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Phosphoroorganic Metal Complexes in Therapeutics.
Mini Rev Med Chem. 2016; 16(17):1359-1373.MR

Abstract

The present mini-review highlights recent developments on antitumor activity of metal-based therapeutics which have been a subject of researches for the last few decades. In 1965, Rosenberg found that during an electrolysis on platinum electrodes a complex of Pt is generated which inhibited to a great extent a binary fission in Escherichia coli bacteria. This discovery started a new chapter in medicinal chemistry and the interesting properties of cisplatin were soon applied in cancer therapy especially in curing genitourinary tumors. However, various side effects limited its use in medical treatment. Since then a great number of other metal-organic complexes based on platinum, palladium, ruthenium, gold, copper, silver, rhodium, osmium, rhenium, iridium and others have been synthesized. Among them, NAMI-A and KP1019 have recently undergone clinical trials. In this review paper we report a detailed account of metal complexes with phosphorus-based ligands which are of particular interest in therapeutics.

Authors+Show Affiliations

Dept. Organic Chemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland. sebdemko@pg.gda.pl.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27145849

Citation

Demkowicz, Sebastian, et al. "Phosphoroorganic Metal Complexes in Therapeutics." Mini Reviews in Medicinal Chemistry, vol. 16, no. 17, 2016, pp. 1359-1373.
Demkowicz S, Kozak W, Daśko M, et al. Phosphoroorganic Metal Complexes in Therapeutics. Mini Rev Med Chem. 2016;16(17):1359-1373.
Demkowicz, S., Kozak, W., Daśko, M., & Rachon, J. (2016). Phosphoroorganic Metal Complexes in Therapeutics. Mini Reviews in Medicinal Chemistry, 16(17), 1359-1373.
Demkowicz S, et al. Phosphoroorganic Metal Complexes in Therapeutics. Mini Rev Med Chem. 2016;16(17):1359-1373. PubMed PMID: 27145849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphoroorganic Metal Complexes in Therapeutics. AU - Demkowicz,Sebastian, AU - Kozak,Witold, AU - Daśko,Mateusz, AU - Rachon,Janusz, PY - 2015/10/30/received PY - 2016/03/07/revised PY - 2016/06/19/accepted PY - 2016/5/6/pubmed PY - 2017/3/3/medline PY - 2016/5/6/entrez SP - 1359 EP - 1373 JF - Mini reviews in medicinal chemistry JO - Mini Rev Med Chem VL - 16 IS - 17 N2 - The present mini-review highlights recent developments on antitumor activity of metal-based therapeutics which have been a subject of researches for the last few decades. In 1965, Rosenberg found that during an electrolysis on platinum electrodes a complex of Pt is generated which inhibited to a great extent a binary fission in Escherichia coli bacteria. This discovery started a new chapter in medicinal chemistry and the interesting properties of cisplatin were soon applied in cancer therapy especially in curing genitourinary tumors. However, various side effects limited its use in medical treatment. Since then a great number of other metal-organic complexes based on platinum, palladium, ruthenium, gold, copper, silver, rhodium, osmium, rhenium, iridium and others have been synthesized. Among them, NAMI-A and KP1019 have recently undergone clinical trials. In this review paper we report a detailed account of metal complexes with phosphorus-based ligands which are of particular interest in therapeutics. SN - 1875-5607 UR - https://www.unboundmedicine.com/medline/citation/27145849/Phosphoroorganic_Metal_Complexes_in_Therapeutics_ L2 - http://www.eurekaselect.com/141802/article DB - PRIME DP - Unbound Medicine ER -