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Functional connectivity underpinnings of fatigue in "Drug-Naïve" patients with Parkinson's disease.
Mov Disord. 2016 10; 31(10):1497-1505.MD

Abstract

INTRODUCTION

Fatigue is a common problem in PD either in the early or later stage of the disease. Using resting-state functional MRI, we investigated the functional correlates of fatigue in a cohort of "drug-naïve" patients with PD.

METHODS

MRI at 3Tesla was collected in 40 patients with PD, 20 with and 20 without fatigue, and 20 matched healthy controls. Presence and the severity of fatigue were defined based on the 16-item Parkinson fatigue scale. Single-subject and group-level independent component analysis was used to investigate functional connectivity differences within the major resting state networks between patients subgroups and healthy controls. In addition, we used voxel-based morphometry to test whether between-group functional changes were related to structural differences.

RESULTS

Distressing fatigue was associated with a decreased connectivity in the supplementary motor area within the sensorimotor network and an increased connectivity in the prefrontal and posterior cingulate cortices within the default mode network (P < 0.05 corrected). Fatigue severity was correlated with both sensorimotor and default mode networks connectivity changes. Voxel-based morphometry analysis did not reveal any significant volume differences between all patients with PD and healthy controls and between patients with PD with and without fatigue (P < 0.05; family-wise error).

CONCLUSIONS

Our findings revealed that primary PD-related fatigue is associated with an altered default mode network and sensorimotor network connectivity in drug-naïve patients. We hypothesize that these divergent motor and cognitive networks connectivity changes and their adaptive or maladaptive functional outcome may play a prominent role in the pathophysiology of fatigue in PD. © 2016 International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy. alessandro.tessitore@unina2.it.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy. IDC Hermitage Capodimonte, Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.Neuroradiology Service, Second University of Naples, Naples, Italy.Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno, Italy. Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27145402

Citation

Tessitore, Alessandro, et al. "Functional Connectivity Underpinnings of Fatigue in "Drug-Naïve" Patients With Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 31, no. 10, 2016, pp. 1497-1505.
Tessitore A, Giordano A, De Micco R, et al. Functional connectivity underpinnings of fatigue in "Drug-Naïve" patients with Parkinson's disease. Mov Disord. 2016;31(10):1497-1505.
Tessitore, A., Giordano, A., De Micco, R., Caiazzo, G., Russo, A., Cirillo, M., Esposito, F., & Tedeschi, G. (2016). Functional connectivity underpinnings of fatigue in "Drug-Naïve" patients with Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 31(10), 1497-1505. https://doi.org/10.1002/mds.26650
Tessitore A, et al. Functional Connectivity Underpinnings of Fatigue in "Drug-Naïve" Patients With Parkinson's Disease. Mov Disord. 2016;31(10):1497-1505. PubMed PMID: 27145402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional connectivity underpinnings of fatigue in "Drug-Naïve" patients with Parkinson's disease. AU - Tessitore,Alessandro, AU - Giordano,Alfonso, AU - De Micco,Rosa, AU - Caiazzo,Giuseppina, AU - Russo,Antonio, AU - Cirillo,Mario, AU - Esposito,Fabrizio, AU - Tedeschi,Gioacchino, PY - 2015/07/09/received PY - 2016/03/13/revised PY - 2016/03/16/accepted PY - 2016/5/5/pubmed PY - 2017/12/28/medline PY - 2016/5/5/entrez KW - early-stage Parkinson's disease KW - fatigue KW - functional connectivity KW - resting state networks SP - 1497 EP - 1505 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 31 IS - 10 N2 - INTRODUCTION: Fatigue is a common problem in PD either in the early or later stage of the disease. Using resting-state functional MRI, we investigated the functional correlates of fatigue in a cohort of "drug-naïve" patients with PD. METHODS: MRI at 3Tesla was collected in 40 patients with PD, 20 with and 20 without fatigue, and 20 matched healthy controls. Presence and the severity of fatigue were defined based on the 16-item Parkinson fatigue scale. Single-subject and group-level independent component analysis was used to investigate functional connectivity differences within the major resting state networks between patients subgroups and healthy controls. In addition, we used voxel-based morphometry to test whether between-group functional changes were related to structural differences. RESULTS: Distressing fatigue was associated with a decreased connectivity in the supplementary motor area within the sensorimotor network and an increased connectivity in the prefrontal and posterior cingulate cortices within the default mode network (P < 0.05 corrected). Fatigue severity was correlated with both sensorimotor and default mode networks connectivity changes. Voxel-based morphometry analysis did not reveal any significant volume differences between all patients with PD and healthy controls and between patients with PD with and without fatigue (P < 0.05; family-wise error). CONCLUSIONS: Our findings revealed that primary PD-related fatigue is associated with an altered default mode network and sensorimotor network connectivity in drug-naïve patients. We hypothesize that these divergent motor and cognitive networks connectivity changes and their adaptive or maladaptive functional outcome may play a prominent role in the pathophysiology of fatigue in PD. © 2016 International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/27145402/Functional_connectivity_underpinnings_of_fatigue_in_"Drug_Naïve"_patients_with_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.26650 DB - PRIME DP - Unbound Medicine ER -