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Effects of neurostimulation for advanced Parkinson's disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials.
Sci Rep. 2016 05 04; 6:25285.SR

Abstract

Deep brain stimulation (DBS) is the surgical procedure of choice for patients with advanced Parkinson disease (PD). We aim to evaluate the efficacy of GPi (globus pallidus internus), STN (subthalamic nucleus)-DBS and medical therapy for PD. We conducted a systematic review and multiple-treatments meta-analysis to investigate the efficacy of neurostimulation and medical therapy for PD patients. Sixteen eligible studies were included in this analysis. We pooled the whole data and found obvious difference between GPi-DBS versus medical therapy and STN-DBS versus medical therapy in terms of UPDRS scores (Unified Parkinson's Disease Rating Scale). Meanwhile, we found GPi-DBS had the similar efficacy on the UPDRS scores when compared with STN-DBS. What is more, quality of life, measured by PDQ-39 (Parkinson's disease Questionnaire) showed greater improvement after GPi-DBS than STN-DBS. Five studies showed STN-DBS was more effective for reduction in medication than GPi-DBS. Overall, either GPi-DBS or STN-DBS was an effective technique to control PD patients' symptoms and improved their functionality and quality of life. Meanwhile, the UPDRS scores measuring parkinsonian symptoms revealed no significant difference between GPi-DBS and STN-DBS. STN-DBS was more effective for reduction in medication than GPi-DBS. Alternatively, GPi-DBS was more effective for improving the PDQ-39 score than STN-DBS.

Authors+Show Affiliations

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.The center of Traditional Chinese Medicine, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.The center of Traditional Chinese Medicine, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.The center of Traditional Chinese Medicine, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.The center of Traditional Chinese Medicine, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27142183

Citation

Xie, Cheng-Long, et al. "Effects of Neurostimulation for Advanced Parkinson's Disease Patients On Motor Symptoms: a Multiple-treatments Meta-analysas of Randomized Controlled Trials." Scientific Reports, vol. 6, 2016, p. 25285.
Xie CL, Shao B, Chen J, et al. Effects of neurostimulation for advanced Parkinson's disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials. Sci Rep. 2016;6:25285.
Xie, C. L., Shao, B., Chen, J., Zhou, Y., Lin, S. Y., & Wang, W. W. (2016). Effects of neurostimulation for advanced Parkinson's disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials. Scientific Reports, 6, 25285. https://doi.org/10.1038/srep25285
Xie CL, et al. Effects of Neurostimulation for Advanced Parkinson's Disease Patients On Motor Symptoms: a Multiple-treatments Meta-analysas of Randomized Controlled Trials. Sci Rep. 2016 05 4;6:25285. PubMed PMID: 27142183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of neurostimulation for advanced Parkinson's disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials. AU - Xie,Cheng-Long, AU - Shao,Bei, AU - Chen,Jie, AU - Zhou,Yi, AU - Lin,Shi-Yi, AU - Wang,Wen-Wen, Y1 - 2016/05/04/ PY - 2015/11/06/received PY - 2016/04/14/accepted PY - 2016/5/5/entrez PY - 2016/5/5/pubmed PY - 2018/1/26/medline SP - 25285 EP - 25285 JF - Scientific reports JO - Sci Rep VL - 6 N2 - Deep brain stimulation (DBS) is the surgical procedure of choice for patients with advanced Parkinson disease (PD). We aim to evaluate the efficacy of GPi (globus pallidus internus), STN (subthalamic nucleus)-DBS and medical therapy for PD. We conducted a systematic review and multiple-treatments meta-analysis to investigate the efficacy of neurostimulation and medical therapy for PD patients. Sixteen eligible studies were included in this analysis. We pooled the whole data and found obvious difference between GPi-DBS versus medical therapy and STN-DBS versus medical therapy in terms of UPDRS scores (Unified Parkinson's Disease Rating Scale). Meanwhile, we found GPi-DBS had the similar efficacy on the UPDRS scores when compared with STN-DBS. What is more, quality of life, measured by PDQ-39 (Parkinson's disease Questionnaire) showed greater improvement after GPi-DBS than STN-DBS. Five studies showed STN-DBS was more effective for reduction in medication than GPi-DBS. Overall, either GPi-DBS or STN-DBS was an effective technique to control PD patients' symptoms and improved their functionality and quality of life. Meanwhile, the UPDRS scores measuring parkinsonian symptoms revealed no significant difference between GPi-DBS and STN-DBS. STN-DBS was more effective for reduction in medication than GPi-DBS. Alternatively, GPi-DBS was more effective for improving the PDQ-39 score than STN-DBS. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/27142183/Effects_of_neurostimulation_for_advanced_Parkinson's_disease_patients_on_motor_symptoms:_A_multiple_treatments_meta_analysas_of_randomized_controlled_trials_ L2 - https://doi.org/10.1038/srep25285 DB - PRIME DP - Unbound Medicine ER -