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[pH of the cerebro spinal fluid during subdural block (author's transl)].
Anaesthesist. 1978 May; 27(5):suppl 41-3.A

Abstract

This study was initiated by other authors who found that bupivacaine precipitated together with spinal fluid in vitro and who assumed that during spinal anaesthesia complications might be possible. Under the influence of several local anaesthetic agents the pH of the spinal fluid and in 160 cases the precipitation was examined. There was no precipitation. The experimental conditions were nearly in vivo conditions. The results differed clearly from those in vitro. While in vitro bupivacaine precipitated from a pH higher than 7.37 in concentrations higher than 0.8 mg/ml [2], the pH of the spinal fluid in vivo was lower than 7.35 continually and the concentration of bupivacaine not higher than 0.3 mg/ml. This means that the border of bupivacaine precipitation is by far not reached in vivo and that complications therefore are not possible.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

27124

Citation

Stark, P, and H Nolte. "[pH of the Cerebro Spinal Fluid During Subdural Block (author's Transl)]." Der Anaesthesist, vol. 27, no. 5, 1978, pp. suppl 41-3.
Stark P, Nolte H. [pH of the cerebro spinal fluid during subdural block (author's transl)]. Anaesthesist. 1978;27(5):suppl 41-3.
Stark, P., & Nolte, H. (1978). [pH of the cerebro spinal fluid during subdural block (author's transl)]. Der Anaesthesist, 27(5), suppl 41-3.
Stark P, Nolte H. [pH of the Cerebro Spinal Fluid During Subdural Block (author's Transl)]. Anaesthesist. 1978;27(5):suppl 41-3. PubMed PMID: 27124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [pH of the cerebro spinal fluid during subdural block (author's transl)]. AU - Stark,P, AU - Nolte,H, PY - 1978/5/1/pubmed PY - 1978/5/1/medline PY - 1978/5/1/entrez SP - suppl 41 EP - 3 JF - Der Anaesthesist JO - Anaesthesist VL - 27 IS - 5 N2 - This study was initiated by other authors who found that bupivacaine precipitated together with spinal fluid in vitro and who assumed that during spinal anaesthesia complications might be possible. Under the influence of several local anaesthetic agents the pH of the spinal fluid and in 160 cases the precipitation was examined. There was no precipitation. The experimental conditions were nearly in vivo conditions. The results differed clearly from those in vitro. While in vitro bupivacaine precipitated from a pH higher than 7.37 in concentrations higher than 0.8 mg/ml [2], the pH of the spinal fluid in vivo was lower than 7.35 continually and the concentration of bupivacaine not higher than 0.3 mg/ml. This means that the border of bupivacaine precipitation is by far not reached in vivo and that complications therefore are not possible. SN - 0003-2417 UR - https://www.unboundmedicine.com/medline/citation/27124/[pH_of_the_cerebro_spinal_fluid_during_subdural_block__author's_transl_]_ DB - PRIME DP - Unbound Medicine ER -
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