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Adjuvant Treatment with Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: A Meta-analysis of Randomized Controlled Trials.
Phytother Res. 2016 Jul; 30(7):1095-103.PR

Abstract

This meta-analysis aimed to evaluate the immunomodulating function of Yupingfeng Formula (YPFF) in children with recurrent respiratory tract infections (RRTIs). The PubMed, EMBASE, Cochrane Library, CNKI and WanFang databases were searched for randomized controlled trials comparing with and without YPFF for RRTIs in children. Twelve trials with 1236 patients were identified. Adjuvant treatment with YPFF significantly increased serum levels of IgA (weighted mean difference [WMD] 0.33 mg/mL; 95% confidence interval [CI] 0.20 to 0.45), IgG (WMD 1.36 mg/mL; 95% CI 1.06 to 1.65), IgM (WMD 0.16 mg/mL; 95% CI 0.02 to 0.31), and CD3(+) T-lymphocytes (WMD 10.16%; 95% CI 4.62 to 15.69) but not CD4(+) T-lymphocytes (WMD 3.16%; 95% CI -0.27 to 6.59) and CD8(+) T-lymphocytes (WMD -0.84%; 95% CI -2.50 to 0.81). YPFF also reduced the frequency of RRTIs (WMD -3.80 times; 95% CI -4.86 to -2.74) and increased total effective rates of symptom improvement (risk ratio: 1.44; 95% CI 1.19 to 1.75). Adjuvant treatment with YPFF could improve total clinical effective rate and decrease the frequency of respiratory tract infections in children with RRTIs. The beneficial effects of YPFF may be correlated to its immunomodulating action. More well-designed trials with larger sample sizes are needed to evaluate its efficacy and safety. Copyright © 2016 John Wiley & Sons, Ltd.

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Authors+Show Affiliations

Song T
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Hou X
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Yu X
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Wang Z
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Wang R
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Li Y
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Hu D
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Wang X
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Xiao Z
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Sui Y
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Zhu C
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Wang J
Department of Pediatrics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.

MeSH

ChildDrugs, Chinese HerbalHumansImmunologic FactorsRandomized Controlled Trials as TopicRecurrenceRespiratory Tract Infections

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

27145435

Citation

Song, Tao, et al. "Adjuvant Treatment With Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: a Meta-analysis of Randomized Controlled Trials." Phytotherapy Research : PTR, vol. 30, no. 7, 2016, pp. 1095-103.
Song T, Hou X, Yu X, et al. Adjuvant Treatment with Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: A Meta-analysis of Randomized Controlled Trials. Phytother Res. 2016;30(7):1095-103.
Song, T., Hou, X., Yu, X., Wang, Z., Wang, R., Li, Y., Hu, D., Wang, X., Xiao, Z., Sui, Y., Zhu, C., & Wang, J. (2016). Adjuvant Treatment with Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: A Meta-analysis of Randomized Controlled Trials. Phytotherapy Research : PTR, 30(7), 1095-103. https://doi.org/10.1002/ptr.5628
Song T, et al. Adjuvant Treatment With Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: a Meta-analysis of Randomized Controlled Trials. Phytother Res. 2016;30(7):1095-103. PubMed PMID: 27145435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adjuvant Treatment with Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: A Meta-analysis of Randomized Controlled Trials. AU - Song,Tao, AU - Hou,Xiaoli, AU - Yu,Xiaohui, AU - Wang,Zhen, AU - Wang,Ruiren, AU - Li,Yanling, AU - Hu,Dan, AU - Wang,Xiaohong, AU - Xiao,Zhengzheng, AU - Sui,Yong, AU - Zhu,Chunhong, AU - Wang,Jing, Y1 - 2016/05/04/ PY - 2015/11/02/received PY - 2016/03/17/revised PY - 2016/03/28/accepted PY - 2016/5/5/entrez PY - 2016/5/5/pubmed PY - 2017/4/18/medline KW - Yupingfeng KW - children KW - immunomodulating function KW - meta-analysis KW - recurrent respiratory tract infections SP - 1095 EP - 103 JF - Phytotherapy research : PTR JO - Phytother Res VL - 30 IS - 7 N2 - This meta-analysis aimed to evaluate the immunomodulating function of Yupingfeng Formula (YPFF) in children with recurrent respiratory tract infections (RRTIs). The PubMed, EMBASE, Cochrane Library, CNKI and WanFang databases were searched for randomized controlled trials comparing with and without YPFF for RRTIs in children. Twelve trials with 1236 patients were identified. Adjuvant treatment with YPFF significantly increased serum levels of IgA (weighted mean difference [WMD] 0.33 mg/mL; 95% confidence interval [CI] 0.20 to 0.45), IgG (WMD 1.36 mg/mL; 95% CI 1.06 to 1.65), IgM (WMD 0.16 mg/mL; 95% CI 0.02 to 0.31), and CD3(+) T-lymphocytes (WMD 10.16%; 95% CI 4.62 to 15.69) but not CD4(+) T-lymphocytes (WMD 3.16%; 95% CI -0.27 to 6.59) and CD8(+) T-lymphocytes (WMD -0.84%; 95% CI -2.50 to 0.81). YPFF also reduced the frequency of RRTIs (WMD -3.80 times; 95% CI -4.86 to -2.74) and increased total effective rates of symptom improvement (risk ratio: 1.44; 95% CI 1.19 to 1.75). Adjuvant treatment with YPFF could improve total clinical effective rate and decrease the frequency of respiratory tract infections in children with RRTIs. The beneficial effects of YPFF may be correlated to its immunomodulating action. More well-designed trials with larger sample sizes are needed to evaluate its efficacy and safety. Copyright © 2016 John Wiley & Sons, Ltd. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/27145435/Adjuvant_Treatment_with_Yupingfeng_Formula_for_Recurrent_Respiratory_Tract_Infections_in_Children:_A_Meta_analysis_of_Randomized_Controlled_Trials_ L2 - https://doi.org/10.1002/ptr.5628 DB - PRIME DP - Unbound Medicine ER -