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Retrospective evaluation of the effects of administration of tetrastarch (hydroxyethyl starch 130/0.4) on plasma creatinine concentration in dogs (2010-2013): 201 dogs.

Abstract

OBJECTIVE

To determine changes in creatinine concentrations following the administration of 6% tetrastarch (hydroxyethyl starch [HES] 130/0.4) compared to crystalloids (CRYSs) in critically ill dogs.

DESIGN

Retrospective case series (2010-2013).

SETTING

University teaching hospital.

ANIMALS

Two hundred and one dogs admitted to the intensive care unit with initial plasma creatinine concentrations not exceeding laboratory reference intervals (52-117 μmol/L [0.6-1.3 mg/dL]) and receiving either CRYSs alone (CRYS group, n = 115) or HES with or without CRYSs (HES group, n = 86) for at least 24 hours.

INTERVENTIONS

None.

MEASUREMENTS AND MAIN RESULTS

Creatinine concentrations at admission to the intensive care unit (T0), and 2-13 days (T1) and 2-12 weeks (T2) after initiation of fluid therapy were analyzed. Creatinine concentrations were analyzed as absolute values and as the maximum percentage change from T0 to T1 (T1max%) and from T0 to T2 (T2max%), respectively. Creatinine concentrations were available for 192 dogs during T1 and 37 dogs during T2. The median cumulative dose of HES was 86 mL/kg (range, 12-336 mL/kg). No difference was detected between the groups for age, gender, body weight, and length of hospitalization. Outcome was significantly different between the HES (66% survived) and the CRYS (87% survived) groups (P = 0.014). No significant difference was detected between groups for creatinine concentrations at T0, T1, T2, T1max%, or T2max%. No significant difference was detected between the groups for T1max% creatinine in dogs subclassified as having systemic inflammatory response syndrome or sepsis.

CONCLUSIONS

HES administration in this canine population did not result in increased creatinine concentrations compared to administration of CRYSs. Further studies are needed to establish the safety of HES in critically ill dogs.

Authors+Show Affiliations

Emergency and Critical Care Section, Small Animal Clinic, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Laenggassstrasse 124, 3012 Bern, Switzerland.Diagnostic Clinical Laboratory, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Laenggassstrasse 124, 3012 Bern, Switzerland.Emergency and Critical Care Section, Small Animal Clinic, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Laenggassstrasse 124, 3012 Bern, Switzerland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27144501

Citation

Yozova, Ivayla D., et al. "Retrospective Evaluation of the Effects of Administration of Tetrastarch (hydroxyethyl Starch 130/0.4) On Plasma Creatinine Concentration in Dogs (2010-2013): 201 Dogs." Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), vol. 26, no. 4, 2016, pp. 568-77.
Yozova ID, Howard J, Adamik KN. Retrospective evaluation of the effects of administration of tetrastarch (hydroxyethyl starch 130/0.4) on plasma creatinine concentration in dogs (2010-2013): 201 dogs. J Vet Emerg Crit Care (San Antonio). 2016;26(4):568-77.
Yozova, I. D., Howard, J., & Adamik, K. N. (2016). Retrospective evaluation of the effects of administration of tetrastarch (hydroxyethyl starch 130/0.4) on plasma creatinine concentration in dogs (2010-2013): 201 dogs. Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), 26(4), pp. 568-77. doi:10.1111/vec.12483.
Yozova ID, Howard J, Adamik KN. Retrospective Evaluation of the Effects of Administration of Tetrastarch (hydroxyethyl Starch 130/0.4) On Plasma Creatinine Concentration in Dogs (2010-2013): 201 Dogs. J Vet Emerg Crit Care (San Antonio). 2016;26(4):568-77. PubMed PMID: 27144501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective evaluation of the effects of administration of tetrastarch (hydroxyethyl starch 130/0.4) on plasma creatinine concentration in dogs (2010-2013): 201 dogs. AU - Yozova,Ivayla D, AU - Howard,Judith, AU - Adamik,Katja-Nicole, Y1 - 2016/05/03/ PY - 2015/03/05/received PY - 2015/08/12/revised PY - 2015/08/27/accepted PY - 2016/5/5/entrez PY - 2016/5/5/pubmed PY - 2017/5/10/medline KW - acute kidney injury KW - canine KW - fluid therapy KW - hydroxyethyl starch KW - mortality SP - 568 EP - 77 JF - Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) JO - J Vet Emerg Crit Care (San Antonio) VL - 26 IS - 4 N2 - OBJECTIVE: To determine changes in creatinine concentrations following the administration of 6% tetrastarch (hydroxyethyl starch [HES] 130/0.4) compared to crystalloids (CRYSs) in critically ill dogs. DESIGN: Retrospective case series (2010-2013). SETTING: University teaching hospital. ANIMALS: Two hundred and one dogs admitted to the intensive care unit with initial plasma creatinine concentrations not exceeding laboratory reference intervals (52-117 μmol/L [0.6-1.3 mg/dL]) and receiving either CRYSs alone (CRYS group, n = 115) or HES with or without CRYSs (HES group, n = 86) for at least 24 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Creatinine concentrations at admission to the intensive care unit (T0), and 2-13 days (T1) and 2-12 weeks (T2) after initiation of fluid therapy were analyzed. Creatinine concentrations were analyzed as absolute values and as the maximum percentage change from T0 to T1 (T1max%) and from T0 to T2 (T2max%), respectively. Creatinine concentrations were available for 192 dogs during T1 and 37 dogs during T2. The median cumulative dose of HES was 86 mL/kg (range, 12-336 mL/kg). No difference was detected between the groups for age, gender, body weight, and length of hospitalization. Outcome was significantly different between the HES (66% survived) and the CRYS (87% survived) groups (P = 0.014). No significant difference was detected between groups for creatinine concentrations at T0, T1, T2, T1max%, or T2max%. No significant difference was detected between the groups for T1max% creatinine in dogs subclassified as having systemic inflammatory response syndrome or sepsis. CONCLUSIONS: HES administration in this canine population did not result in increased creatinine concentrations compared to administration of CRYSs. Further studies are needed to establish the safety of HES in critically ill dogs. SN - 1476-4431 UR - https://www.unboundmedicine.com/medline/citation/27144501/Retrospective_evaluation_of_the_effects_of_administration_of_tetrastarch__hydroxyethyl_starch_130/0_4__on_plasma_creatinine_concentration_in_dogs__2010_2013_:_201_dogs_ L2 - https://doi.org/10.1111/vec.12483 DB - PRIME DP - Unbound Medicine ER -