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Pooled influenza vaccine effectiveness estimates for Australia, 2012-2014.
Epidemiol Infect. 2016 08; 144(11):2317-28.EI

Abstract

Data were pooled from three Australian sentinel general practice influenza surveillance networks to estimate Australia-wide influenza vaccine coverage and effectiveness against community presentations for laboratory-confirmed influenza for the 2012, 2013 and 2014 seasons. Patients presenting with influenza-like illness at participating GP practices were swabbed and tested for influenza. The vaccination odds of patients testing positive were compared with patients testing negative to estimate influenza vaccine effectiveness (VE) by logistic regression, adjusting for age group, week of presentation and network. Pooling of data across Australia increased the sample size for estimation from a minimum of 684 to 3,683 in 2012, from 314 to 2,042 in 2013 and from 497 to 3,074 in 2014. Overall VE was 38% [95% confidence interval (CI) 24-49] in 2012, 60% (95% CI 45-70) in 2013 and 44% (95% CI 31-55) in 2014. For A(H1N1)pdm09 VE was 54% (95% CI-28 to 83) in 2012, 59% (95% CI 33-74) in 2013 and 55% (95% CI 39-67) in 2014. For A(H3N2), VE was 30% (95% CI 14-44) in 2012, 67% (95% CI 39-82) in 2013 and 26% (95% CI 1-45) in 2014. For influenza B, VE was stable across years at 56% (95% CI 37-70) in 2012, 57% (95% CI 30-73) in 2013 and 54% (95% CI 21-73) in 2014. Overall VE against influenza was low in 2012 and 2014 when A(H3N2) was the dominant strain and the vaccine was poorly matched. In contrast, overall VE was higher in 2013 when A(H1N1)pdm09 dominated and the vaccine was a better match. Pooling data can increase the sample available and enable more precise subtype- and age group-specific estimates, but limitations remain.

Authors+Show Affiliations

WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute for Infection and Immunity,Melbourne,Victoria,Australia;Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity,Melbourne,Victoria,Australia;Discipline of General Practice,University of Adelaide,Adelaide,South Australia,Australia;School of Population and Global Health, University of Melbourne,Victoria,Australia;Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity,Melbourne,Victoria,Australia;School of Population and Global Health, University of Melbourne,Victoria,Australia;PathWest Laboratory Medicine,Perth,Western Australia,Australia;Discipline of General Practice,University of Adelaide,Adelaide,South Australia,Australia;PathWest Laboratory Medicine,Perth,Western Australia,Australia;School of Pathology and Laboratory Medicine,University of Western Australia,Perth,Western Australia,Australia;

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27125368

Citation

Sullivan, S G., et al. "Pooled Influenza Vaccine Effectiveness Estimates for Australia, 2012-2014." Epidemiology and Infection, vol. 144, no. 11, 2016, pp. 2317-28.
Sullivan SG, Carville KS, Chilver M, et al. Pooled influenza vaccine effectiveness estimates for Australia, 2012-2014. Epidemiol Infect. 2016;144(11):2317-28.
Sullivan, S. G., Carville, K. S., Chilver, M., Fielding, J. E., Grant, K. A., Kelly, H., Levy, A., Stocks, N. P., Tempone, S. S., & Regan, A. K. (2016). Pooled influenza vaccine effectiveness estimates for Australia, 2012-2014. Epidemiology and Infection, 144(11), 2317-28. https://doi.org/10.1017/S0950268816000819
Sullivan SG, et al. Pooled Influenza Vaccine Effectiveness Estimates for Australia, 2012-2014. Epidemiol Infect. 2016;144(11):2317-28. PubMed PMID: 27125368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pooled influenza vaccine effectiveness estimates for Australia, 2012-2014. AU - Sullivan,S G, AU - Carville,K S, AU - Chilver,M, AU - Fielding,J E, AU - Grant,K A, AU - Kelly,H, AU - Levy,A, AU - Stocks,N P, AU - Tempone,S S, AU - Regan,A K, Y1 - 2016/04/29/ PY - 2016/4/30/entrez PY - 2016/4/30/pubmed PY - 2017/6/2/medline KW - Influenza KW - influenza season KW - influenza vaccine KW - influenza-like illness KW - vaccine effectiveness SP - 2317 EP - 28 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 144 IS - 11 N2 - Data were pooled from three Australian sentinel general practice influenza surveillance networks to estimate Australia-wide influenza vaccine coverage and effectiveness against community presentations for laboratory-confirmed influenza for the 2012, 2013 and 2014 seasons. Patients presenting with influenza-like illness at participating GP practices were swabbed and tested for influenza. The vaccination odds of patients testing positive were compared with patients testing negative to estimate influenza vaccine effectiveness (VE) by logistic regression, adjusting for age group, week of presentation and network. Pooling of data across Australia increased the sample size for estimation from a minimum of 684 to 3,683 in 2012, from 314 to 2,042 in 2013 and from 497 to 3,074 in 2014. Overall VE was 38% [95% confidence interval (CI) 24-49] in 2012, 60% (95% CI 45-70) in 2013 and 44% (95% CI 31-55) in 2014. For A(H1N1)pdm09 VE was 54% (95% CI-28 to 83) in 2012, 59% (95% CI 33-74) in 2013 and 55% (95% CI 39-67) in 2014. For A(H3N2), VE was 30% (95% CI 14-44) in 2012, 67% (95% CI 39-82) in 2013 and 26% (95% CI 1-45) in 2014. For influenza B, VE was stable across years at 56% (95% CI 37-70) in 2012, 57% (95% CI 30-73) in 2013 and 54% (95% CI 21-73) in 2014. Overall VE against influenza was low in 2012 and 2014 when A(H3N2) was the dominant strain and the vaccine was poorly matched. In contrast, overall VE was higher in 2013 when A(H1N1)pdm09 dominated and the vaccine was a better match. Pooling data can increase the sample available and enable more precise subtype- and age group-specific estimates, but limitations remain. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/27125368/Pooled_influenza_vaccine_effectiveness_estimates_for_Australia_2012_2014_ L2 - https://www.cambridge.org/core/product/identifier/S0950268816000819/type/journal_article DB - PRIME DP - Unbound Medicine ER -