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Clinical Course of Bone Metabolism Disorders in Patients with Inflammatory Bowel Disease: A 5-Year Prospective Study.
Inflamm Bowel Dis. 2016 08; 22(8):1929-36.IB

Abstract

BACKGROUND

The clinical course of bone mineral density (BMD) disorders and the efficacy of treatment of osteopenia and osteoporosis have been poorly studied in patients with inflammatory bowel disease (IBD). The objective was to study the course of BMD disorders in patients with IBD, analyze the factors influencing their development, and assess the effect of treatment with calcium, vitamin D, and bisphosphonates.

METHODS

Consecutive patients with IBD were included and followed up for 5 years. After a baseline densitometry, calcium (1000 mg/d) and vitamin D (800 IU/d) were administered to patients with osteopenia; bisphosphonates to patients with osteoporosis; and patients with normal BMD were only followed-up. After completing the follow-up period, a second densitometry was performed.

RESULTS

One hundred patients were initially included, 60% having a low BMD (44% osteopenia and 16% osteoporosis). Fifty-eight patients completed the follow-up period. At baseline, osteopenia was more frequently found in Crohn's disease than in ulcerative colitis (63% versus 21%, P < 0.05). In patients with normal BMD at baseline, age, smoking habit, and the presence of flares during follow-up were associated with the development of osteopenia. Treatment with calcium and vitamin D improved the hip T-score in patients with osteopenia (-1.03 versus -0.58, P < 0.001) and bisphosphonates provided the same improvement (-1.482 versus -1.072, P < 0.05) in patients with osteoporosis.

CONCLUSIONS

Age, smoking habit, and IBD activity negatively influence the clinical course of BMD. Treatment with calcium and vitamin D improves hip T-score in patients with osteopenia whereas bisphosphonates improve hip T-score in patients with osteoporosis.

Authors+Show Affiliations

Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27135482

Citation

Casals-Seoane, Fernando, et al. "Clinical Course of Bone Metabolism Disorders in Patients With Inflammatory Bowel Disease: a 5-Year Prospective Study." Inflammatory Bowel Diseases, vol. 22, no. 8, 2016, pp. 1929-36.
Casals-Seoane F, Chaparro M, Maté J, et al. Clinical Course of Bone Metabolism Disorders in Patients with Inflammatory Bowel Disease: A 5-Year Prospective Study. Inflamm Bowel Dis. 2016;22(8):1929-36.
Casals-Seoane, F., Chaparro, M., Maté, J., & Gisbert, J. P. (2016). Clinical Course of Bone Metabolism Disorders in Patients with Inflammatory Bowel Disease: A 5-Year Prospective Study. Inflammatory Bowel Diseases, 22(8), 1929-36. https://doi.org/10.1097/MIB.0000000000000815
Casals-Seoane F, et al. Clinical Course of Bone Metabolism Disorders in Patients With Inflammatory Bowel Disease: a 5-Year Prospective Study. Inflamm Bowel Dis. 2016;22(8):1929-36. PubMed PMID: 27135482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Course of Bone Metabolism Disorders in Patients with Inflammatory Bowel Disease: A 5-Year Prospective Study. AU - Casals-Seoane,Fernando, AU - Chaparro,María, AU - Maté,José, AU - Gisbert,Javier P, PY - 2016/5/3/entrez PY - 2016/5/3/pubmed PY - 2018/2/3/medline SP - 1929 EP - 36 JF - Inflammatory bowel diseases JO - Inflamm Bowel Dis VL - 22 IS - 8 N2 - BACKGROUND: The clinical course of bone mineral density (BMD) disorders and the efficacy of treatment of osteopenia and osteoporosis have been poorly studied in patients with inflammatory bowel disease (IBD). The objective was to study the course of BMD disorders in patients with IBD, analyze the factors influencing their development, and assess the effect of treatment with calcium, vitamin D, and bisphosphonates. METHODS: Consecutive patients with IBD were included and followed up for 5 years. After a baseline densitometry, calcium (1000 mg/d) and vitamin D (800 IU/d) were administered to patients with osteopenia; bisphosphonates to patients with osteoporosis; and patients with normal BMD were only followed-up. After completing the follow-up period, a second densitometry was performed. RESULTS: One hundred patients were initially included, 60% having a low BMD (44% osteopenia and 16% osteoporosis). Fifty-eight patients completed the follow-up period. At baseline, osteopenia was more frequently found in Crohn's disease than in ulcerative colitis (63% versus 21%, P < 0.05). In patients with normal BMD at baseline, age, smoking habit, and the presence of flares during follow-up were associated with the development of osteopenia. Treatment with calcium and vitamin D improved the hip T-score in patients with osteopenia (-1.03 versus -0.58, P < 0.001) and bisphosphonates provided the same improvement (-1.482 versus -1.072, P < 0.05) in patients with osteoporosis. CONCLUSIONS: Age, smoking habit, and IBD activity negatively influence the clinical course of BMD. Treatment with calcium and vitamin D improves hip T-score in patients with osteopenia whereas bisphosphonates improve hip T-score in patients with osteoporosis. SN - 1536-4844 UR - https://www.unboundmedicine.com/medline/citation/27135482/Clinical_Course_of_Bone_Metabolism_Disorders_in_Patients_with_Inflammatory_Bowel_Disease:_A_5_Year_Prospective_Study_ L2 - https://academic.oup.com/ibdjournal/article-lookup/doi/10.1097/MIB.0000000000000815 DB - PRIME DP - Unbound Medicine ER -