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Stone formation and urine composition in calcium stone formers without medical treatment.
Eur Urol 1989; 16(2):144-50EU

Abstract

A retrospective estimate of the annual rate of stone formation (fSF) was obtained in only 154 (35%) of 438 patients without medical treatment at our out-patient stone clinic. Eighty-three of these patients had never been on any prophylactic treatment and were only given advice concerning drinking and dietary habits. There was a high calcium excretion in 46%, high oxalate in 17%, low citrate in 11%, low magnesium in 17%, and increased urate in 16% of the patients. As much as 25% had a 24-hour urine volume below 1,000 ml. There was a good correspondence between stone formation during the follow-up period (tT) and a period of the same length following diagnosis (tA). The mean (+/- SD) tT was 3.2 +/- 1.9 years, with an fSF of 0.19 +/- 0.43. During the tA period fSF was 0.13 +/- 0.31. The number of patients who formed new stones during these periods were 21 and 22, respectively. It is suggested that stone formation during tT and tA advantageously might be used for preliminary evaluation of the therapeutic response. The risk of forming a urine highly supersaturated with calcium oxalate was expressed in terms of a standardized AP(CaOx) index calculated for a 24-hour urine volume of 1,500 ml. There was no relationship between this AP(CaOx) index and fSF. When only those patients were considered who formed new stones during the first 10 years after diagnosis, slightly higher values of the standardized AP(CaOx) index were recorded than in the recurrence-free group.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Urology, University Hospital, Linköping, Sweden.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2714332

Citation

Bek-Jensen, H, and H G. Tiselius. "Stone Formation and Urine Composition in Calcium Stone Formers Without Medical Treatment." European Urology, vol. 16, no. 2, 1989, pp. 144-50.
Bek-Jensen H, Tiselius HG. Stone formation and urine composition in calcium stone formers without medical treatment. Eur Urol. 1989;16(2):144-50.
Bek-Jensen, H., & Tiselius, H. G. (1989). Stone formation and urine composition in calcium stone formers without medical treatment. European Urology, 16(2), pp. 144-50.
Bek-Jensen H, Tiselius HG. Stone Formation and Urine Composition in Calcium Stone Formers Without Medical Treatment. Eur Urol. 1989;16(2):144-50. PubMed PMID: 2714332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stone formation and urine composition in calcium stone formers without medical treatment. AU - Bek-Jensen,H, AU - Tiselius,H G, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 144 EP - 50 JF - European urology JO - Eur. Urol. VL - 16 IS - 2 N2 - A retrospective estimate of the annual rate of stone formation (fSF) was obtained in only 154 (35%) of 438 patients without medical treatment at our out-patient stone clinic. Eighty-three of these patients had never been on any prophylactic treatment and were only given advice concerning drinking and dietary habits. There was a high calcium excretion in 46%, high oxalate in 17%, low citrate in 11%, low magnesium in 17%, and increased urate in 16% of the patients. As much as 25% had a 24-hour urine volume below 1,000 ml. There was a good correspondence between stone formation during the follow-up period (tT) and a period of the same length following diagnosis (tA). The mean (+/- SD) tT was 3.2 +/- 1.9 years, with an fSF of 0.19 +/- 0.43. During the tA period fSF was 0.13 +/- 0.31. The number of patients who formed new stones during these periods were 21 and 22, respectively. It is suggested that stone formation during tT and tA advantageously might be used for preliminary evaluation of the therapeutic response. The risk of forming a urine highly supersaturated with calcium oxalate was expressed in terms of a standardized AP(CaOx) index calculated for a 24-hour urine volume of 1,500 ml. There was no relationship between this AP(CaOx) index and fSF. When only those patients were considered who formed new stones during the first 10 years after diagnosis, slightly higher values of the standardized AP(CaOx) index were recorded than in the recurrence-free group.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0302-2838 UR - https://www.unboundmedicine.com/medline/citation/2714332/Stone_formation_and_urine_composition_in_calcium_stone_formers_without_medical_treatment_ DB - PRIME DP - Unbound Medicine ER -