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Toxicities of glyphosate- and cypermethrin-based pesticides are antagonic in the tenspotted livebearer fish (Cnesterodon decemmaculatus).
Chemosphere. 2016 Jul; 155:429-435.C

Abstract

Although pesticide contamination of surface waters normally occurs in the form of mixtures, the toxicity and interactions displayed by such mixtures have been little characterized until now. The present study examined the interactions prevailing in equitoxic and non-equitoxic binary mixtures of formulations of glyphosate (Glifoglex(®)) and cypermethrin (Glextrin(®)) to the tenspotted livebearer (Cnesterodon decemmaculatus), a widely distributed South American fish. The following 96 h-LC50s were obtained when pesticide formulations were tested individually: Glifoglex(®) 41.4 and 53 mg ae glyphosate/L; Glextrin(®) 1.89 and 2.60 μg cypermethrin/L. Equitoxic and non-equitoxic mixtures were significantly antagonic in all combinations tested. The magnitude of the antagonism (factor by which toxicity differed from concentration addition) varied between 1.37 and 3.09 times in the different non-equitoxic mixtures tested. Antagonism was due to a strong inhibition of cypermethrin toxicity by the glyphosate formulation, the toxicity of the cypermethrin-based pesticide being almost completely overridden by the glyphosate formulation. Results obtained in the current study with fish are radically opposite to those previously observed in tadpoles where synergy was observed when Glifoglex(®) and Glextrin(®) were present in mixtures (Brodeur et al., 2014).

Authors+Show Affiliations

Instituto de Recursos Biológicos, Centro de Investigaciones de Recursos Naturales (CIRN), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina. Electronic address: brodeur.celine@inta.gob.ar.Institut Universitaire de Technologie, Département Génie Biologique, Université Paul Sabatier, Toulouse III, France.Instituto de Recursos Biológicos, Centro de Investigaciones de Recursos Naturales (CIRN), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina.Instituto Tecnología de Alimentos, Centro de Investigación de Agroindustria (CIA), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina.Instituto de Recursos Biológicos, Centro de Investigaciones de Recursos Naturales (CIRN), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina.Instituto de Recursos Biológicos, Centro de Investigaciones de Recursos Naturales (CIRN), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27139121

Citation

Brodeur, Julie Céline, et al. "Toxicities of Glyphosate- and Cypermethrin-based Pesticides Are Antagonic in the Tenspotted Livebearer Fish (Cnesterodon Decemmaculatus)." Chemosphere, vol. 155, 2016, pp. 429-435.
Brodeur JC, Malpel S, Anglesio AB, et al. Toxicities of glyphosate- and cypermethrin-based pesticides are antagonic in the tenspotted livebearer fish (Cnesterodon decemmaculatus). Chemosphere. 2016;155:429-435.
Brodeur, J. C., Malpel, S., Anglesio, A. B., Cristos, D., D'Andrea, M. F., & Poliserpi, M. B. (2016). Toxicities of glyphosate- and cypermethrin-based pesticides are antagonic in the tenspotted livebearer fish (Cnesterodon decemmaculatus). Chemosphere, 155, 429-435. https://doi.org/10.1016/j.chemosphere.2016.04.075
Brodeur JC, et al. Toxicities of Glyphosate- and Cypermethrin-based Pesticides Are Antagonic in the Tenspotted Livebearer Fish (Cnesterodon Decemmaculatus). Chemosphere. 2016;155:429-435. PubMed PMID: 27139121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicities of glyphosate- and cypermethrin-based pesticides are antagonic in the tenspotted livebearer fish (Cnesterodon decemmaculatus). AU - Brodeur,Julie Céline, AU - Malpel,Solène, AU - Anglesio,Ana Belén, AU - Cristos,Diego, AU - D'Andrea,María Florencia, AU - Poliserpi,María Belén, Y1 - 2016/04/30/ PY - 2016/02/23/received PY - 2016/04/19/revised PY - 2016/04/20/accepted PY - 2016/5/4/entrez PY - 2016/5/4/pubmed PY - 2017/3/17/medline KW - Amphibian KW - Cypermethrin KW - Fish KW - Glyphosate KW - Mixtures KW - Pesticides SP - 429 EP - 435 JF - Chemosphere JO - Chemosphere VL - 155 N2 - Although pesticide contamination of surface waters normally occurs in the form of mixtures, the toxicity and interactions displayed by such mixtures have been little characterized until now. The present study examined the interactions prevailing in equitoxic and non-equitoxic binary mixtures of formulations of glyphosate (Glifoglex(®)) and cypermethrin (Glextrin(®)) to the tenspotted livebearer (Cnesterodon decemmaculatus), a widely distributed South American fish. The following 96 h-LC50s were obtained when pesticide formulations were tested individually: Glifoglex(®) 41.4 and 53 mg ae glyphosate/L; Glextrin(®) 1.89 and 2.60 μg cypermethrin/L. Equitoxic and non-equitoxic mixtures were significantly antagonic in all combinations tested. The magnitude of the antagonism (factor by which toxicity differed from concentration addition) varied between 1.37 and 3.09 times in the different non-equitoxic mixtures tested. Antagonism was due to a strong inhibition of cypermethrin toxicity by the glyphosate formulation, the toxicity of the cypermethrin-based pesticide being almost completely overridden by the glyphosate formulation. Results obtained in the current study with fish are radically opposite to those previously observed in tadpoles where synergy was observed when Glifoglex(®) and Glextrin(®) were present in mixtures (Brodeur et al., 2014). SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/27139121/Toxicities_of_glyphosate__and_cypermethrin_based_pesticides_are_antagonic_in_the_tenspotted_livebearer_fish__Cnesterodon_decemmaculatus__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(16)30561-6 DB - PRIME DP - Unbound Medicine ER -