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Taste-masking properties of solid lipid based micropellets obtained by cold extrusion-spheronization.
Int J Pharm. 2016 Jun 15; 506(1-2):361-70.IJ

Abstract

Taste-masked properties of micropellets based on hard fat and/or solid lipid mixtures (prepared by solvent-free cold extrusion/spheronization), containing metformin hydrochloride were investigated. An in-line and an on-line drug release profile evaluation of the pellets was performed and further correlated with an electronic tongue investigation. The pellets based on more than 30% of lipid binders showed metformin HCl releases below 10% after 30s of dissolution. Micropellets based on 20 and 30% of lipids showed immediate drug release profiles. Likewise, the electronic tongue assay showed a decrease in the sensor responses related to the increase of lipid amount in the formulations denoting a significant improvement in the taste masking properties of pellets based on more than 30% of lipid binders. A slight difference between pellets based on hard fat only and pellets based on ternary lipid mixtures was evidenced. Solvent-free cold extrusion/spheronization using solid lipids showed to be a robust method to obtain high drug loaded metformin HCl micropellets with adequate taste-masked properties and immediate drug release profile.

Authors+Show Affiliations

Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetstrasse 1, 40225, Duesseldorf, Germany. Electronic address: Gustavo.Petrovick@hhu.de.Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetstrasse 1, 40225, Duesseldorf, Germany.Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetstrasse 1, 40225, Duesseldorf, Germany; Life Science Technologies, University of Applied Sciences Ostwestfalen-Lippe, Georg-Weerth-Strasse 20, 32756 Detmold, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27132502

Citation

Petrovick, Gustavo Freire, et al. "Taste-masking Properties of Solid Lipid Based Micropellets Obtained By Cold Extrusion-spheronization." International Journal of Pharmaceutics, vol. 506, no. 1-2, 2016, pp. 361-70.
Petrovick GF, Breitkreutz J, Pein-Hackelbusch M. Taste-masking properties of solid lipid based micropellets obtained by cold extrusion-spheronization. Int J Pharm. 2016;506(1-2):361-70.
Petrovick, G. F., Breitkreutz, J., & Pein-Hackelbusch, M. (2016). Taste-masking properties of solid lipid based micropellets obtained by cold extrusion-spheronization. International Journal of Pharmaceutics, 506(1-2), 361-70. https://doi.org/10.1016/j.ijpharm.2016.04.058
Petrovick GF, Breitkreutz J, Pein-Hackelbusch M. Taste-masking Properties of Solid Lipid Based Micropellets Obtained By Cold Extrusion-spheronization. Int J Pharm. 2016 Jun 15;506(1-2):361-70. PubMed PMID: 27132502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taste-masking properties of solid lipid based micropellets obtained by cold extrusion-spheronization. AU - Petrovick,Gustavo Freire, AU - Breitkreutz,Jörg, AU - Pein-Hackelbusch,Miriam, Y1 - 2016/04/28/ PY - 2016/03/21/received PY - 2016/04/20/revised PY - 2016/04/21/accepted PY - 2016/5/3/entrez PY - 2016/5/3/pubmed PY - 2017/4/11/medline KW - Cold extrusion KW - Drug release KW - Electronic tongue KW - Lipid pellets KW - Metformin hydrochloride KW - Metformin hydrochloride (PubChem CID: 14219) KW - Spheronization KW - Taste masking KW - glyceryl distearate (PubChem CID: 114690) KW - glyceryl trimyristate (PubChem CID: 11148) SP - 361 EP - 70 JF - International journal of pharmaceutics JO - Int J Pharm VL - 506 IS - 1-2 N2 - Taste-masked properties of micropellets based on hard fat and/or solid lipid mixtures (prepared by solvent-free cold extrusion/spheronization), containing metformin hydrochloride were investigated. An in-line and an on-line drug release profile evaluation of the pellets was performed and further correlated with an electronic tongue investigation. The pellets based on more than 30% of lipid binders showed metformin HCl releases below 10% after 30s of dissolution. Micropellets based on 20 and 30% of lipids showed immediate drug release profiles. Likewise, the electronic tongue assay showed a decrease in the sensor responses related to the increase of lipid amount in the formulations denoting a significant improvement in the taste masking properties of pellets based on more than 30% of lipid binders. A slight difference between pellets based on hard fat only and pellets based on ternary lipid mixtures was evidenced. Solvent-free cold extrusion/spheronization using solid lipids showed to be a robust method to obtain high drug loaded metformin HCl micropellets with adequate taste-masked properties and immediate drug release profile. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/27132502/Taste_masking_properties_of_solid_lipid_based_micropellets_obtained_by_cold_extrusion_spheronization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(16)30341-6 DB - PRIME DP - Unbound Medicine ER -