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The effect of occupational exposure on pro/antioxidant balance in the blood of non-smoking and smoking smelters with diabetes.
Environ Toxicol Pharmacol 2016; 44:99-106ET

Abstract

Arsenic, lead and cadmium, potent environmental toxicants have been reported to induce diabetes mellitus, but their potential biological mechanism(s) have not been much investigated. The present study was designed to correlate parameters of pro/antioxidant balance with occupational exposure on heavy metals and smoking in smelters with diabetes compared on control group. The results showed a significant increase in the concentration of arsenic, cadmium and lead in the blood and urine of smelters, while smoking caused a further increase in the concentration of these metals. Increasing γ-glutamyltransferase activity and lead concentration due to occupational exposure in copper foundry, tobacco smoke and co-existing diabetes were observed. Also these factors have synergistic effects on metallothionein and glutathione concentrations as well as glutathione dependent enzymes activities. Our data suggests that sub-chronic arsenic, lead and cadmium exposure induces diabetic condition which may be mediated due to increased oxidative stress in blood.

Authors+Show Affiliations

Department of Biomedical and Environmental Analysis, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland. Electronic address: a_bizon@op.pl.Professor Emeritus from Department and Clinic of Internal and Occupational Diseases and Hypertension, Wroclaw Medical Uniwersity, Borowska 213, 50-556 Wrocław, Poland.Faculty of Medicine, Wroclaw Medical University, Wrocław, Poland.Department of Biomedical and Environmental Analysis, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.Department of Biomedical and Environmental Analysis, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland. Electronic address: halina.milnerowicz@umed.wroc.pl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27137107

Citation

Bizoń, A, et al. "The Effect of Occupational Exposure On Pro/antioxidant Balance in the Blood of Non-smoking and Smoking Smelters With Diabetes." Environmental Toxicology and Pharmacology, vol. 44, 2016, pp. 99-106.
Bizoń A, Antonowicz-Juchniewicz J, Milnerowicz M, et al. The effect of occupational exposure on pro/antioxidant balance in the blood of non-smoking and smoking smelters with diabetes. Environ Toxicol Pharmacol. 2016;44:99-106.
Bizoń, A., Antonowicz-Juchniewicz, J., Milnerowicz, M., Śliwińska-Mossoń, M., & Milnerowicz, H. (2016). The effect of occupational exposure on pro/antioxidant balance in the blood of non-smoking and smoking smelters with diabetes. Environmental Toxicology and Pharmacology, 44, pp. 99-106. doi:10.1016/j.etap.2016.04.015.
Bizoń A, et al. The Effect of Occupational Exposure On Pro/antioxidant Balance in the Blood of Non-smoking and Smoking Smelters With Diabetes. Environ Toxicol Pharmacol. 2016;44:99-106. PubMed PMID: 27137107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of occupational exposure on pro/antioxidant balance in the blood of non-smoking and smoking smelters with diabetes. AU - Bizoń,A, AU - Antonowicz-Juchniewicz,J, AU - Milnerowicz,M, AU - Śliwińska-Mossoń,M, AU - Milnerowicz,H, Y1 - 2016/04/27/ PY - 2016/02/17/received PY - 2016/04/21/revised PY - 2016/04/26/accepted PY - 2016/5/4/entrez PY - 2016/5/4/pubmed PY - 2017/2/9/medline KW - Diabetes KW - Occupational exposure KW - Pro/antioxidant balance KW - Smelters KW - Smoking SP - 99 EP - 106 JF - Environmental toxicology and pharmacology JO - Environ. Toxicol. Pharmacol. VL - 44 N2 - Arsenic, lead and cadmium, potent environmental toxicants have been reported to induce diabetes mellitus, but their potential biological mechanism(s) have not been much investigated. The present study was designed to correlate parameters of pro/antioxidant balance with occupational exposure on heavy metals and smoking in smelters with diabetes compared on control group. The results showed a significant increase in the concentration of arsenic, cadmium and lead in the blood and urine of smelters, while smoking caused a further increase in the concentration of these metals. Increasing γ-glutamyltransferase activity and lead concentration due to occupational exposure in copper foundry, tobacco smoke and co-existing diabetes were observed. Also these factors have synergistic effects on metallothionein and glutathione concentrations as well as glutathione dependent enzymes activities. Our data suggests that sub-chronic arsenic, lead and cadmium exposure induces diabetic condition which may be mediated due to increased oxidative stress in blood. SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/27137107/The_effect_of_occupational_exposure_on_pro/antioxidant_balance_in_the_blood_of_non_smoking_and_smoking_smelters_with_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(16)30093-X DB - PRIME DP - Unbound Medicine ER -