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Cryptococcus neoformans var. grubii-Induced Arthritis with Encephalitic Dissemination in a Dog and Review of Published Literature.
Mycopathologia. 2016 Aug; 181(7-8):595-601.M

Abstract

This article describes the clinical, pathological, and immunohistochemical findings associated with Cryptococcus neoformans var. grubii in a 4-year-old female Boxer dog from Uberlândia, Minas Gerais, Southeastern Brazil. Clinically, there was a swelling at the right metatarsal region and the hock joint with enlargement of regional lymph nodes. Radiographical evaluation revealed lysis of the tarsal bone; cytology demonstrated cryptococcal intralesional organisms at the swollen joint. Despite empirical antifungals therapeutic, the animal developed neurological cryptococcosis and died spontaneously. Significant pathological alterations included arthritis, lymphadenitis, and encephalitic cryptococcomas associated with numerous intralesional narrow-necked budding encapsulated yeasts. Immunohistochemistry utilising monoclonal antibodies that label C. neoformans sp. complex capsule, characterised the yeasts as C. neoformans var. grubii. Collectively, the pathological and immunohistochemical findings of this dog indicate that the intralesional organisms observed within the articular surface of the hock joint, lymph nodes, and the brain were C. neoformans var. grubii, confirming the participation of this fungal pathogen in the development of cryptococcal arthritis. In this case, the most likely pathogenesis was percutaneous inoculation with resultant abscess-like lesion, which resulted in the draining sinus, swelling of the right hind limb with progression to the articular disease. Thereafter, the fungal pathogen probably compromised the adjacent lymph nodes with subsequent haematogenous distribution to the brain, terminating with cryptococcal arthritis, lymphadenitis, and encephalitis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Headley SA
Laboratory of Animal Pathology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, PR 445 Km 380, Campus Universitário, PO Box 10.011, Londrina, Paraná, 86057-970, Brazil. selwyn.headley@uel.br.
Mota FC
Faculty of Veterinary Medicine, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.
Lindsay S
Department of Veterinary Pathology, Faculty of Veterinary Science, University of Sydney, Sydney, Australia.
de Oliveira LM
Laboratory of Mycology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
Medeiros AA
Faculty of Veterinary Medicine, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.
Pretto-Giordano LG
Laboratory of Mycology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
Saut JP
Faculty of Veterinary Medicine, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.
Krockenberger M
Department of Veterinary Pathology, Faculty of Veterinary Science, University of Sydney, Sydney, Australia.

MeSH

AnimalsArthritisBrazilCryptococcosisCryptococcus neoformansCytological TechniquesDog DiseasesDogsEncephalitisFemaleHistocytochemistryImmunohistochemistryMicroscopy

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

27126588

Citation

Headley, Selwyn Arlington, et al. "Cryptococcus Neoformans Var. grubii-Induced Arthritis With Encephalitic Dissemination in a Dog and Review of Published Literature." Mycopathologia, vol. 181, no. 7-8, 2016, pp. 595-601.
Headley SA, Mota FC, Lindsay S, et al. Cryptococcus neoformans var. grubii-Induced Arthritis with Encephalitic Dissemination in a Dog and Review of Published Literature. Mycopathologia. 2016;181(7-8):595-601.
Headley, S. A., Mota, F. C., Lindsay, S., de Oliveira, L. M., Medeiros, A. A., Pretto-Giordano, L. G., Saut, J. P., & Krockenberger, M. (2016). Cryptococcus neoformans var. grubii-Induced Arthritis with Encephalitic Dissemination in a Dog and Review of Published Literature. Mycopathologia, 181(7-8), 595-601. https://doi.org/10.1007/s11046-016-0009-4
Headley SA, et al. Cryptococcus Neoformans Var. grubii-Induced Arthritis With Encephalitic Dissemination in a Dog and Review of Published Literature. Mycopathologia. 2016;181(7-8):595-601. PubMed PMID: 27126588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cryptococcus neoformans var. grubii-Induced Arthritis with Encephalitic Dissemination in a Dog and Review of Published Literature. AU - Headley,Selwyn Arlington, AU - Mota,Francisco Claudio D, AU - Lindsay,Scott, AU - de Oliveira,Luiza M, AU - Medeiros,Alessandra Aparecida, AU - Pretto-Giordano,Lucienne Garcia, AU - Saut,João Paulo Elsen, AU - Krockenberger,Mark, Y1 - 2016/04/28/ PY - 2015/11/20/received PY - 2016/04/17/accepted PY - 2016/4/30/entrez PY - 2016/4/30/pubmed PY - 2017/4/4/medline KW - Canine KW - Cryptococcus neoformans var. grubii KW - Hock joint KW - Immunohistochemistry KW - Pathogenesis SP - 595 EP - 601 JF - Mycopathologia JO - Mycopathologia VL - 181 IS - 7-8 N2 - This article describes the clinical, pathological, and immunohistochemical findings associated with Cryptococcus neoformans var. grubii in a 4-year-old female Boxer dog from Uberlândia, Minas Gerais, Southeastern Brazil. Clinically, there was a swelling at the right metatarsal region and the hock joint with enlargement of regional lymph nodes. Radiographical evaluation revealed lysis of the tarsal bone; cytology demonstrated cryptococcal intralesional organisms at the swollen joint. Despite empirical antifungals therapeutic, the animal developed neurological cryptococcosis and died spontaneously. Significant pathological alterations included arthritis, lymphadenitis, and encephalitic cryptococcomas associated with numerous intralesional narrow-necked budding encapsulated yeasts. Immunohistochemistry utilising monoclonal antibodies that label C. neoformans sp. complex capsule, characterised the yeasts as C. neoformans var. grubii. Collectively, the pathological and immunohistochemical findings of this dog indicate that the intralesional organisms observed within the articular surface of the hock joint, lymph nodes, and the brain were C. neoformans var. grubii, confirming the participation of this fungal pathogen in the development of cryptococcal arthritis. In this case, the most likely pathogenesis was percutaneous inoculation with resultant abscess-like lesion, which resulted in the draining sinus, swelling of the right hind limb with progression to the articular disease. Thereafter, the fungal pathogen probably compromised the adjacent lymph nodes with subsequent haematogenous distribution to the brain, terminating with cryptococcal arthritis, lymphadenitis, and encephalitis. SN - 1573-0832 UR - https://www.unboundmedicine.com/medline/citation/27126588/Cryptococcus_neoformans_var__grubii_Induced_Arthritis_with_Encephalitic_Dissemination_in_a_Dog_and_Review_of_Published_Literature_ DB - PRIME DP - Unbound Medicine ER -