degrees C) are as follows: Bupivacaine.HCl 0.83+/-0.10 mh/ml Carticaine.HCl 27 +/-2.8 mg/ml Lidocaine.HCl 24 +/-1.3 mg/ml Mepivacaine.HCl 14.8 +/- 0.2 mg/ml Tetracaine.HCl 1.4 +/- 0.12 mg/ml. SN - 0003-2417 UR - https://www.unboundmedicine.com/medline/citation/27123/[The_solutibility_of_local_anaesthetics_in_cerebrospinal_fluid_and_the_dependency_of_the_process_on_the_hydrogene_ion_concentration__author's_transl_]_ L2 - http://RD3FS2PT9J.search.serialssolutions.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqm&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&issn=0003-2417&eissn=1432-055X&volume=27&issue=5&spage=suppl&date=1978 DB - PRIME DP - Unbound Medicine ER -