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Maternal vitamin D status and childhood asthma, wheeze, and eczema: A systematic review and meta-analysis.
Pediatr Allergy Immunol. 2016 09; 27(6):612-9.PA

Abstract

BACKGROUND

Maternal vitamin D status has been reported to be associated with childhood allergic diseases. However, this association remains to be fully elucidated.

METHODS

A systematic review and meta-analysis was conducted using prospective cohort studies that examined the association between maternal vitamin D status and childhood allergic diseases including wheeze, eczema and asthma. We searched electronic databases of PubMed, EMBASE, the Cochrane library, the Wanfang (Chinese) database, the VIP (Chinese) database, and Chinese National Knowledge Infrastructure (CNKI) up to August 2014. Odds ratios and 95% confidence intervals (CIs) from individual studies were synthesized using a fixed effects model.

RESULTS

Four studies on the association between maternal vitamin D status and childhood asthma (3666 mother-child pairs), four studies on the association between maternal vitamin D status and childhood wheeze (2225 mother-child pairs) and three papers on the association between maternal vitamin D status and childhood eczema (2172 mother-child pairs) met our inclusion criteria. Maternal vitamin D status during pregnancy was associated with childhood eczema (pooled OR=0.904, 95% CI=0.831-0.983). However, the meta-analysis showed no statistical association between maternal vitamin D status and childhood asthma (pooled OR=0.981, 95% CI=0.944-1.019) or childhood wheeze (pooled OR=0.995, 95% CI=0.982-1.009).

CONCLUSIONS

Our meta-analysis found that lower maternal vitamin D during pregnancy was associated with an increased risk of childhood eczema but was not associated with childhood asthma or wheeze. The role of maternal vitamin D as an important protective factor for the development of childhood eczema remains to be elucidated.

Authors+Show Affiliations

MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27145360

Citation

Wei, Zhenzhen, et al. "Maternal Vitamin D Status and Childhood Asthma, Wheeze, and Eczema: a Systematic Review and Meta-analysis." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 27, no. 6, 2016, pp. 612-9.
Wei Z, Zhang J, Yu X. Maternal vitamin D status and childhood asthma, wheeze, and eczema: A systematic review and meta-analysis. Pediatr Allergy Immunol. 2016;27(6):612-9.
Wei, Z., Zhang, J., & Yu, X. (2016). Maternal vitamin D status and childhood asthma, wheeze, and eczema: A systematic review and meta-analysis. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 27(6), 612-9. https://doi.org/10.1111/pai.12593
Wei Z, Zhang J, Yu X. Maternal Vitamin D Status and Childhood Asthma, Wheeze, and Eczema: a Systematic Review and Meta-analysis. Pediatr Allergy Immunol. 2016;27(6):612-9. PubMed PMID: 27145360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal vitamin D status and childhood asthma, wheeze, and eczema: A systematic review and meta-analysis. AU - Wei,Zhenzhen, AU - Zhang,Jun, AU - Yu,Xiaodan, Y1 - 2016/07/20/ PY - 2016/04/29/accepted PY - 2016/5/5/entrez PY - 2016/5/5/pubmed PY - 2018/1/5/medline KW - allergy KW - childhood KW - maternal KW - vitamin D SP - 612 EP - 9 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 27 IS - 6 N2 - BACKGROUND: Maternal vitamin D status has been reported to be associated with childhood allergic diseases. However, this association remains to be fully elucidated. METHODS: A systematic review and meta-analysis was conducted using prospective cohort studies that examined the association between maternal vitamin D status and childhood allergic diseases including wheeze, eczema and asthma. We searched electronic databases of PubMed, EMBASE, the Cochrane library, the Wanfang (Chinese) database, the VIP (Chinese) database, and Chinese National Knowledge Infrastructure (CNKI) up to August 2014. Odds ratios and 95% confidence intervals (CIs) from individual studies were synthesized using a fixed effects model. RESULTS: Four studies on the association between maternal vitamin D status and childhood asthma (3666 mother-child pairs), four studies on the association between maternal vitamin D status and childhood wheeze (2225 mother-child pairs) and three papers on the association between maternal vitamin D status and childhood eczema (2172 mother-child pairs) met our inclusion criteria. Maternal vitamin D status during pregnancy was associated with childhood eczema (pooled OR=0.904, 95% CI=0.831-0.983). However, the meta-analysis showed no statistical association between maternal vitamin D status and childhood asthma (pooled OR=0.981, 95% CI=0.944-1.019) or childhood wheeze (pooled OR=0.995, 95% CI=0.982-1.009). CONCLUSIONS: Our meta-analysis found that lower maternal vitamin D during pregnancy was associated with an increased risk of childhood eczema but was not associated with childhood asthma or wheeze. The role of maternal vitamin D as an important protective factor for the development of childhood eczema remains to be elucidated. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/27145360/Maternal_vitamin_D_status_and_childhood_asthma_wheeze_and_eczema:_A_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1111/pai.12593 DB - PRIME DP - Unbound Medicine ER -