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Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues.
Biochim Biophys Acta. 1989 Apr 25; 991(1):79-84.BB

Abstract

The activity of xanthine dehydrogenase in human postmortem tissues is surprisingly high in brain and heart; activity was found in most tissue samples, whereas many samples contained little or no oxidase activity. We have confirmed the high level of oxidase activity in liver in which tissue conversion of dehydrogenase to oxidase appears complete. We have also confirmed the virtual absence of either activity in fresh human placenta. Fresh rabbit tissues similarly show considerable dehydrogenase activity in brain and heart. In view of the stability and generalised distribution of dehydrogenase activity, our results suggest that some modification of existing ideas on the physiological and pathological roles of the enzyme may be needed.

Authors+Show Affiliations

Division of Inherited Metabolic Diseases, MRC Clinical Research Centre, Harrow U.K.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2713424

Citation

Wajner, M, and R A. Harkness. "Distribution of Xanthine Dehydrogenase and Oxidase Activities in Human and Rabbit Tissues." Biochimica Et Biophysica Acta, vol. 991, no. 1, 1989, pp. 79-84.
Wajner M, Harkness RA. Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues. Biochim Biophys Acta. 1989;991(1):79-84.
Wajner, M., & Harkness, R. A. (1989). Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues. Biochimica Et Biophysica Acta, 991(1), 79-84.
Wajner M, Harkness RA. Distribution of Xanthine Dehydrogenase and Oxidase Activities in Human and Rabbit Tissues. Biochim Biophys Acta. 1989 Apr 25;991(1):79-84. PubMed PMID: 2713424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues. AU - Wajner,M, AU - Harkness,R A, PY - 1989/4/25/pubmed PY - 1989/4/25/medline PY - 1989/4/25/entrez SP - 79 EP - 84 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 991 IS - 1 N2 - The activity of xanthine dehydrogenase in human postmortem tissues is surprisingly high in brain and heart; activity was found in most tissue samples, whereas many samples contained little or no oxidase activity. We have confirmed the high level of oxidase activity in liver in which tissue conversion of dehydrogenase to oxidase appears complete. We have also confirmed the virtual absence of either activity in fresh human placenta. Fresh rabbit tissues similarly show considerable dehydrogenase activity in brain and heart. In view of the stability and generalised distribution of dehydrogenase activity, our results suggest that some modification of existing ideas on the physiological and pathological roles of the enzyme may be needed. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/2713424/Distribution_of_xanthine_dehydrogenase_and_oxidase_activities_in_human_and_rabbit_tissues_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-4165(89)90031-7 DB - PRIME DP - Unbound Medicine ER -