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Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus.
Clin Interv Aging. 2016; 11:445-52.CI

Abstract

OBJECTIVE

People with type 2 diabetes are at an increased risk of hypertension, arteriosclerosis, heart disease, and stroke. Glucose intolerance (insulin resistance) is the main feature of type 2 diabetes. Obesity leads to insulin resistance, dyslipidemia, etc. The aim of this study was to assess the biochemical parameters and measures of obesity in type 2 diabetes mellitus (T2DM).

METHODS

A total of 2,273 males and 6,547 females previously healthy volunteers (aged 41-95 years old) were recruited by open invitation. The basic information, including age, sex, height, weight, body mass index (BMI), waistline, hipline, menstrual cycle, and medical history, was collected by questionnaire survey and physical examination. Serum lipid profile, liver transaminase, blood glucose, postprandial blood glucose, and hemoglobin A1c were obtained after 12 hours of fasting.

RESULTS

According to our results, diabetic patients presented serum lipid abnormality. Elevated triglyceride (TG) levels (≥1.7 mmol/L) were noted in 19.69% of males and 20.40% of females, and reduced high-density lipoprotein cholesterol (HDL-C) levels (≤1.15 mmol/L) were noted in 21.96% of males and 15.74% of females. The combination of elevated TG and reduced HDL-C was the most prevalent of the combined lipid abnormalities. In contrast, no differences were observed in the levels of low-density lipoprotein cholesterol and total cholesterol. Moreover, there were statistically significant differences in the levels of BMI and waistline between T2DM and non-T2DM participants. After adjustment for BMI, logistic regression analysis revealed that the subjects with BMI ≤20 kg/m(2) and >30 kg/m(2) had a significantly elevated hazard ratio of T2DM compared with participants having a BMI range of 20-30 kg/m(2) in both males and females. However, there was a significant difference between T2DM patients and non-T2DM patients in waistline (χ (2)=8.57, P<0.001) than in BMI parameter (χ (2)=6.29, P<0.001).

CONCLUSION

The present study shows for the first time that low levels of HDL-C, high levels of TG, and abnormal levels in BMI and waistline increase the risk of type 2 T2DM in Chinese people.

Authors+Show Affiliations

Surgical Research, Department of Orthopedic and Trauma Surgery, Duisburg-Essen University Hospital, Essen, Germany.Department of Orthopedics, Dalian Central Hospital, Dalian, People's Republic of China.Department of Orthopedics, Dalian Central Hospital, Dalian, People's Republic of China.Department of Orthopedics, Dalian Central Hospital, Dalian, People's Republic of China.Department of Orthopedics, Dalian Central Hospital, Dalian, People's Republic of China.Department of Gastroenterology, Shandong Provincial Hospital, Jinan, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27143868

Citation

Cui, Rongtao, et al. "Evaluation of Serum Lipid Profile, Body Mass Index, and Waistline in Chinese Patients With Type 2 Diabetes Mellitus." Clinical Interventions in Aging, vol. 11, 2016, pp. 445-52.
Cui R, Qi Z, Zhou L, et al. Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus. Clin Interv Aging. 2016;11:445-52.
Cui, R., Qi, Z., Zhou, L., Li, Z., Li, Q., & Zhang, J. (2016). Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus. Clinical Interventions in Aging, 11, 445-52. https://doi.org/10.2147/CIA.S104803
Cui R, et al. Evaluation of Serum Lipid Profile, Body Mass Index, and Waistline in Chinese Patients With Type 2 Diabetes Mellitus. Clin Interv Aging. 2016;11:445-52. PubMed PMID: 27143868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus. AU - Cui,Rongtao, AU - Qi,Zhiming, AU - Zhou,Lin, AU - Li,Zuohong, AU - Li,Qing, AU - Zhang,Junyong, Y1 - 2016/04/18/ PY - 2016/5/5/entrez PY - 2016/5/5/pubmed PY - 2017/2/7/medline KW - HDL-C KW - T2DM KW - TG KW - body mass index KW - risk assessment KW - waistline SP - 445 EP - 52 JF - Clinical interventions in aging JO - Clin Interv Aging VL - 11 N2 - OBJECTIVE: People with type 2 diabetes are at an increased risk of hypertension, arteriosclerosis, heart disease, and stroke. Glucose intolerance (insulin resistance) is the main feature of type 2 diabetes. Obesity leads to insulin resistance, dyslipidemia, etc. The aim of this study was to assess the biochemical parameters and measures of obesity in type 2 diabetes mellitus (T2DM). METHODS: A total of 2,273 males and 6,547 females previously healthy volunteers (aged 41-95 years old) were recruited by open invitation. The basic information, including age, sex, height, weight, body mass index (BMI), waistline, hipline, menstrual cycle, and medical history, was collected by questionnaire survey and physical examination. Serum lipid profile, liver transaminase, blood glucose, postprandial blood glucose, and hemoglobin A1c were obtained after 12 hours of fasting. RESULTS: According to our results, diabetic patients presented serum lipid abnormality. Elevated triglyceride (TG) levels (≥1.7 mmol/L) were noted in 19.69% of males and 20.40% of females, and reduced high-density lipoprotein cholesterol (HDL-C) levels (≤1.15 mmol/L) were noted in 21.96% of males and 15.74% of females. The combination of elevated TG and reduced HDL-C was the most prevalent of the combined lipid abnormalities. In contrast, no differences were observed in the levels of low-density lipoprotein cholesterol and total cholesterol. Moreover, there were statistically significant differences in the levels of BMI and waistline between T2DM and non-T2DM participants. After adjustment for BMI, logistic regression analysis revealed that the subjects with BMI ≤20 kg/m(2) and >30 kg/m(2) had a significantly elevated hazard ratio of T2DM compared with participants having a BMI range of 20-30 kg/m(2) in both males and females. However, there was a significant difference between T2DM patients and non-T2DM patients in waistline (χ (2)=8.57, P<0.001) than in BMI parameter (χ (2)=6.29, P<0.001). CONCLUSION: The present study shows for the first time that low levels of HDL-C, high levels of TG, and abnormal levels in BMI and waistline increase the risk of type 2 T2DM in Chinese people. SN - 1178-1998 UR - https://www.unboundmedicine.com/medline/citation/27143868/Evaluation_of_serum_lipid_profile_body_mass_index_and_waistline_in_Chinese_patients_with_type_2_diabetes_mellitus_ L2 - https://dx.doi.org/10.2147/CIA.S104803 DB - PRIME DP - Unbound Medicine ER -